4
1 Introduction
direction under the solution condition that the ATP hydrolysis reaction occurs; (B)
rotation in the inverse direction under the solution condition that the ATP synthesis
reaction occurs; (C) rotations in random directions under the solution condition that
the ATP hydrolysis and synthesis reactions are in equilibrium; and (D) occurrence
of ATP synthesis, even under the solution condition that the ATP hydrolysis reaction
should occur, through forcible rotation in the inverse direction by means of sufficiently strong external torque imposed on the γ subunit. Scenarios (B) and (C) have
not yet been corroborated in experiments but should actually happen in our view.
F 1 -ATPase was considered in our two papers [15, 16] and the first book [9], but only
scenario (A) was treated, and besides, just in a preliminary form. Many of the ideas
described in this book have newly been developed by the author.
References
1. Shimabukuro K, Yasuda R, Muneyuki E, Hara KY, Kinosita K Jr, Yoshida M (2003) Proc Natl
Acad Sci USA 100:14731
2. Adachi K, Oiwa K, Nishizaka T, Furuike S, Noji H, Itoh H, Yoshida M, Kinosita K Jr (2007)
Cell 130:309
3. Kitamura K, Tokunaga M, Iwane AH, Yanagida T (1999) Nature 397:129
4. Kitamura K, Tokunaga M, Esaki S, Iwane AH, Yanagida T (2005) Biophysics 1:1
5. Ward A, Reyes CL, Yu J, Roth CB, Chang G (2007) Proc Natl Acad Sci USA 104:19005
6. Hollenstein K, Dawson RJP, Locher KP (2007) Curr Opin Struct Biol 17:412
7. Noji H, Yasuda R, Yoshida M, Kinosita K Jr (1997) Nature 386:299
8. Ananthakrishnan R, Ehrlichter A (2007) Int J Biol Sci 3:303
9. Kinoshita M (2016) Mechanism of functional expression of the molecular machines. Springer
Briefs in Molecular Science, Springer, ISBN: 978-981-10-1484-0
10. Kinoshita M (2018) Functioning mechanism of ATP-driven proteins inferred on the basis of
water-entropy effect. In: Suzuki M (ed) The role of water in ATP hydrolysis energy transduction
by protein machinery. Chapter 18, Part III, Springer Briefs in Molecular Science, Springer,
ISBN: 978-981-10-8458-4, pp 303–323
11. Kinoshita M (2003) Surface-induced phase transition and long-range surface force: roles in
colloidal and biological systems. Transworld Research Network, India, ISBN: 81-7895-113-4,
Vol. 1, Recent Research Developments in Molecular Physics, pp 21–41
12. Kinoshita M (2009) Front Biosci 14:3419
13. Kinoshita M (2009) Int J Mol Sci 10:1064
14. Kinoshita M (2013) Biophys Rev 5:283
15. Yoshidome T, Ito Y, Ikeguchi M, Kinoshita M (2011) J Am Chem Soc 133:4030
16. Yoshidome T, Ito Y, Matubayasi N, Ikeguchi M, Kinoshita M (2012) J Chem Phys 137:035102
1 Introduction
direction under the solution condition that the ATP hydrolysis reaction occurs; (B)
rotation in the inverse direction under the solution condition that the ATP synthesis
reaction occurs; (C) rotations in random directions under the solution condition that
the ATP hydrolysis and synthesis reactions are in equilibrium; and (D) occurrence
of ATP synthesis, even under the solution condition that the ATP hydrolysis reaction
should occur, through forcible rotation in the inverse direction by means of sufficiently strong external torque imposed on the γ subunit. Scenarios (B) and (C) have
not yet been corroborated in experiments but should actually happen in our view.
F 1 -ATPase was considered in our two papers [15, 16] and the first book [9], but only
scenario (A) was treated, and besides, just in a preliminary form. Many of the ideas
described in this book have newly been developed by the author.
References
1. Shimabukuro K, Yasuda R, Muneyuki E, Hara KY, Kinosita K Jr, Yoshida M (2003) Proc Natl
Acad Sci USA 100:14731
2. Adachi K, Oiwa K, Nishizaka T, Furuike S, Noji H, Itoh H, Yoshida M, Kinosita K Jr (2007)
Cell 130:309
3. Kitamura K, Tokunaga M, Iwane AH, Yanagida T (1999) Nature 397:129
4. Kitamura K, Tokunaga M, Esaki S, Iwane AH, Yanagida T (2005) Biophysics 1:1
5. Ward A, Reyes CL, Yu J, Roth CB, Chang G (2007) Proc Natl Acad Sci USA 104:19005
6. Hollenstein K, Dawson RJP, Locher KP (2007) Curr Opin Struct Biol 17:412
7. Noji H, Yasuda R, Yoshida M, Kinosita K Jr (1997) Nature 386:299
8. Ananthakrishnan R, Ehrlichter A (2007) Int J Biol Sci 3:303
9. Kinoshita M (2016) Mechanism of functional expression of the molecular machines. Springer
Briefs in Molecular Science, Springer, ISBN: 978-981-10-1484-0
10. Kinoshita M (2018) Functioning mechanism of ATP-driven proteins inferred on the basis of
water-entropy effect. In: Suzuki M (ed) The role of water in ATP hydrolysis energy transduction
by protein machinery. Chapter 18, Part III, Springer Briefs in Molecular Science, Springer,
ISBN: 978-981-10-8458-4, pp 303–323
11. Kinoshita M (2003) Surface-induced phase transition and long-range surface force: roles in
colloidal and biological systems. Transworld Research Network, India, ISBN: 81-7895-113-4,
Vol. 1, Recent Research Developments in Molecular Physics, pp 21–41
12. Kinoshita M (2009) Front Biosci 14:3419
13. Kinoshita M (2009) Int J Mol Sci 10:1064
14. Kinoshita M (2013) Biophys Rev 5:283
15. Yoshidome T, Ito Y, Ikeguchi M, Kinoshita M (2011) J Am Chem Soc 133:4030
16. Yoshidome T, Ito Y, Matubayasi N, Ikeguchi M, Kinoshita M (2012) J Chem Phys 137:035102