36
X. Feng et al.
Table 2.3 Catalytic asymmetric hydrogenation of imines and enamines
(S)-13 (2.5-10 mol %)
imine
or
enamine
amine
H 2 (2 bar)
methyl tert-butyl ether
or toluene
Entry product
yield (%) ee (%)
1
5i
Ph
Me
HN
Bn
80
83
2
5j
Ph
Me
HN
Me
92
75
3
5k
Me
HN
Bn
79
34
4
5l
Bn
Me
HN
Me
72
32
5
5m
Ph
Me
HN
OMe
34
36
6
5n
N
95
99
7
5o
Me
Ph
N
81
95
8
5p
Me
N
42
85