139
© The Editor(s) (if applicable) and The Author(s), under exclusive license to
Springer Nature Switzerland AG 2021
V. Kumar et al. (eds.), Nanotoxicology and Nanoecotoxicology Vol. 1,
Environmental Chemistry for a Sustainable World 59,
https://doi.org/10.1007/978-3-030-63241-0_6
Chapter 6
Exploring Microbial Nanotoxicity Against
Drug Resistance in Bacteria
Rajeshwari Sinha, Ayesha Sadaf, and Sunil K. Khare
Contents
6.1 Introduction
140
6.2 Effect of Nanoparticles on Drug-Resistant Bacteria
141
6.2.1 Effects of Chemically Synthesized Nanoparticles
on Drug-Resistant Bacteria
142
6.2.2 Effect of Biologically Synthesized Nanoparticles
on Drug-Resistant Bacteria
144
6.2.3 Effect of Functionalized Nanoparticles on Drug-Resistant Bacteria
149
6.3 Mechanism of Nanoparticle-Mediated Toxicity to Control
Antibiotic-Resistant Bacteria
152
6.4 Advances in Addressing Antimicrobial Resistance by Nanoparticle-Mediated
Approaches
155
6.5 Conclusions and Future Perspectives
162
References
162
Abstract The growing threat of antimicrobial resistance on human health urgently
calls for the need to look for novel solutions to mitigate the grave effect of this
global problem and save thousands of lives each year. Nanotechnology is an emerging area that is expected to be able to have solutions toward containing the rise and
spread of multidrug-resistant microorganisms. The present chapter focuses on
understanding the potential of nanomaterials to cope with drug-resistant bacteria.
While different types of nanoparticles have emerged as nanoweapons against drugresistant or multidrug-resistant bacteria, other nanomaterials like quantum dots,
nanotubes, dendrimers, fullerenes, and nanoparticle-conjugated antimicrobial peptides or antibiotics are being explored in parallel for their antimicrobial properties.
The chapter looks at interactions between nanomaterials and drug-resistant microbes
R. Sinha
Independent Researcher, New Delhi, India
A. Sadaf · S. K. Khare (*)
Enzyme and Microbial Biochemistry Laboratory, Department of Chemistry, Indian Institute
of Technology Deli, New Delhi, India
e-mail: skkhare@chemistry.iitd.ac.in
© The Editor(s) (if applicable) and The Author(s), under exclusive license to
Springer Nature Switzerland AG 2021
V. Kumar et al. (eds.), Nanotoxicology and Nanoecotoxicology Vol. 1,
Environmental Chemistry for a Sustainable World 59,
https://doi.org/10.1007/978-3-030-63241-0_6
Chapter 6
Exploring Microbial Nanotoxicity Against
Drug Resistance in Bacteria
Rajeshwari Sinha, Ayesha Sadaf, and Sunil K. Khare
Contents
6.1 Introduction
140
6.2 Effect of Nanoparticles on Drug-Resistant Bacteria
141
6.2.1 Effects of Chemically Synthesized Nanoparticles
on Drug-Resistant Bacteria
142
6.2.2 Effect of Biologically Synthesized Nanoparticles
on Drug-Resistant Bacteria
144
6.2.3 Effect of Functionalized Nanoparticles on Drug-Resistant Bacteria
149
6.3 Mechanism of Nanoparticle-Mediated Toxicity to Control
Antibiotic-Resistant Bacteria
152
6.4 Advances in Addressing Antimicrobial Resistance by Nanoparticle-Mediated
Approaches
155
6.5 Conclusions and Future Perspectives
162
References
162
Abstract The growing threat of antimicrobial resistance on human health urgently
calls for the need to look for novel solutions to mitigate the grave effect of this
global problem and save thousands of lives each year. Nanotechnology is an emerging area that is expected to be able to have solutions toward containing the rise and
spread of multidrug-resistant microorganisms. The present chapter focuses on
understanding the potential of nanomaterials to cope with drug-resistant bacteria.
While different types of nanoparticles have emerged as nanoweapons against drugresistant or multidrug-resistant bacteria, other nanomaterials like quantum dots,
nanotubes, dendrimers, fullerenes, and nanoparticle-conjugated antimicrobial peptides or antibiotics are being explored in parallel for their antimicrobial properties.
The chapter looks at interactions between nanomaterials and drug-resistant microbes
R. Sinha
Independent Researcher, New Delhi, India
A. Sadaf · S. K. Khare (*)
Enzyme and Microbial Biochemistry Laboratory, Department of Chemistry, Indian Institute
of Technology Deli, New Delhi, India
e-mail: skkhare@chemistry.iitd.ac.in