Current Status of the Development of Blood-Based …
195
129. Fawcett, D.W., Vallee, B.L., Soule, M.H.: A method for concentration and segregation of
malignant cells from bloody, pleural, and peritoneal fluids. Science 111(2872), 34–36 (1950)
130. Seal, S.H.: Silicone flotation: a simple quantitative method for the isolation of free-floating
cancer cells from the blood. Cancer 12(3), 590–595 (1959)
131. Johnson, G.R.: The use of discontinuous percoll gradients to separate populations of cells
from human bone marrow and peripheral blood. J. Immunol. Methods 66(1), 9–16 (1984)
132. Lim, L.S., Hu, M., Huang, M.C., Cheong, W.C., Gan, A.T., Looi, X.L., Leong, S.M., Koay,
E.S., Li, M.H.: Microsieve lab-chip device for rapid enumeration and fluorescence in situ
hybridization of circulating tumor cells. Lab Chip 12(21), 4388–4396 (2012)
133. Adams, D.L., Zhu, P., Makarova, O.V., Martin, S.S., Charpentier, M., Chumsri, S., Li, S.,
Amstutz, P., Tang, C.M.: The systematic study of circulating tumor cell isolation using
lithographic microfilters. RSC Adv. 4(9), 4334–4342 (2014)
134. Kim, E.H., Lee, J.K., Kim, B.C., Rhim, S.H., Kim, J.W., Kim, K.H., Jung, S.M., Park,
P.S., Park, H.C., Lee, J., Jeon, B.H.: Enrichment of cancer cells from whole blood using
a microfabricated porous filter. Anal. Biochem. 440(1), 114–116 (2013)
135. Kim, T.H., Lim, M., Park, J., Oh, J.M., Kim, H., Jeong, H., Lee, S.J., Park, H.C., Jung, S.,
Kim, B.C., Lee, K.: FAST: size-selective, clog-free isolation of rare cancer cells from whole
blood at a liquid–liquid interface. Anal. Chem. 89(2), 1155–1162 (2016)
136. Coumans, F.A., van Dalum, G., Beck, M., Terstappen, L.W.: Filter characteristics influencing
circulating tumor cell enrichment from whole blood. PLoS One 8(4), e61770 (2013)
137. Zhou, M.D., Hao, S., Williams, A.J., Harouaka, R.A., Schrand, B., Rawal, S., Ao, Z., Brenneman, R., Gilboa, E., Lu, B., Wang, S.: Separable bilayer microfiltration device for viable
label-free enrichment of circulating tumour cells. Sci. Rep. 4(7392), 1–10 (2014)
138. Chung, J., Shao, H., Reiner, T., Issadore, D., Weissleder, R., Lee, H.: Microfluidic cell sorter
(FCS) for on-chip capture and analysis of single cells. Adv. Healthc. Mater. 4, 432–436 (2012)
139. Hvichia, G.E., Parveen, Z., Wagner, C., Janning, M., Quidde, J., Stein, A., Müller, V.,
Loges, S., Neves, R.P., Stoecklein, N.H., Wikman, H.: A novel microfluidic platform for
size and deformability based separation and the subsequent molecular characterization of
viable circulating tumor cells. Int. J. Cancer 138(12), 2894–2904 (2016)
140. Xu, L., Mao, X., Imrali, A., Syed, F., Mutsvangwa, K., Berney, D., Cathcart, P., Hines, J.,
Shamash, J., Lu, Y.J.: Optimization and evaluation of a novel size based circulating tumor
cell isolation system. PLoS One 10(9), e0138032 (2015)
141. Loutherback, K., D’Silva, J., Liu, L., Wu, A., Austin, R.H., Sturm, J.C.: Deterministic
separation of cancer cells from blood at 10 mL/min, AIP Adv. 2(4), 1–7
142. Hou, H.W., Warkiani, M.E., Khoo, B.L., Li, Z.R., Soo, R.A., Tan, D.S., Lim, W.T., Han, J.,
