282
R. Huang
Table 14.1 Tox21 assay 10K library screens
Assay
Assay name
PubChem AID
Reproducibility score
Stress response pathway assays
ATAD5
ATAD5
651632, 720516,
651634
99.51
DT40 Rad54/Ku70
DNA repair
Rad54/Ku70 deficient
isogenic chicken
DT40 cell viability
70743015
90.61
DT40 Rev3
DNA repair Rev3
deficient isogenic
chicken DT40 cell
viability
743014
83.02
DT40 WT
Wild type chicken
DT40 cell viability
743015
79.58
H2AX
H2AX
1224845, 1224847
93.71
P53
P53
651631, 720552,
651633
103.02
AP-1-BLA
Activator protein-1
1159526, 1159525,
1159528
91.65
ARE
Antioxidant
responsive element
743202, 743219,
743203
81.85
HRE-BLA agonist
Hypoxia-inducible
factor-1
1224846, 1224844
96.96
HSE-BLA
Heat shock factor
response element
743210, 743228,
743209
95.46
NFκB-BLA agonist
Nuclear factor kappa
B
1159509, 1159515,
1159518
100.31
ER stress
Endoplasmic
reticulum stress
1159516, 1159517,
1159519
92.97
Mitochondria toxicity Mitochondrial
toxicity
720635, 720637,
720634
87.20
Nuclear receptor assays
Aromatase
Aromatase
743083, 743139,
743084
93.66
AhR
Aryl hydrocarbon
receptor
743085, 743122,
743086
84.05
AR-BLA agonist
Androgen receptor,
ligand binding
domain, agonist
mode
743036, 743053
89.55
AR-BLA antagonist
Androgen receptor,
ligand binding
domain, antagonist
mode
743035, 743063,
743033
96.44
(continued)