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114. Y. Ishii-Osai, T. Yamashita, Y. Tamura, N. Sato, A. Ito, H. Honda, K. Wakamatsu, S. Ito,
E. Nakayama, M. Okura, K. Jimbow, N-propionyl-4-S-cysteaminylphenol induces apoptosis
in B16F1 cells and mediates tumor-specific T-cell immune responses in a mouse melanoma
model. J. Dermatol. Sci. 67, 51–60 (2012)
115. M. Sasaki, M. Kondo, K. Sato, M. Umeda, K. Kawabata, Y. Takahashi, T. Suzuki, K. Matunaga,
S. Inoue, Rhododendrol a depigmentation-inducing phenolic compound exerts melanocyte
cytotoxicity via a tyrosinase-dependent mechanism. Pigment Cell Melanoma Res. 27, 754–
763 (2014)
116. E. Karg, E. Rosengren, H. Rorsman, Hydrogen peroxide as a mediator of dopac-induced
effects on melanoma cells. J. Invest. Dermatol. 96, 224–227 (1991)
117. S. Ito, M. Okura, Y. Nakanishi, M. Ojika, K. Wakamatsu, T. Yamashita, Tyrosinase-catalyzed
metabolism of rhododendrol (RD) in B16 melanoma cells: production of RD-pheomelanin
and covalent binding with thiol proteins. Pigment Cell Melanoma Res. 28, 295–306 (2015)
118. A. Napolitano, L. Panzella, G. Monfrecola, Pheomelanin-induced oxidative stress: bright and
dark chemistry bridging red hair phenotype and melanoma. Pigment Cell Melanoma Res. 27,
721–733 (2014)
119. L. Panzella, L. Leone, G. Greco, G. Vitiello, G. D’Errico, A. Napolitano, M. d’Ischia, Red
human hair pheomelanin is a potent pro-oxidant mediating UV-independent contributory
mechanisms of melanomagenesis. Photochem. Photobiol. 82, 733–737 (2006)
120. T. Ye, L. Hong, J. Garguilo, A. Pawlak, G.S. Edwards, R.J. Nemanich, T. Sarna, J.D. Simon,
Photoionization thresholds of melanins obtained from free electron laser-photoelectron emission microscopy femtosecond transient absorption spectroscopy and electron paramagnetic
resonance measurements of oxygen photoconsumption. Pigment Cell Melanoma Res. 28,
295–306 (2015)
121. W. Westerhof, P. Manini, A. Napolitano, M. d’Ischia, The haptenation theory of vitiligo and
melanoma rejection: a close-up. Exp. Dermatol. 20, 92–96 (2011)
122. T. Passeron, J.-P. Ortonne, Activation of the unfolded protein response in vitiligo: the missing
link? J. Invest. Dermatol. 132, 2502–2504 (2012)
123. R. Kishida, Y. Ushijima, A.G. Saputro, H. Kasai, Effect of pH on elementary steps of
dopachrome conversion from first-principles calculation. Pigment Cell Melanoma Res. 27,
734–743 (2014)
124. R. Kishida, A.G. Saputro, H. Kasai, Mechanism of dopachrome tautomerization into
5,6-dihydroxyindole-2-carboxylic acid catalyzed by Cu(II) based on quantum chemical
calculations. Biochim. Biophys. Acta 2015, 281–286 (1850)
125. R. Kishida, H. Kasai, S.M. Aspera, R.L. Arevalo, H. Nakanishi, Branching reaction in melanogenesis: the effect of intramolecular cyclization on thiol binding. J. Electron. Mater. 46,
3784–3788 (2017)
126. R. Kishida, H. Kasai, S.M. Aspera, R.L. Arevalo, H. Nakanishi, Density functional theorybased first principles calculations of rhododendrol-quinone reactions: preference to thiol
binding over cyclization. J. Phys. Soc. Jpn. 86, 024804-1-5 (2017)
127. R. Kishida, A.G. Saputro, R.L. Arevalo, H. Kasai, Effects of introduction of α-carboxylate
N-methyl and N-formyl groups on intramolecular cyclization of o-quinone amines: density
functional theory-based study. Int. J. Quant. Chem. 117, e25445-1-9 (2017)