Antileishmanial Activity of Lignans, Neolignans …
125
CO2H
H2N
25 (L-phenylalanine)
12 ((2S,3S)-erythro-4-phosphate)
13 (phosphoenol pyruvate)
O
OH
OH
H2O3PO
O
O
H2C
OPO3H2
3-deoxy-D-arabino-heptulosonate-7-phosphate synthase
H2O3PO
OH
OH
O
CO2H
3-dehydroquinate
synthase
shikimate pathway
HO
OH
CO2H
HO
O
15 ((1R,3R,4S)-3-dehydroquinic acid)
OH
OH
O
16 ((4S,5R)-3-dehydroshikimic acid)
shikimate-5-dehydrogenase
OH
OH
OH
HO2C
shikimate kinase
17 ((3R,4S,5R)-shikimic acid)
OH
OH
OPO3H2
HO2C
HO
O
H2O3PO
CO2H
CO2H
18 ((3R,4S,5R)-shikimate-3-phosphate)
HO2C
3-dehydroquinate
dehydratase
19 ((3R,4S,5R)-5-enolpyruvyl
shikimate-3-phosphate)
HO
O
CO2H
CO2H
20 ((3R,4R)-chorismate)
CO2H
H2N
HO
24 (L-tyrosine)
N
H
NH2
CO2H
21 (L-tryptophan)
plastid
OH
CO2H
CO2H
O
22 ((1S,4S)-prephenate)
chorismate mutase
OH
CO2H
CO2H
23 ((1S,4R)-1-(S)-arogenate)
NH2
prephenate amniotransferase
arogenate dehydratase
OH
14 ((4R,5S,6R)-3-deoxy-arabinoheptulosonate-7-phosphate)
Fig. 3
Shikimate pathway – from chorismic acid to aromatic amino acids and phenylpropanoids [88–90]