Bhagat, A.A., Lim, C.T.: Isolation and retrieval of circulating tumor cells using centrifugal
forces. Sci. Rep. 3, 1259 (2013)
143. Warkiani, M.E., Guan, G., Luan, K.B., Lee, W.C., Bhagat, A.A., Chaudhuri, P.K., Tan, D.S.,
Lim, W.T., Lee, S.C., Chen, P.C., Lim, C.T.: Slanted spiral microfluidics for the ultra-fast,
label-free isolation of circulating tumor cells. Lab Chip 14(1), 128–137 (2014)
144. Geislinger, T.M., Franke, T.: Sorting of circulating tumor cells (MV3-melanoma) and red
blood cells using non-inertial lift. Biomicrofluidics 7(4), 1–9 (2013)
145. Augustsson, P., Magnusson, C., Nordin, M., Lilja, H., Laurell, T.: Microfluidic, label-free
enrichment of prostate cancer cells in blood based on acoustophoresis. Anal. Chem. 84(18),
7954–7962 (2012)
146. Fabbri, F., Carloni, S., Zoli, W., Ulivi, P., Gallerani, G., Fici, P., Chiadini, E., Passardi, A.,
Frassineti, G.L., Ragazzini, A., Amadori, D.: Detection and recovery of circulating colon
cancer cells using a dielectrophoresis-based device: KRAS mutation status in pure CTCs.
Cancer Lett. 335(1), 225–231 (2013)
147. Moon, H.S., Kwon, K., Kime, S.I., Han, H., Sohn, J., Lee, S., Jung, H.I.: Continuous separation
of breast cancer cells from blood samples using multi-orifice flow fractionation (MOFF) and
dielectrophoresis (DEP). Lab Chip 11(6), 1118–1125 (2011)
148. Huang, C., Liu, H., Bander, N.H., Kirby, B.J.: Enrichment of prostate cancer cells from
blood cells with a hybrid dielectrophoresis and immunocapture microfluidic system. Biomed.
Microdevice 15(6), 941–948 (2013)
195
129. Fawcett, D.W., Vallee, B.L., Soule, M.H.: A method for concentration and segregation of
malignant cells from bloody, pleural, and peritoneal fluids. Science 111(2872), 34–36 (1950)
130. Seal, S.H.: Silicone flotation: a simple quantitative method for the isolation of free-floating
cancer cells from the blood. Cancer 12(3), 590–595 (1959)
131. Johnson, G.R.: The use of discontinuous percoll gradients to separate populations of cells
from human bone marrow and peripheral blood. J. Immunol. Methods 66(1), 9–16 (1984)
132. Lim, L.S., Hu, M., Huang, M.C., Cheong, W.C., Gan, A.T., Looi, X.L., Leong, S.M., Koay,
E.S., Li, M.H.: Microsieve lab-chip device for rapid enumeration and fluorescence in situ
hybridization of circulating tumor cells. Lab Chip 12(21), 4388–4396 (2012)
133. Adams, D.L., Zhu, P., Makarova, O.V., Martin, S.S., Charpentier, M., Chumsri, S., Li, S.,
Amstutz, P., Tang, C.M.: The systematic study of circulating tumor cell isolation using
lithographic microfilters. RSC Adv. 4(9), 4334–4342 (2014)
134. Kim, E.H., Lee, J.K., Kim, B.C., Rhim, S.H., Kim, J.W., Kim, K.H., Jung, S.M., Park,
P.S., Park, H.C., Lee, J., Jeon, B.H.: Enrichment of cancer cells from whole blood using
a microfabricated porous filter. Anal. Biochem. 440(1), 114–116 (2013)
135. Kim, T.H., Lim, M., Park, J., Oh, J.M., Kim, H., Jeong, H., Lee, S.J., Park, H.C., Jung, S.,
Kim, B.C., Lee, K.: FAST: size-selective, clog-free isolation of rare cancer cells from whole
blood at a liquid–liquid interface. Anal. Chem. 89(2), 1155–1162 (2016)
