18
2 A New View on Mechanism of Functional Expression …
(a)
(b)
Solute molecules
Water molecule
Fig. 2.8 Energetic (a) and entropic (b) aspects of binding of two solute molecules in water. In (a),
the water molecules marked in blue are released to the bulk upon the binding with the result that
some of the water-water hydrogen bonds are recovered. In (b), “EV” denotes the excluded volume.
(Reproduced and modified from Ref. 24 with permission from the PCCP Owner Societies)
outlined in Chap. 6, we showed that the penalty is often larger than the decrease as
exemplified in a protein-peptide binding process [24]).
The energetic dehydration penalty comprises its electrostatic (ES) and van der
Waals (vdW) components. The penalty explained above is the ES component. The
conformational energy of solute molecules also comprises its ES and vdW components. The binding is accompanied by not only a decrease in the vdW component of
conformational energy but also the vdW component of the penalty arising from the
loss of solute-water vdW interaction. For the binding of an oncoprotein (MDM2) and
2 A New View on Mechanism of Functional Expression …
(a)
(b)
Solute molecules
Water molecule
Fig. 2.8 Energetic (a) and entropic (b) aspects of binding of two solute molecules in water. In (a),
the water molecules marked in blue are released to the bulk upon the binding with the result that
some of the water-water hydrogen bonds are recovered. In (b), “EV” denotes the excluded volume.
(Reproduced and modified from Ref. 24 with permission from the PCCP Owner Societies)
outlined in Chap. 6, we showed that the penalty is often larger than the decrease as
exemplified in a protein-peptide binding process [24]).
The energetic dehydration penalty comprises its electrostatic (ES) and van der
Waals (vdW) components. The penalty explained above is the ES component. The
conformational energy of solute molecules also comprises its ES and vdW components. The binding is accompanied by not only a decrease in the vdW component of
conformational energy but also the vdW component of the penalty arising from the
loss of solute-water vdW interaction. For the binding of an oncoprotein (MDM2) and