110
S. B. Christensen et al.
188. Møller JV, Nissen P, Sorensen TLM, le Maire M (2005) Transport mechanism of the
sarcoplasmic reticulum Ca 2+ -ATPase pump. Curr Opin Struct Biol 15:387
189. Møller JV, Olesen C, Winther AML, Nissen P (2010) The sarcoplasmic Ca 2+ -ATPase: design
of a perfect chemi-osmotic pump. Q Rev Biophys 43:501
190. Sørensen TL, Møller JV, Nissen P (2004) Phosphoryl transfer and calcium ion occlusion in
the calcium pump. Science 304:1672
191. Mahaney JE, Albers RW, Waggoner JR, Kutchai HC, Froehlich JP (2005) Intermolecular
conformational coupling and free energy exchange enhance the catalytic efficiency of cardiac
muscle SERCA2a following the relief of phospholamban inhibition. Biochemistry 44:7713
192. Young HS, Stokes DL (2004) The mechanics of calcium transport. J Membr Biol 198:55
193. Rubal JJ, Moreno-Dorado FJ, Guerra FM, Jorge ZD, Galán M, Salido GM, Christensen SB,
Søhoel H, Massanet GM (2010) A phenylpropanoid, a slovenolide, two sulphur-containing
germacranes and Ca 2+ -ATPase inhibitors from Thapsia villosa. Planta Med 76:284
194. De Ford C, Calderón C, Sehgal P, Fedosova NU, Murillo R, Olesen C, Nissen P, Møller JV,
Merfort I (2015) Discovery of tricyclic clerodane diterpenes as sarco/endoplasmic reticulum
Ca 2+ -ATPase inhibitors and structure-activity relationships. J Nat Prod 78:1262
195. Pimentel AA, Felibertt P, Sojo F, Colman L, Mayora A, Silva ML, Rojas H, Dipolo R, Suarez
AI, Compagnone RS, Arvelo F, Galindo-Castro I, Sanctis JB, Chirino P, Benaim G (2012) The
marine sponge toxin agelasine B increases the intracellular Ca 2+ concentration and induces
apoptosis in human breast cancer cells (MCF-7). Cancer Chemother Pharmacol 69:71
196. Sørensen TL, Olesen C, Jensen AML, Møller JV, Nissen P (2006) Crystals of sarcoplasmic
reticulum Ca 2+ -ATPase. J Biotechnol 124:704
197. Noel F, Cunha VMN, Silva CLM, Mendonca-Silva DL (2001) Control of calcium homeostasis
in Schistosoma mansoni. Mem Inst Oswaldo Cruz 96(Suppl):85
198. David-Bosne S, Clausen MV, Poulsen H, Moeller JV, Nissen P, Le Maire M (2016) Reappraising the effects of artemisinin on the ATPase activity of PfATP6 and SERCA1a E255L
expressed in Xenopus laevis oocytes. Nat Struct Mol Biol 23:1
199. Silva Z, Verissimo T, Videira PA, Novo C (2015) Protein disulfide isomerases: impact of
thapsigargin treatment on their expression in melanoma cell lines. Int J Biol Macromol 79:44
200. Cheny LH, Jiangy CC, Kiejda KA, Wang YF, Thorne RF, Zhang XD, Hersey P (2007) Thapsigargin sensitizes human melanoma cells to TRAIL-induced apoptosis by up-regulation of
TRAIL-R2 through the unfolded protein response. Carcinogenesis 28:2328
201. Muramatsu Y, Maemoto T, Iwashita A, Matsuoka N (2007) Novel neuroprotective compound
SCH-20148 rescues thymocytes and SH-SY5Y cells from thapsigargin-induced mitochondrial
membrane potential reduction and cell death. Eur J Pharmacol 563:40
202. Karunakaran U, Lee JE, Elumalai S, Moon JS, Won KC (2019) Myricetin prevents
thapsigargin-induced CDK5-P66Shc signalosome mediated pancreatic β-cell dysfunction.
Free Radic Biol Med 141:59
203. Janyou A, Changtam C, Suksamrarn A, Tocharus C, Tocharus J (2015) Suppression effects of
O-demethyldemethoxycurcumin on thapsigargin triggered on endoplasmic reticulum stress
in SK-N-SH cells. NeuroToxicology 50:92
204. Furuya Y, Isaacs JT (1994) Proliferation-dependent vs. independent programmed cell death
of prostatic cancer cells involves distinct gene regulation. Prostate 25:301
205. Skala W, Utzschneider DT, Magdolen V, Debel M, Guo S, Craik CS, Brandstetter H, Goettig
P (2014) Structure-function analyses of human kallikrein-related peptidase 2 establish the
99-loop as master regulator of activity. J Biol Chem 289:34267
206. Hassan MI, Kumar V, Singh TP, Yadav S (2007) Structural model of human PSA: a target for
prostate cancer therapy. Chem Biol Drug Des 70:261
207. Dannoon S, Ganguly T, Cahaya H, Geruntho JJ, Galliher MS, Beyer SK, Choy CJ, Hopkins
MR, Regan M, Blecha JE, Skultetyova L, Drake CR, Jivan S, Barinka C, Jones EF, Berkman
CE, VanBroklin HF (2016) Structure-activity relationship of 18 F-labeled phosphoramidate
peptidomimetic prostate-specific membrane antigen (PSMA)-targeted inhibitor analogues for
