166
J. Pospíšil et al.
192. Lee J, Kim JH (2016) Kaempferol inhibits pancreatic cancer cell growth and migration through
the blockade of EGFR-related pathway in vitro. PLoS One 11:e0155264
193. Song W, Dang Q, Xu D, Chen Y, Zhu G, Wu K, Zeng J, Long Q, Wang X, He D, Li L (2014)
Kaempferol induces cell cycle arrest and apoptosis in renal cell carcinoma through EGFR/p38
signaling. Oncol Rep 31:1350
194. Zhang Y, Chen AY, Li M, Chen C, Yao Q (2008) Ginkgo biloba extract kaempferol inhibits
cell proliferation and induces apoptosis in pancreatic cancer cells. J Surg Res 148:17
195. Xu H, Lv M, Tian X (2009) A review on hemisynthesis, biosynthesis, biological activities,
mode of action, and structure-activity relationship of podophyllotoxins: 2003–2007. Curr
Med Chem 16:327
196. von Krogh G, Longstaff E (2001) Podophyllin office therapy against condyloma should be
abandoned. Sex Transm Infect 77:409
197. Zálešák F, Bon DJYD, Pospíšil J (2019) Lignans and neolignans: plant secondary metabolites
as a reservoir of biologically active substances. Pharmacol Res 146:104284
198. Ardalani H, Avan A, Ghayour-Mobarhan M (2017) Podophyllotoxin: a novel potential natural
anticancer agent. Avicenna J Phytomed 7:285
199. Gordaliza M, García PA, del Corral JMM, Castro MA, Gómez-Zurita MA (2004) Podophyllotoxin: distribution, sources, applications, and new cytotoxic derivatives. Toxicon 44:441
200. Gordaliza M, Castro MA, del Corral JM, Feliciano AS (2000) Antitumor properties of
podophyllotoxin and related compounds. Curr Pharm Des 6:1811
201. Hande KR (1998) Etoposide: four decades of development of a topoisomerase II inhibitor.
Eur J Cancer 34:1514
202. Fukamiya N, Lee K-H (1986) Antitumor agents, 81. Justicidin-A and diphyllin, two cytotoxic
principles from Justicia procumbens. J Nat Prod 49:348
203. Tian J, Hao X, He H (2006) A new lignan and four new lignan glycosides from Mananthes
patentiflora. Helv Chim Acta 89:291
204. Ferrero-Miliani L, Nielsen OH, Andersen PS, Girardin SE (2007) Chronic inflammation:
importance of NOD2 and NALP3 in interleukin-1beta generation. Clin Exp Immunol 147:227
205. Yahfoufi N, Alsadi N, Jambi M, Matar C (2018) The immunomodulatory and antiinflammatory
role of polyphenols. Nutrients 10:1618
206. Hayashi K, Narutaki K, Nagaoka Y, Hayashi T, Uesato S (2010) Therapeutic effect of arctiin
and arctigenin in immunocompetent and immuno-compromised mice infected with influenza
A virus. Biol Pharm Bull 33:1199
207. Awale S, Lu J, Kalauni SK, Kurashima Y, Tezuka Y, Kadota S, Esumi H (2006) Identification
of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells
to nutrient starvation. Cancer Res 66:1751
208. Kim J-Y, Hwang J-H, Cha M-R, Yoon M-Y, Son E-S, Tomida A, Ko B, Song S-W, Shin-ya
K, Hwang Y, Park H-R (2010) Arctigenin blocks the unfolded protein response and shows
therapeutic antitumor activity. J Cell Physiol 224:33
209. Lee S, Shin S, Kim H, Han S, Kim K, Kwon J, Kwak J-H, Lee C-K, Ha N-J, Yim D, Kim
K (2011) Antiinflammatory function of arctiin by inhibiting COX-2 expression via NF-κB
pathways. J Inflamm 8:16
210. Xie L-H, Ahn E-M, Akao T, Abdel-Hafez AA-M, Nakamura N, Hattori M (2003) Transformation of arctiin to estrogenic and antiestrogenic substances by human intestinal bacteria.
Chem Pharm Bull 51:378
211. Feng T, Cao W, Shen W, Zhang L, Gu X, Gui Y, Tsai H-I, Liu X, Li J, Zhang J, Li S, Wu F, Liu
Y (2017) Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative
breast cancer therapy. Oncotarget 8:329
212. Lee J, Imm J-Y, Lee S-H (2017) β-Catenin mediates antiadipogenic and anticancer effects of
arctigenin in preadipocytes and breast cancer cells. J Agric Food Chem 65:2513
213. Zhang M, Cai S, Zuo B, Gong W, Tang Z, Zhou D, Weng M, Qin Y, Wang S, Liu J, Ma F, Quan
Z (2017) Arctigenin induced gallbladder cancer senescence through modulating epidermal
