484
K. Tanaka
Table 23.4 (continued)
Entry
R 1
R 2
Yield (%)
Ee (%)
1
C l
H
9 9
98
2
C l
F
9 5
99
3
Cl
OMe
80
97
4
H
F
9 7
99
5
H
OMe
96
97
6
OMe
H
98
99
7
OMe
F
99
>99
Table 23.5 Cyanosilylation of aldehydes in the presence of (S)-MOF-6
N
V
O
N
O
t-Bu
t-Bu
CO 2 H
HO 2 C
O
(S)6
+
TMSCN
Ar-CHO
O
CN
Ar
TMS
(S)(S)-MOF-6
0
Entry
Ar
Yield (%)
Ee (%)
1
Ph
93
92 (S)
2
4-BrC 6 H 4
94
92 (S)
3
4-MeC 6 H 4
90
92 (S)
4
3-MeOC 6 H 4
92
95 (S)
5
4-MeOC 6 H 4
90
94 (S)
6
1-Naphthyl
91
92 (R)
7
2-Naphthyl
90
95 (S)
8
2-Thiophenyl
92
92 (S)
9
9-Anthryl
62
35 (S)
10
9-Anthryl
20
90 (S)
K. Tanaka
Table 23.4 (continued)
Entry
R 1
R 2
Yield (%)
Ee (%)
1
C l
H
9 9
98
2
C l
F
9 5
99
3
Cl
OMe
80
97
4
H
F
9 7
99
5
H
OMe
96
97
6
OMe
H
98
99
7
OMe
F
99
>99
Table 23.5 Cyanosilylation of aldehydes in the presence of (S)-MOF-6
N
V
O
N
O
t-Bu
t-Bu
CO 2 H
HO 2 C
O
(S)6
+
TMSCN
Ar-CHO
O
CN
Ar
TMS
(S)(S)-MOF-6
0
Entry
Ar
Yield (%)
Ee (%)
1
Ph
93
92 (S)
2
4-BrC 6 H 4
94
92 (S)
3
4-MeC 6 H 4
90
92 (S)
4
3-MeOC 6 H 4
92
95 (S)
5
4-MeOC 6 H 4
90
94 (S)
6
1-Naphthyl
91
92 (R)
7
2-Naphthyl
90
95 (S)
8
2-Thiophenyl
92
92 (S)
9
9-Anthryl
62
35 (S)
10
9-Anthryl
20
90 (S)