PET imaging of prostate cancer. J Med Chem 59:5684
S. B. Christensen et al.
188. Møller JV, Nissen P, Sorensen TLM, le Maire M (2005) Transport mechanism of the
sarcoplasmic reticulum Ca 2+ -ATPase pump. Curr Opin Struct Biol 15:387
189. Møller JV, Olesen C, Winther AML, Nissen P (2010) The sarcoplasmic Ca 2+ -ATPase: design
of a perfect chemi-osmotic pump. Q Rev Biophys 43:501
190. Sørensen TL, Møller JV, Nissen P (2004) Phosphoryl transfer and calcium ion occlusion in
the calcium pump. Science 304:1672
191. Mahaney JE, Albers RW, Waggoner JR, Kutchai HC, Froehlich JP (2005) Intermolecular
conformational coupling and free energy exchange enhance the catalytic efficiency of cardiac
muscle SERCA2a following the relief of phospholamban inhibition. Biochemistry 44:7713
192. Young HS, Stokes DL (2004) The mechanics of calcium transport. J Membr Biol 198:55
193. Rubal JJ, Moreno-Dorado FJ, Guerra FM, Jorge ZD, Galán M, Salido GM, Christensen SB,
Søhoel H, Massanet GM (2010) A phenylpropanoid, a slovenolide, two sulphur-containing
germacranes and Ca 2+ -ATPase inhibitors from Thapsia villosa. Planta Med 76:284
194. De Ford C, Calderón C, Sehgal P, Fedosova NU, Murillo R, Olesen C, Nissen P, Møller JV,
Merfort I (2015) Discovery of tricyclic clerodane diterpenes as sarco/endoplasmic reticulum
Ca 2+ -ATPase inhibitors and structure-activity relationships. J Nat Prod 78:1262
195. Pimentel AA, Felibertt P, Sojo F, Colman L, Mayora A, Silva ML, Rojas H, Dipolo R, Suarez
AI, Compagnone RS, Arvelo F, Galindo-Castro I, Sanctis JB, Chirino P, Benaim G (2012) The
marine sponge toxin agelasine B increases the intracellular Ca 2+ concentration and induces
apoptosis in human breast cancer cells (MCF-7). Cancer Chemother Pharmacol 69:71
196. Sørensen TL, Olesen C, Jensen AML, Møller JV, Nissen P (2006) Crystals of sarcoplasmic
reticulum Ca 2+ -ATPase. J Biotechnol 124:704
197. Noel F, Cunha VMN, Silva CLM, Mendonca-Silva DL (2001) Control of calcium homeostasis
in Schistosoma mansoni. Mem Inst Oswaldo Cruz 96(Suppl):85
198. David-Bosne S, Clausen MV, Poulsen H, Moeller JV, Nissen P, Le Maire M (2016) Reappraising the effects of artemisinin on the ATPase activity of PfATP6 and SERCA1a E255L
expressed in Xenopus laevis oocytes. Nat Struct Mol Biol 23:1
199. Silva Z, Verissimo T, Videira PA, Novo C (2015) Protein disulfide isomerases: impact of
thapsigargin treatment on their expression in melanoma cell lines. Int J Biol Macromol 79:44
200. Cheny LH, Jiangy CC, Kiejda KA, Wang YF, Thorne RF, Zhang XD, Hersey P (2007) Thapsigargin sensitizes human melanoma cells to TRAIL-induced apoptosis by up-regulation of
TRAIL-R2 through the unfolded protein response. Carcinogenesis 28:2328
201. Muramatsu Y, Maemoto T, Iwashita A, Matsuoka N (2007) Novel neuroprotective compound
SCH-20148 rescues thymocytes and SH-SY5Y cells from thapsigargin-induced mitochondrial
membrane potential reduction and cell death. Eur J Pharmacol 563:40
202. Karunakaran U, Lee JE, Elumalai S, Moon JS, Won KC (2019) Myricetin prevents
thapsigargin-induced CDK5-P66Shc signalosome mediated pancreatic β-cell dysfunction.
Free Radic Biol Med 141:59
203. Janyou A, Changtam C, Suksamrarn A, Tocharus C, Tocharus J (2015) Suppression effects of
O-demethyldemethoxycurcumin on thapsigargin triggered on endoplasmic reticulum stress
in SK-N-SH cells. NeuroToxicology 50:92
204. Furuya Y, Isaacs JT (1994) Proliferation-dependent vs. independent programmed cell death
of prostatic cancer cells involves distinct gene regulation. Prostate 25:301
205. Skala W, Utzschneider DT, Magdolen V, Debel M, Guo S, Craik CS, Brandstetter H, Goettig
P (2014) Structure-function analyses of human kallikrein-related peptidase 2 establish the
99-loop as master regulator of activity. J Biol Chem 289:34267
206. Hassan MI, Kumar V, Singh TP, Yadav S (2007) Structural model of human PSA: a target for
prostate cancer therapy. Chem Biol Drug Des 70:261
207. Dannoon S, Ganguly T, Cahaya H, Geruntho JJ, Galliher MS, Beyer SK, Choy CJ, Hopkins
MR, Regan M, Blecha JE, Skultetyova L, Drake CR, Jivan S, Barinka C, Jones EF, Berkman
CE, VanBroklin HF (2016) Structure-activity relationship of 18 F-labeled phosphoramidate
peptidomimetic prostate-specific membrane antigen (PSMA)-targeted inhibitor analogues for
PET imaging of prostate cancer. J Med Chem 59:5684