growth factor receptor pathway. Tumour Biol 39:329
J. Pospíšil et al.
192. Lee J, Kim JH (2016) Kaempferol inhibits pancreatic cancer cell growth and migration through
the blockade of EGFR-related pathway in vitro. PLoS One 11:e0155264
193. Song W, Dang Q, Xu D, Chen Y, Zhu G, Wu K, Zeng J, Long Q, Wang X, He D, Li L (2014)
Kaempferol induces cell cycle arrest and apoptosis in renal cell carcinoma through EGFR/p38
signaling. Oncol Rep 31:1350
194. Zhang Y, Chen AY, Li M, Chen C, Yao Q (2008) Ginkgo biloba extract kaempferol inhibits
cell proliferation and induces apoptosis in pancreatic cancer cells. J Surg Res 148:17
195. Xu H, Lv M, Tian X (2009) A review on hemisynthesis, biosynthesis, biological activities,
mode of action, and structure-activity relationship of podophyllotoxins: 2003–2007. Curr
Med Chem 16:327
196. von Krogh G, Longstaff E (2001) Podophyllin office therapy against condyloma should be
abandoned. Sex Transm Infect 77:409
197. Zálešák F, Bon DJYD, Pospíšil J (2019) Lignans and neolignans: plant secondary metabolites
as a reservoir of biologically active substances. Pharmacol Res 146:104284
198. Ardalani H, Avan A, Ghayour-Mobarhan M (2017) Podophyllotoxin: a novel potential natural
anticancer agent. Avicenna J Phytomed 7:285
199. Gordaliza M, García PA, del Corral JMM, Castro MA, Gómez-Zurita MA (2004) Podophyllotoxin: distribution, sources, applications, and new cytotoxic derivatives. Toxicon 44:441
200. Gordaliza M, Castro MA, del Corral JM, Feliciano AS (2000) Antitumor properties of
podophyllotoxin and related compounds. Curr Pharm Des 6:1811
201. Hande KR (1998) Etoposide: four decades of development of a topoisomerase II inhibitor.
Eur J Cancer 34:1514
202. Fukamiya N, Lee K-H (1986) Antitumor agents, 81. Justicidin-A and diphyllin, two cytotoxic
principles from Justicia procumbens. J Nat Prod 49:348
203. Tian J, Hao X, He H (2006) A new lignan and four new lignan glycosides from Mananthes
patentiflora. Helv Chim Acta 89:291
204. Ferrero-Miliani L, Nielsen OH, Andersen PS, Girardin SE (2007) Chronic inflammation:
importance of NOD2 and NALP3 in interleukin-1beta generation. Clin Exp Immunol 147:227
205. Yahfoufi N, Alsadi N, Jambi M, Matar C (2018) The immunomodulatory and antiinflammatory
role of polyphenols. Nutrients 10:1618
206. Hayashi K, Narutaki K, Nagaoka Y, Hayashi T, Uesato S (2010) Therapeutic effect of arctiin
and arctigenin in immunocompetent and immuno-compromised mice infected with influenza
A virus. Biol Pharm Bull 33:1199
207. Awale S, Lu J, Kalauni SK, Kurashima Y, Tezuka Y, Kadota S, Esumi H (2006) Identification
of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells
to nutrient starvation. Cancer Res 66:1751
208. Kim J-Y, Hwang J-H, Cha M-R, Yoon M-Y, Son E-S, Tomida A, Ko B, Song S-W, Shin-ya
K, Hwang Y, Park H-R (2010) Arctigenin blocks the unfolded protein response and shows
therapeutic antitumor activity. J Cell Physiol 224:33
209. Lee S, Shin S, Kim H, Han S, Kim K, Kwon J, Kwak J-H, Lee C-K, Ha N-J, Yim D, Kim
K (2011) Antiinflammatory function of arctiin by inhibiting COX-2 expression via NF-κB
pathways. J Inflamm 8:16
210. Xie L-H, Ahn E-M, Akao T, Abdel-Hafez AA-M, Nakamura N, Hattori M (2003) Transformation of arctiin to estrogenic and antiestrogenic substances by human intestinal bacteria.
Chem Pharm Bull 51:378
211. Feng T, Cao W, Shen W, Zhang L, Gu X, Gui Y, Tsai H-I, Liu X, Li J, Zhang J, Li S, Wu F, Liu
Y (2017) Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative
breast cancer therapy. Oncotarget 8:329
212. Lee J, Imm J-Y, Lee S-H (2017) β-Catenin mediates antiadipogenic and anticancer effects of
arctigenin in preadipocytes and breast cancer cells. J Agric Food Chem 65:2513
213. Zhang M, Cai S, Zuo B, Gong W, Tang Z, Zhou D, Weng M, Qin Y, Wang S, Liu J, Ma F, Quan
Z (2017) Arctigenin induced gallbladder cancer senescence through modulating epidermal
growth factor receptor pathway. Tumour Biol 39:329