Table 5
(continued)
Compound
Chemical class
Target
Development
stage
Sponsor/coordinator
SQ109
Ethylenediamine
MmpL3
Phase 2
Sequella, Inc.
Auranofin
Gold-containing thiosugar
and triethyl phosphine
Thioredoxin reductase: trxB2
Phase 2
The Aurum Institute NPC, Calibr, The Scripps
Research Institute
Nitazoxanide
Synthetic
nitrothiazolyl-salicylamide
derivative
–
Phase 2
Weill Medical College of Cornell University
Bedaquiline
Diarlyquinoline
ATP Synthase
Phase 3
Janssen Research & Development, LLC
Delamanid
Nitrodihydro-imidazo
oxazole
Mycolic acid synthesis
Phase 3
Otsuka Pharmaceutical Development &
Commercialization
Rifamycin
(priftin)
RpoB Bacterial RNA
polymerase
Phase 3
CDC TBTC, Sanofi
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