The group of Sortais introduced a procedure for α-methylation of various ketones
using methanol as building block. Substrates, containing carbon on the α-position,
were selectively mono-methylated. Remarkably, in the absence of a substituent at
the α-position, double methylation could be achieved (Scheme 45) [78].
3.7.1 Alkylation of Amides and Esters
Milstein and coworkers employed Mn26 for the α-alkylation of amides and esters
with primary alcohols. High catalyst loading (5 mol%), an over-stoichiometric
amount of base, and four equivalents of esters or two equivalents of amide were
necessary to achieve good yields [75].
El-Sepelgy, Rueping, and coworkers investigated the role of PNP- and
PNN-supported systems for the alkylation of amides and esters. Mn33 showed
Scheme 43 β-alkylation of alcohols catalyzed by Mn(I) catalysts utilizing HB reactions
254
S. Weber and K. Kirchner
using methanol as building block. Substrates, containing carbon on the α-position,
were selectively mono-methylated. Remarkably, in the absence of a substituent at
the α-position, double methylation could be achieved (Scheme 45) [78].
3.7.1 Alkylation of Amides and Esters
Milstein and coworkers employed Mn26 for the α-alkylation of amides and esters
with primary alcohols. High catalyst loading (5 mol%), an over-stoichiometric
amount of base, and four equivalents of esters or two equivalents of amide were
necessary to achieve good yields [75].
El-Sepelgy, Rueping, and coworkers investigated the role of PNP- and
PNN-supported systems for the alkylation of amides and esters. Mn33 showed
Scheme 43 β-alkylation of alcohols catalyzed by Mn(I) catalysts utilizing HB reactions
254
S. Weber and K. Kirchner