490
K. Tanaka
Table 23.11 Enantioselective Friedel–Crafts reactions of indole with N-sulfonyl aldimines
HO 2 C
CO 2 H
CO 2 H
HO 2 C
O
O
P
O
OH
(R)11
N
H
+
N
R 1
N
H
HN
R 1
R 2
R 2
(R)-MOF-11
r.t., 48h
Entry
R 1
R 2
Yield (%)
Ee (%)
1
Bs
H
39
42
2
Bs
H
38
39
3
Ts
H
32
44
4
T s
B r
4 2
4 0
5
T s
C l
4 5
2 9
Fig. 23.4 X-ray structure of (R)-MOF-12
K. Tanaka
Table 23.11 Enantioselective Friedel–Crafts reactions of indole with N-sulfonyl aldimines
HO 2 C
CO 2 H
CO 2 H
HO 2 C
O
O
P
O
OH
(R)11
N
H
+
N
R 1
N
H
HN
R 1
R 2
R 2
(R)-MOF-11
r.t., 48h
Entry
R 1
R 2
Yield (%)
Ee (%)
1
Bs
H
39
42
2
Bs
H
38
39
3
Ts
H
32
44
4
T s
B r
4 2
4 0
5
T s
C l
4 5
2 9
Fig. 23.4 X-ray structure of (R)-MOF-12