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References
Akhtar MJ, Ahamed M, Khan MA, Alrokayan SA, Ahmad I, Kumar S (2014) Cytotoxicity and
apoptosis induction by nanoscale talc particles from two different geographical regions in
human lung epithelial cells. Environ Toxicol 29:394–406
Aranda A, Sequedo L, Tolosa L, Quintas G, Burello E, Castell JV, Gombau L (2013) Dichlorodihydro- fluorescein diacetate (DCFH-DA) assay: a quantitative method for oxidative stress
assessment of nanoparticle-treated cells. Toxicol in Vitro 27:954–963
Azhdarzadeh M, Saei AA, Sharifi S, Hajipour MJ, Alkilany AM, Sharifzadeh M, Ramazani F,
Laurent S, Mashaghi A, Mahmoudi M (2015) Nanotoxicology: advances and pitfalls in
research methodology. Nanomedicine (London) 10:2931–2952
Bastús NG, Puntes V (2017) Nanosafety: towards safer nanoparticles by design. Curr Med Chem
Benetti F, Bregoli L, Olivato I, Sabbioni E (2014) Effects of metal(loid)-based nanomaterials
on essential element homeostasis: the central role of nanometallomics for nanotoxicology.
Metallomics 6:729–747
Bhattacharjee S, Rietjens IM, Singh MP, Atkins TM, Purkait TK, Xu Z, Regli S, Shukaliak A,
Clark RJ, Mitchell BS, Alink GM, Marcelis AT, Fink MJ, Veinot JG, Kauzlarich SM, Zuilhof H
(2013) Cytotoxicity of surface-functionalized silicon and germanium nanoparticles: the dominant role of surface charges. Nanoscale 5:4870–4883
Bilia AR, Guccione C, Isacchi B, Righeschi C, Firenzuoli F, Bergonzi MC (2014) Essential oils
loaded in nanosystems: a developing strategy for a successful therapeutic approach. Evid
Based Complement Altern Med 2014:651593
Blanco E, Shen H, Ferrari M (2015) Principles of nanoparticle design for overcoming biological
barriers to drug delivery. Nat Biotechnol 33:941–951
Bouwmeester H, Poortman J, Peters RJ, Wijma E, Kramer E, Makama S, Puspitaninganindita K,
Marvin HJ, Peijnenburg AA, Hendriksen PJ (2011) Characterization of translocation of silver
nanoparticles and effects on whole-genome gene expression using an in vitro intestinal epithelium coculture model. ACS Nano 5:4091–4103
Branica G, Mladinić M, Omanović D, Želježić D (2016) An alternative approach to studying the
effects of ZnO nanoparticles in cultured human lymphocytes: combining electrochemistry and
genotoxicity tests. Arh Hig Rada Toksikol 67:277–288
Bunaciu AA, Fleschin Ş, Aboul-Enein HY (2014) Biomedical investigations using Fourier
transform- infrared microspectroscopy. Crit Rev Anal Chem 44:270–276
Burlinson B (2012) The in vitro and in vivo comet assays. Methods Mol Biol 817:143–163
Caballero-Diaz E, Cases M (2016) Analytical methodologies for nanotoxicity assessment. TracTrends Anal Chem 84:160–171
Calvano CD, De Ceglie C, Zambonin CG (2014) Proteomic analysis of complex protein samples
by MALDI-TOF mass spectrometry. Methods Mol Biol 1129:365–380
Cattaneo AG, Gornati R, Sabbioni E, Chiriva-Internati M, Cobos E, Jenkins MR, Bernardini G
(2010) Nanotechnology and human health: risks and benefits. J Appl Toxicol 30:730–744
Chueh PJ, Liang RY, Lee YH, Zeng ZM, Chuang SM (2014) Differential cytotoxic effects of gold
nanoparticles in different mammalian cell lines. J Hazard Mater 264:303–312
Ciappellano SG, Tedesco E, Venturini M, Benetti F (2016) In vitro toxicity assessment of oral
nanocarriers. Adv Drug Deliv Rev 106:381–401
Cole JT, Holland NB (2015) Multifunctional nanoparticles for use in theranostic applications.
Drug Deliv Transl Res 5:295–309
Costa C, Brandão F, Bessa MJ, Costa S, Valdiglesias V, Kiliç G, Fernández-Bertólez N, Quaresma
P, Pereira E, Pásaro E, Laffon B, Teixeira JP (2016) In vitro cytotoxicity of superparamagnetic
iron oxide nanoparticles on neuronal and glial cells. Evaluation of nanoparticle interference
with viability tests. J Appl Toxicol 36:361–372
Crow JP (1997) Dichlorodihydrofluorescein and dihydrorhodamine 123 are sensitive indicators
of peroxynitrite in vitro: implications for intracellular measurement of reactive nitrogen and
