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G Case Study Solutions
Table G.3
Possible results for a qualitative probability analysis of the synthesis reaction and work-up of 3-amino-2-isopropylthio benzonitrile. The qualitative
estimate of probability for each entry is shown in italics. Note that this does not represent an exhaustive list
Process failure
Process deviation
Safeguard failure
(preventive)
Loss event
Safeguard failure
(mitigative)
Consequence
• Failure of
• Temperature too
• Failure of
• Thermal runaway
• Depressurization/
• HCN release
temperature
high (medium)
temperature alarm
(medium)
rupture disk activation
(medium)
measurement
(medium)
(medium)
(medium)
• Stirrer failure
• Pressure too high
(medium)
(medium)
• Reflux failure
(medium)
• Operator failure
(medium)
• Flowmeter failure
(medium)
• Failure in the
electricity supply
(medium)