10.2 Process Risk Assessment
245
Table 10.4
Incomplete table showing results of a HAZOP study of the synthesis and work-up reaction of 3-amino-2-isopropylthio benzonitrile. Note that
this table is not exhaustive, and other process conditions, deviations, and hazards, etc. could be considered
Item
Process conditions ⊥
Deviation
Process hazard
Process failure
Loss event
Safeguards Consequences
Synthesis
reaction
Process temperature
= 190 ◦
C
High temperature
?
?
Thermal
runaway
?
HCN release
Synthesis
reaction
Atmospheric pressure
High pressure
?
?
Rupture/crack
hole in reactor
?
HCN release
Precipitation
reaction
Feed flow (Na
2 S)
approximately
105 kg/hr a
; Process
temperature
= 65 ◦
C
High feed flow
(semi-batch); high
temperature
?
?
Thermal
runaway
?
HCN release
⊥
3-Chloro-2-isopropylthio aniline reaches the flash point at reaction conditions
a
Depending on the temperature control loop
245
Table 10.4
Incomplete table showing results of a HAZOP study of the synthesis and work-up reaction of 3-amino-2-isopropylthio benzonitrile. Note that
this table is not exhaustive, and other process conditions, deviations, and hazards, etc. could be considered
Item
Process conditions ⊥
Deviation
Process hazard
Process failure
Loss event
Safeguards Consequences
Synthesis
reaction
Process temperature
= 190 ◦
C
High temperature
?
?
Thermal
runaway
?
HCN release
Synthesis
reaction
Atmospheric pressure
High pressure
?
?
Rupture/crack
hole in reactor
?
HCN release
Precipitation
reaction
Feed flow (Na
2 S)
approximately
105 kg/hr a
; Process
temperature
= 65 ◦
C
High feed flow
(semi-batch); high
temperature
?
?
Thermal
runaway
?
HCN release
⊥
3-Chloro-2-isopropylthio aniline reaches the flash point at reaction conditions
a
Depending on the temperature control loop