24
1 Introduction
119. Okamoto T, Zobel K, Fedorova A, Quan C, Yang H, Fairbrother WJ, Huang DCS, Smith BJ,
Deshayes K, Czabotar PE (2013) Stabilizing the pro-apoptotic BimBH3 Helix (BimSAHB)
does Not necessarily enhance affinity or biological activity. ACS Chem Biol 8:297–302
120. Wei SJ, Joseph T, Chee S, Li L, Yurlova L, Zolghadr K, Brown C, Lane D, Verma C, Ghadessy
F (2013) Inhibition of nutlin-resistant HDM2 mutants by stapled peptides, PLoS One 8
121. Frank AO, Vangamudi B, Feldkamp MD, Souza-Fagundes EM, Luzwick JW, Cortez D,
Olejniczak ET, Waterson AG, Rossanese OW, Chazin WJ, Fesik SW (2014) Discovery of
a potent stapled helix peptide that binds to the 70 N domain of replication protein A. J Med
Chem 57:2455–2461
122. Spiegel J, Cromm PM, Itzen A, Goody RS, Grossmann TN, Waldmann H (2014) Direct
targeting of rab-Gtpase-effector interactions**. Angew Chem Int Edit 53:2498–2503
123. Wang YX, Ho TG, Bertinetti D, Neddermann M, Franz E, Mo GCH, Schendowich LP, Sukhu
A, Spelts RC, Zhang J, Herberg FW, Kennedy EJ (2014) Isoform-selective disruption of
AKAP-localized PKA using hydrocarbon stapled peptides. ACS Chem Biol 9:635–642
124. Leshchiner ES, Parkhitko A, Bird GH, Luccarelli J, Bellairs JA, Escudero S, Opoku-Nsiah
K, Godes M, Perrimon N, Walensky LD (2015) Direct inhibition of oncogenic KRAS by
hydrocarbon-stapled SOS1 helices. Proc Natl Acad Sci U S A 112:1761–1766
125. Wang YX, Ho THG, Franz E, Hermann JS, Smith FD, Hehnly H, Esseltine JL, Hanold LE,
Murph MM, Bertinetti D, Scott JD, Herberg FW, Kennedy EJ (2015) PKA-type I selective
constrained peptide disruptors of AKAP complexes. ACS Chem Biol 10:1502–1510
126. Araghi RR, Ryan JA, Letai A, Keating AE (2016) Rapid optimization of Mcl-1 inhibitors using
stapled peptide libraries including non-natural side chains. ACS Chem Biol 11:1238–1244
127. Teng Y, Bahassan A, Dong DY, Hanold LE, Ren XO, Kennedy EJ, Cowell JK (2016) Targeting
the WASF3-CYFIP1 complex Using stapled peptides suppresses Cancer cell invasion. Cancer
Res 76:965–973
1 Introduction
119. Okamoto T, Zobel K, Fedorova A, Quan C, Yang H, Fairbrother WJ, Huang DCS, Smith BJ,
Deshayes K, Czabotar PE (2013) Stabilizing the pro-apoptotic BimBH3 Helix (BimSAHB)
does Not necessarily enhance affinity or biological activity. ACS Chem Biol 8:297–302
120. Wei SJ, Joseph T, Chee S, Li L, Yurlova L, Zolghadr K, Brown C, Lane D, Verma C, Ghadessy
F (2013) Inhibition of nutlin-resistant HDM2 mutants by stapled peptides, PLoS One 8
121. Frank AO, Vangamudi B, Feldkamp MD, Souza-Fagundes EM, Luzwick JW, Cortez D,
Olejniczak ET, Waterson AG, Rossanese OW, Chazin WJ, Fesik SW (2014) Discovery of
a potent stapled helix peptide that binds to the 70 N domain of replication protein A. J Med
Chem 57:2455–2461
122. Spiegel J, Cromm PM, Itzen A, Goody RS, Grossmann TN, Waldmann H (2014) Direct
targeting of rab-Gtpase-effector interactions**. Angew Chem Int Edit 53:2498–2503
123. Wang YX, Ho TG, Bertinetti D, Neddermann M, Franz E, Mo GCH, Schendowich LP, Sukhu
A, Spelts RC, Zhang J, Herberg FW, Kennedy EJ (2014) Isoform-selective disruption of
AKAP-localized PKA using hydrocarbon stapled peptides. ACS Chem Biol 9:635–642
124. Leshchiner ES, Parkhitko A, Bird GH, Luccarelli J, Bellairs JA, Escudero S, Opoku-Nsiah
K, Godes M, Perrimon N, Walensky LD (2015) Direct inhibition of oncogenic KRAS by
hydrocarbon-stapled SOS1 helices. Proc Natl Acad Sci U S A 112:1761–1766
125. Wang YX, Ho THG, Franz E, Hermann JS, Smith FD, Hehnly H, Esseltine JL, Hanold LE,
Murph MM, Bertinetti D, Scott JD, Herberg FW, Kennedy EJ (2015) PKA-type I selective
constrained peptide disruptors of AKAP complexes. ACS Chem Biol 10:1502–1510
126. Araghi RR, Ryan JA, Letai A, Keating AE (2016) Rapid optimization of Mcl-1 inhibitors using
stapled peptide libraries including non-natural side chains. ACS Chem Biol 11:1238–1244
127. Teng Y, Bahassan A, Dong DY, Hanold LE, Ren XO, Kennedy EJ, Cowell JK (2016) Targeting
the WASF3-CYFIP1 complex Using stapled peptides suppresses Cancer cell invasion. Cancer
Res 76:965–973