384
B. Hardy et al.
open knowledge community approach supported within OpenTox and OpenRiskNet.
The general principle discussed in this article can be applied in regulatory settings.
Keywords In silico · Toxicology · Regulatory · Reproducibility · Data · Trust
and provenance · Blockchain
Abbreviations
AI
Artificial intelligence
AOP
Adverse outcome pathway
API
Application programming interface
DILI
Drug-induced liver injury
EMA
European Medicines Agency
FAIR
Findable, accessible, interoperable, and reusable
FDA
Food and Drug Administration
GDPR
General Data Protection Regulation
GPR
Global Patient Registration
IATA
Integrated Approach to Testing and Assessment
IPFS
InterPlanetary File System
IST
In Silico toxicology
ITS
Integrated testing strategy
IUCLID International Uniform ChemicaL Information Database
NDA
New Drug Application
OECD Organisation for Economic Co-operation and Development
OHT
OECD Harmonised Template
OS
Operating System
QMRF QSAR Model Reporting Format
QSAR
Quantitative Structure Activity Relationship
REACH Registration, Evaluation, Authorisation and Restriction of Chemicals
URL
Uniform Resource Locator
WoE
Weight of Evidence
XML
eXtensible Markup Language
19.1 Introduction
Reproducibility in science has raised significant concerns in recent years. For example, a recent study of 1500 scientists highlighted key issues with the finding: “More
than 70% of researchers have tried and failed to reproduce another scientist’s experiments, and more than half have failed to reproduce their own experiments.” http://
www.nature.com/news/1-500-scientists-lift-the-lid-on-reproducibility-1.19970.
B. Hardy et al.
open knowledge community approach supported within OpenTox and OpenRiskNet.
The general principle discussed in this article can be applied in regulatory settings.
Keywords In silico · Toxicology · Regulatory · Reproducibility · Data · Trust
and provenance · Blockchain
Abbreviations
AI
Artificial intelligence
AOP
Adverse outcome pathway
API
Application programming interface
DILI
Drug-induced liver injury
EMA
European Medicines Agency
FAIR
Findable, accessible, interoperable, and reusable
FDA
Food and Drug Administration
GDPR
General Data Protection Regulation
GPR
Global Patient Registration
IATA
Integrated Approach to Testing and Assessment
IPFS
InterPlanetary File System
IST
In Silico toxicology
ITS
Integrated testing strategy
IUCLID International Uniform ChemicaL Information Database
NDA
New Drug Application
OECD Organisation for Economic Co-operation and Development
OHT
OECD Harmonised Template
OS
Operating System
QMRF QSAR Model Reporting Format
QSAR
Quantitative Structure Activity Relationship
REACH Registration, Evaluation, Authorisation and Restriction of Chemicals
URL
Uniform Resource Locator
WoE
Weight of Evidence
XML
eXtensible Markup Language
19.1 Introduction
Reproducibility in science has raised significant concerns in recent years. For example, a recent study of 1500 scientists highlighted key issues with the finding: “More
than 70% of researchers have tried and failed to reproduce another scientist’s experiments, and more than half have failed to reproduce their own experiments.” http://
www.nature.com/news/1-500-scientists-lift-the-lid-on-reproducibility-1.19970.