136. Coumans, F.A., van Dalum, G., Beck, M., Terstappen, L.W.: Filter characteristics influencing
circulating tumor cell enrichment from whole blood. PLoS One 8(4), e61770 (2013)
137. Zhou, M.D., Hao, S., Williams, A.J., Harouaka, R.A., Schrand, B., Rawal, S., Ao, Z., Brenneman, R., Gilboa, E., Lu, B., Wang, S.: Separable bilayer microfiltration device for viable
label-free enrichment of circulating tumour cells. Sci. Rep. 4(7392), 1–10 (2014)
138. Chung, J., Shao, H., Reiner, T., Issadore, D., Weissleder, R., Lee, H.: Microfluidic cell sorter
(FCS) for on-chip capture and analysis of single cells. Adv. Healthc. Mater. 4, 432–436 (2012)
139. Hvichia, G.E., Parveen, Z., Wagner, C., Janning, M., Quidde, J., Stein, A., Müller, V.,
Loges, S., Neves, R.P., Stoecklein, N.H., Wikman, H.: A novel microfluidic platform for
size and deformability based separation and the subsequent molecular characterization of
viable circulating tumor cells. Int. J. Cancer 138(12), 2894–2904 (2016)
140. Xu, L., Mao, X., Imrali, A., Syed, F., Mutsvangwa, K., Berney, D., Cathcart, P., Hines, J.,
Shamash, J., Lu, Y.J.: Optimization and evaluation of a novel size based circulating tumor
cell isolation system. PLoS One 10(9), e0138032 (2015)
141. Loutherback, K., D’Silva, J., Liu, L., Wu, A., Austin, R.H., Sturm, J.C.: Deterministic
separation of cancer cells from blood at 10 mL/min, AIP Adv. 2(4), 1–7
142. Hou, H.W., Warkiani, M.E., Khoo, B.L., Li, Z.R., Soo, R.A., Tan, D.S., Lim, W.T., Han, J.,
Bhagat, A.A., Lim, C.T.: Isolation and retrieval of circulating tumor cells using centrifugal
forces. Sci. Rep. 3, 1259 (2013)
143. Warkiani, M.E., Guan, G., Luan, K.B., Lee, W.C., Bhagat, A.A., Chaudhuri, P.K., Tan, D.S.,
Lim, W.T., Lee, S.C., Chen, P.C., Lim, C.T.: Slanted spiral microfluidics for the ultra-fast,
label-free isolation of circulating tumor cells. Lab Chip 14(1), 128–137 (2014)
144. Geislinger, T.M., Franke, T.: Sorting of circulating tumor cells (MV3-melanoma) and red
blood cells using non-inertial lift. Biomicrofluidics 7(4), 1–9 (2013)
145. Augustsson, P., Magnusson, C., Nordin, M., Lilja, H., Laurell, T.: Microfluidic, label-free
enrichment of prostate cancer cells in blood based on acoustophoresis. Anal. Chem. 84(18),
7954–7962 (2012)
146. Fabbri, F., Carloni, S., Zoli, W., Ulivi, P., Gallerani, G., Fici, P., Chiadini, E., Passardi, A.,
Frassineti, G.L., Ragazzini, A., Amadori, D.: Detection and recovery of circulating colon
cancer cells using a dielectrophoresis-based device: KRAS mutation status in pure CTCs.
Cancer Lett. 335(1), 225–231 (2013)
147. Moon, H.S., Kwon, K., Kime, S.I., Han, H., Sohn, J., Lee, S., Jung, H.I.: Continuous separation
of breast cancer cells from blood samples using multi-orifice flow fractionation (MOFF) and
dielectrophoresis (DEP). Lab Chip 11(6), 1118–1125 (2011)
148. Huang, C., Liu, H., Bander, N.H., Kirby, B.J.: Enrichment of prostate cancer cells from
blood cells with a hybrid dielectrophoresis and immunocapture microfluidic system. Biomed.
Microdevice 15(6), 941–948 (2013)