13 Predicting the Risks of Drug-Induced Liver Injury …
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notypic traits, and synthetic biology-based bioengineering and biocontrol of invasive species. He
has advised more than 18 graduate students and published over 75 peer-reviewed research articles
and book chapters. He also served on the Board of Directors of MidSouth Computational Biology
and Bioinformatics Society (MCBIOS) as well as the editorial boards of Frontiers in Genetics and
Environmental Toxicology and Chemistry.
Chaoyang (Joe) Zhang is a professor in the School of Computing Sciences and Computer Engineering at the University of Southern Mississippi (USM). His research interests include data mining, machines learning, big data analytics and their applications to interdisciplinary areas of bioinformatics, health care, and toxicity analysis. His research has been supported by the National Science Foundation (NSF), Department of Defense (DOD), National Academy of Sciences (NAS),
and National Institute of Health (NIH). Dr. Zhang received his MS in computer science and Ph.D.
in computational analysis and modeling from Louisiana Tech University. Prior to joining USM in
2003, he was a research assistant professor in the Department of Computer Science at the University of Vermont.
Jürgen Borlak was born in Neu-Ulm, Germany in 1958. After studies at Universities in Germany and abroad, he obtained his Doctorate in Pharmacology and Toxicology at the University
of Reading, GB. Following residencies in the UK and France (Strasbourg), he was habilitated in
pharmacology and toxicology and received the venia legendi (“Privatdozent”) at Hannover Medical School in the year 2000. Two years later, he was appointed as a full professor of Pharmacology and Toxicology at Hannover Medical School. From 2002 onwards, he has been the Director
of the Institute of Pharmaco- and Toxicogenomics at Hannover Medical School. This new field
of genomic science applies a wide range of methods in genetics, molecular biology, molecular
toxicology, and functional genomics for a better understanding of disease-causing mechanisms
and drug-induced toxicities. An array of enabling technologies is applied for an identification of
“druggable” targets and for a better understanding of inter-individual differences in drug response,
therefore, allowing individualized drug treatment regimens and disease prevention strategies. Dr.
Borlak is author of >260 original publications and 25 book chapters and editor of the Handbook of
Toxicogenomics. He is reviewer and member of the editorial board for various scientific journals.
Among others, he is an appointed expert of the World Health Organization (WHO), the European
Medicines Agency (EMA), and the German regulatory agency (BfArM). He is also an international reviewer for many European, US, and Asian Research Organizations.
Huixiao Hong is the Chief of Bioinformatics Branch, Division of Bioinformatics and Biostatistics, National Center for Toxicological Research (NCTR), US Food and Drug Administration
(FDA), working on the scientific bases for regulatory applications of bioinformatics. Before joining the FDA, he was the Manager of Bioinformatics Division of Z-Tech, an ICFI company. He was
a research scientist position at Sumitomo Chemical Company in Japan and a visiting scientist at
National Cancer Institute at National Institutes of Health. He was also an Associate Professor and
the Director of Laboratory of Computational Chemistry at Nanjing University in China. Dr. Hong
is the member of steering committee of OpenTox, the member of board directors of US MidSouth
Computational Biology and Bioinformatics Society, and in the leadership circle of US FDA modeling and simulation working group. He published more than 180 scientific papers and served as
editor-in-chief and editorial board member for multiple peer-reviewed journals. He received his
Ph.D. from Nanjing University in China in 1990 and conducted research in Leeds University in
England in 1990–1992.
Weida Tong is Director of Division of Bioinformatics and Biostatistics at FDA’s National Center for Toxicological Research (NCTR/FDA). He has served as a science advisory board member for several large projects involving multiple institutes in Europe and the USA. He also holds
several adjunct positions at universities in the USA and China. His division at FDA works to
develop bioinformatic methodologies and standards to support FDA research and regulation and to
277
notypic traits, and synthetic biology-based bioengineering and biocontrol of invasive species. He
has advised more than 18 graduate students and published over 75 peer-reviewed research articles
and book chapters. He also served on the Board of Directors of MidSouth Computational Biology
and Bioinformatics Society (MCBIOS) as well as the editorial boards of Frontiers in Genetics and
Environmental Toxicology and Chemistry.
Chaoyang (Joe) Zhang is a professor in the School of Computing Sciences and Computer Engineering at the University of Southern Mississippi (USM). His research interests include data mining, machines learning, big data analytics and their applications to interdisciplinary areas of bioinformatics, health care, and toxicity analysis. His research has been supported by the National Science Foundation (NSF), Department of Defense (DOD), National Academy of Sciences (NAS),
and National Institute of Health (NIH). Dr. Zhang received his MS in computer science and Ph.D.
in computational analysis and modeling from Louisiana Tech University. Prior to joining USM in
2003, he was a research assistant professor in the Department of Computer Science at the University of Vermont.
Jürgen Borlak was born in Neu-Ulm, Germany in 1958. After studies at Universities in Germany and abroad, he obtained his Doctorate in Pharmacology and Toxicology at the University
of Reading, GB. Following residencies in the UK and France (Strasbourg), he was habilitated in
pharmacology and toxicology and received the venia legendi (“Privatdozent”) at Hannover Medical School in the year 2000. Two years later, he was appointed as a full professor of Pharmacology and Toxicology at Hannover Medical School. From 2002 onwards, he has been the Director
of the Institute of Pharmaco- and Toxicogenomics at Hannover Medical School. This new field
of genomic science applies a wide range of methods in genetics, molecular biology, molecular
toxicology, and functional genomics for a better understanding of disease-causing mechanisms
and drug-induced toxicities. An array of enabling technologies is applied for an identification of
“druggable” targets and for a better understanding of inter-individual differences in drug response,
therefore, allowing individualized drug treatment regimens and disease prevention strategies. Dr.
Borlak is author of >260 original publications and 25 book chapters and editor of the Handbook of
Toxicogenomics. He is reviewer and member of the editorial board for various scientific journals.
Among others, he is an appointed expert of the World Health Organization (WHO), the European
Medicines Agency (EMA), and the German regulatory agency (BfArM). He is also an international reviewer for many European, US, and Asian Research Organizations.
Huixiao Hong is the Chief of Bioinformatics Branch, Division of Bioinformatics and Biostatistics, National Center for Toxicological Research (NCTR), US Food and Drug Administration
(FDA), working on the scientific bases for regulatory applications of bioinformatics. Before joining the FDA, he was the Manager of Bioinformatics Division of Z-Tech, an ICFI company. He was
a research scientist position at Sumitomo Chemical Company in Japan and a visiting scientist at
National Cancer Institute at National Institutes of Health. He was also an Associate Professor and
the Director of Laboratory of Computational Chemistry at Nanjing University in China. Dr. Hong
is the member of steering committee of OpenTox, the member of board directors of US MidSouth
Computational Biology and Bioinformatics Society, and in the leadership circle of US FDA modeling and simulation working group. He published more than 180 scientific papers and served as
editor-in-chief and editorial board member for multiple peer-reviewed journals. He received his
Ph.D. from Nanjing University in China in 1990 and conducted research in Leeds University in
England in 1990–1992.
Weida Tong is Director of Division of Bioinformatics and Biostatistics at FDA’s National Center for Toxicological Research (NCTR/FDA). He has served as a science advisory board member for several large projects involving multiple institutes in Europe and the USA. He also holds
several adjunct positions at universities in the USA and China. His division at FDA works to
develop bioinformatic methodologies and standards to support FDA research and regulation and to