prepare dynamically cross-linked cellulose-based hydrogels with dynamic stimuliresponse or self-healing behaviors.
For future outlook, more explorations should be focused on (1) “green” (safe
solvents, none, or nontoxic cross-linkers), solvent systems for cellulose and
low-energy processing for hydrogel preparation; (2) injectable cellulose-based
hydrogels forming by physical cross-links within the body for applications of
targeting drug release or tissue engineering; (3) pH- or enzymatic-sensitive cellulose-based gel by dynamic cross-links for drug release; (4) high-strength hydrogel
reinforced from nanocellulose for tissue replacement; (5) self-healable cellulosebased gel to prolong the lifetime and improve the durability; (6) development of
multifunctional integrated hydrogel on the basis of the structure and property of
cellulose as an economical way to improve efficacy, selectivity, or recycling during
water purification; (7) design of cellulose composite hydrogels with dynamic crosslinks and dissipation properties in a sacrificial manner; and (8) development of
cellulose to prepare novel hydrogels with unique characteristics such as photonic
properties. Undoubtedly, hydrogels based on cellulose and their derivatives still
offer abundant promising opportunities in various fields, although significant challenges would need to be overcome before commercialization, and thus fundamental
research into the nature of these systems should also continue.
References
1. Lee KY, Mooney DJ (2001) Chem Rev 101:1869–1880
2. Du X, Zhou J, Shi J, Xu B (2015) Chem Rev 115:13165–13307
3. Mogoşanu GD, Grumezescu AM (2014) Int J Pharm 463:127–136
4. Ahmed EM (2015) J Adv Res 6:105–121
5. Nagahama K, Ouchi T, Ohya Y (2008) Adv Funct Mater 18:1220–1231
6. Tomatsu I, Hashidzume A, Harada A (2006) J Am Chem Soc 128:2226–2227
7. Gao D, Xu H, Philbert MA, Kopelman R (2007) Angew Chem Int Ed 46:2224–2227
8. Martens PJ, Bryant SJ, Anseth KS (2003) Biomacromolecules 4:283–292
9. Nayak S, Lee H, Chmielewski J, Lyon LA (2004) J Am Chem Soc 126:10258–10259
10. Kim J, Singh N, Lyon LA (2006) Angew Chem Int Ed 45:1446–1449
11. Chang C, Zhang L (2011) Carbohydr Polym 84:40–53
12. Qiu Y, Park K (2001) Adv Drug Deliv Rev 53:321–339
13. Jayakumar R, Prabaharan M, Kumar PS, Nair S, Tamura H (2011) Biotechnol Adv
29:322–337
14. Zohuriaan-Mehr M, Pourjavadi A, Salimi H, Kurdtabar M (2009) Polym Adv Technol
20:655–671
15. Arbona V, Iglesias DJ, Jacas J, Primo-Millo E, Talon M, Gómez-Cadenas A (2005) Plant Soil
270:73–82
16. Kulkarni AR, Soppimath KS, Aminabhavi TM, Dave AM, Mehta MH (2000) J Control
Release 63:97–105
17. Juang R-S, Shiau R-C (2000) J Membr Sci 165:159–167
18. Paulino AT, Guilherme MR, Reis AV, Campese GM, Muniz EC, Nozaki J (2006) J Colloid
Interface Sci 301:55–62
19. Li G, Du Y, Tao Y, Deng H, Luo X, Yang J (2010) Carbohydr Polym 82:706–713
20. Dwivedi C, Gupta A, Chaudhary A, Nandi CK (2014) RSC Adv 4:39830–39838
Dynamics in Cellulose-Based Hydrogels with Reversible Cross-Links
349
For future outlook, more explorations should be focused on (1) “green” (safe
solvents, none, or nontoxic cross-linkers), solvent systems for cellulose and
low-energy processing for hydrogel preparation; (2) injectable cellulose-based
hydrogels forming by physical cross-links within the body for applications of
targeting drug release or tissue engineering; (3) pH- or enzymatic-sensitive cellulose-based gel by dynamic cross-links for drug release; (4) high-strength hydrogel
reinforced from nanocellulose for tissue replacement; (5) self-healable cellulosebased gel to prolong the lifetime and improve the durability; (6) development of
multifunctional integrated hydrogel on the basis of the structure and property of
cellulose as an economical way to improve efficacy, selectivity, or recycling during
water purification; (7) design of cellulose composite hydrogels with dynamic crosslinks and dissipation properties in a sacrificial manner; and (8) development of
cellulose to prepare novel hydrogels with unique characteristics such as photonic
properties. Undoubtedly, hydrogels based on cellulose and their derivatives still
offer abundant promising opportunities in various fields, although significant challenges would need to be overcome before commercialization, and thus fundamental
research into the nature of these systems should also continue.
References
1. Lee KY, Mooney DJ (2001) Chem Rev 101:1869–1880
2. Du X, Zhou J, Shi J, Xu B (2015) Chem Rev 115:13165–13307
3. Mogoşanu GD, Grumezescu AM (2014) Int J Pharm 463:127–136
4. Ahmed EM (2015) J Adv Res 6:105–121
5. Nagahama K, Ouchi T, Ohya Y (2008) Adv Funct Mater 18:1220–1231
6. Tomatsu I, Hashidzume A, Harada A (2006) J Am Chem Soc 128:2226–2227
7. Gao D, Xu H, Philbert MA, Kopelman R (2007) Angew Chem Int Ed 46:2224–2227
8. Martens PJ, Bryant SJ, Anseth KS (2003) Biomacromolecules 4:283–292
9. Nayak S, Lee H, Chmielewski J, Lyon LA (2004) J Am Chem Soc 126:10258–10259
10. Kim J, Singh N, Lyon LA (2006) Angew Chem Int Ed 45:1446–1449
11. Chang C, Zhang L (2011) Carbohydr Polym 84:40–53
12. Qiu Y, Park K (2001) Adv Drug Deliv Rev 53:321–339
13. Jayakumar R, Prabaharan M, Kumar PS, Nair S, Tamura H (2011) Biotechnol Adv
29:322–337
14. Zohuriaan-Mehr M, Pourjavadi A, Salimi H, Kurdtabar M (2009) Polym Adv Technol
20:655–671
15. Arbona V, Iglesias DJ, Jacas J, Primo-Millo E, Talon M, Gómez-Cadenas A (2005) Plant Soil
270:73–82
16. Kulkarni AR, Soppimath KS, Aminabhavi TM, Dave AM, Mehta MH (2000) J Control
Release 63:97–105
17. Juang R-S, Shiau R-C (2000) J Membr Sci 165:159–167
18. Paulino AT, Guilherme MR, Reis AV, Campese GM, Muniz EC, Nozaki J (2006) J Colloid
Interface Sci 301:55–62
19. Li G, Du Y, Tao Y, Deng H, Luo X, Yang J (2010) Carbohydr Polym 82:706–713
20. Dwivedi C, Gupta A, Chaudhary A, Nandi CK (2014) RSC Adv 4:39830–39838
Dynamics in Cellulose-Based Hydrogels with Reversible Cross-Links
349