of cardiac targeting peptide as a cardiac vector (Cardiac-specific
protein targeting domain, U.S. Patent Serial No. 9,249,184).
M.Z. also serves as Chief Scientific Officer and on the Board of
Directors of the startup Vivasc Therapeutics Inc., and holds substantial equity in it. M.P. is the Chief Scientific Officer of Dualsystems Biotech AG that holds an exclusive license for the LRC
technology as covered in patent application WO2012/104051.
References
1. Green M, Loewenstein PM (1988) Autonomous functional domains of chemically synthesized human immunodeficiency virus tat transactivator protein. Cell 55:1179–1188
2. Frankel AD, Pabo CO (1988) Cellular uptake
of the tat protein from human immunodeficiency virus. Cell 55:1189–1193
3. Joliot A, Pernelle C, Deagostini-Bazin H, Prochiantz A (1991) Antennapedia homeobox
peptide regulates neural morphogenesis. Proc
Natl Acad Sci U S A 88:1864–1868
4. Schwarze SR, Ho A, Vocero-Akbani A, Dowdy
SF (1999) In vivo protein transduction: delivery of a biologically active protein into the
mouse. Science 285:1569–1572
5. Zahid M, Robbins PD (2015) Cell-type specific penetrating peptides: therapeutic promises
and challenges. Molecules 20:13055–13070
6. Ramsey JD, Flynn NH (2015) Cellpenetrating peptides transport therapeutics
into cells. Pharmacol Ther 154:78–86
7. Zahid M, Robbins PD (2011) Identification
and characterization of tissue-specific protein
transduction domains using peptide phage display. Methods Mol Biol 683:277–289
8. Zahid M, Phillips BE, Albers SM,
Giannoukakis N, Watkins SC, Robbins PD
(2010) Identification of a cardiac specific protein transduction domain by in vivo biopanning using a M13 phage peptide display
library in mice. PLoS One 5:e12252
9. Zahid M, Feldman KS, Garcia-Borrero G et al
(2018) Cardiac targeting peptide, a novel cardiac vector: studies in bio-distribution, imaging
application,
and
mechanism
of
transduction. Biomol Ther 8(4):147
10. Frei AP, Moest H, Novy K, Wollscheid B
(2013) Ligand-based receptor identification
on living cells and tissues using TRICEPS.
Nat Protoc 8:1321–1336
11. Sobotzki N, Schafroth MA, Rudnicka A et al
(2018) HATRIC-based identification of receptors for orphan ligands. Nat Commun 9:1519
12. Choi M, Chang CY, Clough T et al (2014)
MSstats: an R package for statistical analysis of
quantitative mass spectrometry-based proteomic
experiments.
Bioinformatics
30:2524–2526
13. Timo Glatter T, Christina Ludwig C, Ahrne ´ E
et al (2012) Large-scale quantitative assessment of different in-solution protein digestion
protocols reveals superior cleavage efficiency of
tandem Lys-C/trypsin proteolysis over trypsin
digestion. J Proteome Res 11:5145–5156
112
Kyle S. Feldman et al.
protein targeting domain, U.S. Patent Serial No. 9,249,184).
M.Z. also serves as Chief Scientific Officer and on the Board of
Directors of the startup Vivasc Therapeutics Inc., and holds substantial equity in it. M.P. is the Chief Scientific Officer of Dualsystems Biotech AG that holds an exclusive license for the LRC
technology as covered in patent application WO2012/104051.
References
1. Green M, Loewenstein PM (1988) Autonomous functional domains of chemically synthesized human immunodeficiency virus tat transactivator protein. Cell 55:1179–1188
2. Frankel AD, Pabo CO (1988) Cellular uptake
of the tat protein from human immunodeficiency virus. Cell 55:1189–1193
3. Joliot A, Pernelle C, Deagostini-Bazin H, Prochiantz A (1991) Antennapedia homeobox
peptide regulates neural morphogenesis. Proc
Natl Acad Sci U S A 88:1864–1868
4. Schwarze SR, Ho A, Vocero-Akbani A, Dowdy
SF (1999) In vivo protein transduction: delivery of a biologically active protein into the
mouse. Science 285:1569–1572
5. Zahid M, Robbins PD (2015) Cell-type specific penetrating peptides: therapeutic promises
and challenges. Molecules 20:13055–13070
6. Ramsey JD, Flynn NH (2015) Cellpenetrating peptides transport therapeutics
into cells. Pharmacol Ther 154:78–86
7. Zahid M, Robbins PD (2011) Identification
and characterization of tissue-specific protein
transduction domains using peptide phage display. Methods Mol Biol 683:277–289
8. Zahid M, Phillips BE, Albers SM,
Giannoukakis N, Watkins SC, Robbins PD
(2010) Identification of a cardiac specific protein transduction domain by in vivo biopanning using a M13 phage peptide display
library in mice. PLoS One 5:e12252
9. Zahid M, Feldman KS, Garcia-Borrero G et al
(2018) Cardiac targeting peptide, a novel cardiac vector: studies in bio-distribution, imaging
application,
and
mechanism
of
transduction. Biomol Ther 8(4):147
10. Frei AP, Moest H, Novy K, Wollscheid B
(2013) Ligand-based receptor identification
on living cells and tissues using TRICEPS.
Nat Protoc 8:1321–1336
11. Sobotzki N, Schafroth MA, Rudnicka A et al
(2018) HATRIC-based identification of receptors for orphan ligands. Nat Commun 9:1519
12. Choi M, Chang CY, Clough T et al (2014)
MSstats: an R package for statistical analysis of
quantitative mass spectrometry-based proteomic
experiments.
Bioinformatics
30:2524–2526
13. Timo Glatter T, Christina Ludwig C, Ahrne ´ E
et al (2012) Large-scale quantitative assessment of different in-solution protein digestion
protocols reveals superior cleavage efficiency of
tandem Lys-C/trypsin proteolysis over trypsin
digestion. J Proteome Res 11:5145–5156
112
Kyle S. Feldman et al.