DHO
Dihydroorotate
DHODH
Dihydroorotate dehydrogenase
dTMP
Deoxyribose thymidine monophosphate
E. coli.
Escherichia coli
FAD
Flavin adenine dinucleotide
FMN
Flavin mononucleotide
G/PLS
Genetic partial least squares
GAT/CPS Glutamine amidotransferase/carbamoyl phosphate synthetase
metaMM/GBSA Molecular mechanics/Generalized Born surface area
MSA
Molecular shape analysis
MLR
Multilinear regression
NAD
Nicotinamide adenine dinucleotide
OMPDC
Orotidine 5′-monophosphate decarboxylase
OPRT
Orotate phosphoribosyltransferase
ORO
Orotate
paraPb
Plasmodium berghei
PDB
Protein Data Bank
Pf
Plasmodium falciparum
PRPP
Phosphoribosylpyrophosphate
QSAR
Quantitative structure–activity relationship
RMS
Root mean square
RNA
Ribonucleic Acid
SBDD
Structure-based drug design
SVM
Support vector machine
UMP
Uridine monophosphate
UTP
Uridine triphosphate
1 Introduction
Malaria is one of the most challenging communicable diseases caused by plasmodium parasite. It affects half of the world’s population with 91 countries under
the direct risk of transmission. Five million more cases of malaria were reported
globally in 2016 compared to 2015. Children under the age of five are most susceptible to the disease with high death rate. The disease has a tropical and subtropical localization with prevalence in poor countries [1]. Due to the above facts
and figures, it becomes essential to look into measures to limit the spread of disease
and provide better solutions for curing malaria.
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S. Bhagat et al.