Table 6
Freeze-dried protein drugs commercially available with their incorporated excipients [9]
Brand
name
Generic name
Excipients
Abbokinase Urokinase
Mannitol, sodium chloride, human serum albumin
Activase
Alteplase
L-Arginine, polysorbate 80, phosphoric acid
Advate
Antihemophilic factor
Mannitol, trehalose, sodium, histidine, Tris, calcium,
polysorbate 80, glutathione
Aralast
Alpha1 proteinase inhibitor
Albumin, polyethylene glycol, polysorbate
80, sodium tri-n-butyl phosphate, zinc
Autoplex T Anti-inhibitor coagulant complex
vitamin K-dependent clotting
factors
Polyethylene glycol, sodium citrate
Avonex
Interferon beta-1a
Human albumin, sodium chloride, sodium
phosphate monobasic, sodium phosphate dibasic
BabyBIG
Botulism immune globulin
Human albumin, sucrose
BeneFix
Coagulation factor IX
Histidine, sucrose, glycine, polysorbate 80
Betaseron Interferon beta-1b
Human serum albumin, mannitol
CroFab
Crotalidae polyvalent immune Fab Sodium phosphate dibasic, sodium chloride,
thimerosal
DigiFab
Digoxin immune Fab
Mannitol, sodium acetate
ElitekTM
Rasburicase
Mannitol, L-alanine, sodium phosphate dibasic,
poloxamer 188
Elspar
Asparaginase
Mannitol
Enbrel
Etanercept
Mannitol, sucrose, tromethamine
Genotropin Human growth hormone
Glycine, sodium dihydrogen phosphate anhydrous,
disodium phosphate anhydrous
Geref
Ampuls
Sermorelin acetate
Mannitol, sodium phosphate monobasic, sodium
phosphate dibasic
GlucaGen Glucagon
Lactose monohydrate
Glucagon
Glucagon
Lactose
Hemofil M Antihemophilic factor
Albumin, polyethylene glycol, histidine, glycine,
mouse protein Tri-n-butyl phosphate, oxtocynol 9
Herceptin Trastuzumab
L-Histidine hydrochloride, L-histidine, trehalose,
polysorbate 20
Humate-P Antihemophilic factor
Glycine, sodium citrate, sodium chloride
Humatrope Human growth hormone
Mannitol, glycine, sodium phosphate dibasic, metacresol, glycerin
(continued)
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Baolin Liu and Xinli Zhou