176
Y. Kuziv et al.
cell near the laser beam transmission region [15]. Thus, the absorption of laser light
λ irr = 650 nm occurs in Au nanoparticles. Since the fluorescence in the analyzed
samples is not observed and there are no reasons for photochemical transformations,
it can be assumed that the scattering of all absorbed light energy happens by excitation
of oscillations. Namely, all absorbed light energy is transformed into thermal energy.
Thus, the advantage of a ternary nanosystem D-g-PAA/AuNPs/Ce6 for photodynamic therapy based on two factors: production of singlet oxygen by photosensitizer and local heating (hypertermia) of solution near AuNPs under laser irradiation. This conclusion explains the successful examination of D-g-PAA/AuNPs/Ce6
nanocomposite for photodynamic treatment of tumor cells [10].
Acknowledgements This publication is supported in part by the Ministry of the Education
and Science of Ukraine: joint Ukrainian-Belarusian research and development projects “Design
and physico-chemical properties of novel multicomponent nanosystems for the treatment and
diagnostics of solid tumors” (2019–2020).
References
1. Doughty ACV, Hoover AR, Layton E et al (2019) Nanomaterial applications in photothermal
therapy for cancer. Materials (Basel) 12(5):779. https://doi.org/10.3390/ma12050779
2. Liu P, Yang W, Shi L, Zhang H et al (2019) Concurrent photothermal therapy and photodynamic
therapy for cutaneous squamous cell carcinoma by gold nanoclusters under a single NIR laser
irradiation. J Mater Chem B 7:6924–6933
3. Yang Z, Sun Z, Ren Y et al (2019) Advances in nanomaterials for use in photothermal and
photodynamic therapeutics (Review). Molecu Med Reports 20(1):5–15. https://doi.org/10.
3892/mmr.2019.10218
4. Riley RS, O’Sullivan RK et al (2018) Evaluating Nanoshells and a potent Biladiene photosensitizer for dual photothermal and photodynamic therapy of triple negative breast cancer cells.
Nanomaterials
5. Oh J, Yoon H-J, Park J-H (2013) Nanoparticle platforms for combined photothermal and
photodynamic therapy. Biomed Eng Lett 3:67–73
6. Vines JB, Yoon JH, Ryu NE et al (2019) Gold nanoparticles for photothermal cancer therapy.
Front Chem 5(7):167. https://doi.org/10.3389/fchem.2019.00167
7. Kennedy LC, Bickford LR, Lewinski NA et al (2011) A new era for cancer treatment: goldnanoparticle-mediated thermal therapies. Small 7:169–183. https://doi.org/10.1002/smll.201
000134
8. Juzeniene A (2009) Chlorin e6-based photosensitizers for photodynamic therapy and photodiagnosis. Photodiagnosis Photodyn Therapy 6(2):94–96. https://doi.org/10.1016/j.pdpdt.2009.
06.001
9. Liang H, Zhou Z, Luo R et al (2018) Tumor-specific activated photodynamic therapy with an
oxidation-regulated strategy for enhancing anti-tumor efficacy. Theranostics 8(18):5059–5071.
https://doi.org/10.7150/thno.28344
10. Kutsevol N, Naumenko A, Harahuts Yu et al (2018) New hybrid composites for photodynamic
therapy: synthesis, characterization and biological study. Appl Nanosci 2018:1–8. https://doi.
org/10.1007/s13204-018-0768-y
Y. Kuziv et al.
cell near the laser beam transmission region [15]. Thus, the absorption of laser light
λ irr = 650 nm occurs in Au nanoparticles. Since the fluorescence in the analyzed
samples is not observed and there are no reasons for photochemical transformations,
it can be assumed that the scattering of all absorbed light energy happens by excitation
of oscillations. Namely, all absorbed light energy is transformed into thermal energy.
Thus, the advantage of a ternary nanosystem D-g-PAA/AuNPs/Ce6 for photodynamic therapy based on two factors: production of singlet oxygen by photosensitizer and local heating (hypertermia) of solution near AuNPs under laser irradiation. This conclusion explains the successful examination of D-g-PAA/AuNPs/Ce6
nanocomposite for photodynamic treatment of tumor cells [10].
Acknowledgements This publication is supported in part by the Ministry of the Education
and Science of Ukraine: joint Ukrainian-Belarusian research and development projects “Design
and physico-chemical properties of novel multicomponent nanosystems for the treatment and
diagnostics of solid tumors” (2019–2020).
References
1. Doughty ACV, Hoover AR, Layton E et al (2019) Nanomaterial applications in photothermal
therapy for cancer. Materials (Basel) 12(5):779. https://doi.org/10.3390/ma12050779
2. Liu P, Yang W, Shi L, Zhang H et al (2019) Concurrent photothermal therapy and photodynamic
therapy for cutaneous squamous cell carcinoma by gold nanoclusters under a single NIR laser
irradiation. J Mater Chem B 7:6924–6933
3. Yang Z, Sun Z, Ren Y et al (2019) Advances in nanomaterials for use in photothermal and
photodynamic therapeutics (Review). Molecu Med Reports 20(1):5–15. https://doi.org/10.
3892/mmr.2019.10218
4. Riley RS, O’Sullivan RK et al (2018) Evaluating Nanoshells and a potent Biladiene photosensitizer for dual photothermal and photodynamic therapy of triple negative breast cancer cells.
Nanomaterials
5. Oh J, Yoon H-J, Park J-H (2013) Nanoparticle platforms for combined photothermal and
photodynamic therapy. Biomed Eng Lett 3:67–73
6. Vines JB, Yoon JH, Ryu NE et al (2019) Gold nanoparticles for photothermal cancer therapy.
Front Chem 5(7):167. https://doi.org/10.3389/fchem.2019.00167
7. Kennedy LC, Bickford LR, Lewinski NA et al (2011) A new era for cancer treatment: goldnanoparticle-mediated thermal therapies. Small 7:169–183. https://doi.org/10.1002/smll.201
000134
8. Juzeniene A (2009) Chlorin e6-based photosensitizers for photodynamic therapy and photodiagnosis. Photodiagnosis Photodyn Therapy 6(2):94–96. https://doi.org/10.1016/j.pdpdt.2009.
06.001
9. Liang H, Zhou Z, Luo R et al (2018) Tumor-specific activated photodynamic therapy with an
oxidation-regulated strategy for enhancing anti-tumor efficacy. Theranostics 8(18):5059–5071.
https://doi.org/10.7150/thno.28344
10. Kutsevol N, Naumenko A, Harahuts Yu et al (2018) New hybrid composites for photodynamic
therapy: synthesis, characterization and biological study. Appl Nanosci 2018:1–8. https://doi.
org/10.1007/s13204-018-0768-y