48
X. Feng et al.
Table 2.12 Hydrogenation of pyridines 32
entry substrate
product
yield (%) dr (%)
1
32a
N
Ph
Ph
33a
N
H
Ph
Ph
98
98/2
2
32b
N
O
O
33b
N
H
O
O
93
90/10
3
32c
N
F
OMe
33c
N
H
F
OMe
92
99/1
4
32d
N
Me
Ph
33d
N
H
Me
Ph
96
95/5
5
32e
N
Me
MeO
33e
N
H
Me
MeO
99
97/3
6
32f
N
OMe
33f
N
H
OMe
96
94/6
7
32g
N
Me
Me
33g
N
Me
Me
Ph
O
51
-8
32h
N
Br
Me
33h
N
Me
Ph
O
68
-9
32i
N
N
Me
Me
33i
NH N
Me
Me
59
96/4
10
32j
N
N
p-Tol
p-Tol
33j
NH HN
p-Tol
p-Tol
75
>99/1
11
32k
N
Me
C 11 H 23
33k
N
H
Me
C 11 H 23
60
93/7