76
F. Cheng
Keywords Cardio-oncology · Cardiotoxicity · Drug-target network · Disease
module · Human protein-protein interactome · Network proximity · Systems
pharmacology
Abbreviations
ABL1
Abelson murine leukemia viral oncogene homolog 1
AP-MS
Affinity purification followed by mass spectrometry
ATC
Anatomical therapeutic chemical
BCR
Breakpoint cluster region protein
CM
Cardiomyopathy
CTD
The comparative toxicogenomics database
CV
Cardiovascular
CVD
Cardiovascular disease
ERBB2
Erb-b2 receptor tyrosine kinase 2
FDA
Food and drug administration
FGFR
Fibroblast growth factor receptor
GWAS
Genome-wide association studies
HER2
Human epidermal growth factor receptor 2
KIT
KIT proto-oncogene receptor tyrosine kinase
MeSH
Medical Subject Headings
MoA
Mechanism-of-action
NCBI
National Center for Biotechnology Information
OMIM
Online Mendelian Inheritance in Man
PDGFR
Platelet-derived growth factor receptor
PDGFRA Platelet-derived growth factor receptor A
PDGFRB Beta-type platelet-derived growth factor receptor
PheWAS Phenome-wide association study
PPI
Protein-protein interaction
QSP
Quantitative and systems pharmacology
SNP
Single-nucleotide polymorphisms
SRC
Proto-oncogene tyrosine-protein kinase Src
TTD
Therapeutic Target Database
UMLS
Unified Medical Language System
VEGFR Vascular endothelial growth factor receptor
Y2H
Yeast two-hybrid