3.5 α-Acylation of Unsaturated Nitriles
Szymczak and co-workers reported the hydrogenative acylation of α,β-unsaturated
nitriles catalysed by a ruthenium pincer complex [53]. The reaction, which was
performed with 4 eq. of the anhydride, complex 28 as catalyst at 100
C and 7 bar H 2 ,
using toluene as solvent and DBU as base, resulted in the desired products in good to
excellent yields (Table 13). The reaction worked well on aliphatic as well as benzylic
nitriles, and electron-donating as well as electron-withdrawing substituents on the
Scheme 27 Proposed mechanism for the α-deuteration of aliphatic nitriles catalysed by 19
350
B. Guo et al.
Szymczak and co-workers reported the hydrogenative acylation of α,β-unsaturated
nitriles catalysed by a ruthenium pincer complex [53]. The reaction, which was
performed with 4 eq. of the anhydride, complex 28 as catalyst at 100
C and 7 bar H 2 ,
using toluene as solvent and DBU as base, resulted in the desired products in good to
excellent yields (Table 13). The reaction worked well on aliphatic as well as benzylic
nitriles, and electron-donating as well as electron-withdrawing substituents on the
Scheme 27 Proposed mechanism for the α-deuteration of aliphatic nitriles catalysed by 19
350
B. Guo et al.