oxygen species. Nitric Oxide 1:145–157
M. C. Teixeira et al.
References
Akhtar MJ, Ahamed M, Khan MA, Alrokayan SA, Ahmad I, Kumar S (2014) Cytotoxicity and
apoptosis induction by nanoscale talc particles from two different geographical regions in
human lung epithelial cells. Environ Toxicol 29:394–406
Aranda A, Sequedo L, Tolosa L, Quintas G, Burello E, Castell JV, Gombau L (2013) Dichlorodihydro- fluorescein diacetate (DCFH-DA) assay: a quantitative method for oxidative stress
assessment of nanoparticle-treated cells. Toxicol in Vitro 27:954–963
Azhdarzadeh M, Saei AA, Sharifi S, Hajipour MJ, Alkilany AM, Sharifzadeh M, Ramazani F,
Laurent S, Mashaghi A, Mahmoudi M (2015) Nanotoxicology: advances and pitfalls in
research methodology. Nanomedicine (London) 10:2931–2952
Bastús NG, Puntes V (2017) Nanosafety: towards safer nanoparticles by design. Curr Med Chem
Benetti F, Bregoli L, Olivato I, Sabbioni E (2014) Effects of metal(loid)-based nanomaterials
on essential element homeostasis: the central role of nanometallomics for nanotoxicology.
Metallomics 6:729–747
Bhattacharjee S, Rietjens IM, Singh MP, Atkins TM, Purkait TK, Xu Z, Regli S, Shukaliak A,
Clark RJ, Mitchell BS, Alink GM, Marcelis AT, Fink MJ, Veinot JG, Kauzlarich SM, Zuilhof H
(2013) Cytotoxicity of surface-functionalized silicon and germanium nanoparticles: the dominant role of surface charges. Nanoscale 5:4870–4883
Bilia AR, Guccione C, Isacchi B, Righeschi C, Firenzuoli F, Bergonzi MC (2014) Essential oils
loaded in nanosystems: a developing strategy for a successful therapeutic approach. Evid
Based Complement Altern Med 2014:651593
Blanco E, Shen H, Ferrari M (2015) Principles of nanoparticle design for overcoming biological
barriers to drug delivery. Nat Biotechnol 33:941–951
Bouwmeester H, Poortman J, Peters RJ, Wijma E, Kramer E, Makama S, Puspitaninganindita K,
Marvin HJ, Peijnenburg AA, Hendriksen PJ (2011) Characterization of translocation of silver
nanoparticles and effects on whole-genome gene expression using an in vitro intestinal epithelium coculture model. ACS Nano 5:4091–4103
Branica G, Mladinić M, Omanović D, Želježić D (2016) An alternative approach to studying the
effects of ZnO nanoparticles in cultured human lymphocytes: combining electrochemistry and
genotoxicity tests. Arh Hig Rada Toksikol 67:277–288
Bunaciu AA, Fleschin Ş, Aboul-Enein HY (2014) Biomedical investigations using Fourier
transform- infrared microspectroscopy. Crit Rev Anal Chem 44:270–276
Burlinson B (2012) The in vitro and in vivo comet assays. Methods Mol Biol 817:143–163
Caballero-Diaz E, Cases M (2016) Analytical methodologies for nanotoxicity assessment. TracTrends Anal Chem 84:160–171
Calvano CD, De Ceglie C, Zambonin CG (2014) Proteomic analysis of complex protein samples
by MALDI-TOF mass spectrometry. Methods Mol Biol 1129:365–380
Cattaneo AG, Gornati R, Sabbioni E, Chiriva-Internati M, Cobos E, Jenkins MR, Bernardini G
(2010) Nanotechnology and human health: risks and benefits. J Appl Toxicol 30:730–744
Chueh PJ, Liang RY, Lee YH, Zeng ZM, Chuang SM (2014) Differential cytotoxic effects of gold
nanoparticles in different mammalian cell lines. J Hazard Mater 264:303–312
Ciappellano SG, Tedesco E, Venturini M, Benetti F (2016) In vitro toxicity assessment of oral
nanocarriers. Adv Drug Deliv Rev 106:381–401
Cole JT, Holland NB (2015) Multifunctional nanoparticles for use in theranostic applications.
Drug Deliv Transl Res 5:295–309
Costa C, Brandão F, Bessa MJ, Costa S, Valdiglesias V, Kiliç G, Fernández-Bertólez N, Quaresma
P, Pereira E, Pásaro E, Laffon B, Teixeira JP (2016) In vitro cytotoxicity of superparamagnetic
iron oxide nanoparticles on neuronal and glial cells. Evaluation of nanoparticle interference
with viability tests. J Appl Toxicol 36:361–372
Crow JP (1997) Dichlorodihydrofluorescein and dihydrorhodamine 123 are sensitive indicators
of peroxynitrite in vitro: implications for intracellular measurement of reactive nitrogen and
oxygen species. Nitric Oxide 1:145–157
M. C. Teixeira et al.