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88. Coordinators NR (2016) Database resources of the National Center for Biotechnology Information. Nucleic Acids Res 44(D1):D7–D19
89. Moslehi JJ (2016) Cardiovascular toxic effects of targeted cancer therapies. N Engl J Med
375(15):1457–1467
90. Schmidinger M, Zielinski CC, Vogl UM, Bojic A, Bojic M, Schukro C et al (2008) Cardiac
toxicity of sunitinib and sorafenib in patients with metastatic renal cell carcinoma. J Clin
Oncol 26(32):5204–5212
91. Ghofrani HA, Seeger W, Grimminger F (2005) Imatinib for the treatment of pulmonary arterial
hypertension. N Engl J Med 353(13):1412–1413
92. Ghofrani HA, Morrell NW, Hoeper MM, Olschewski H, Peacock AJ, Barst RJ et al (2010)
Imatinib in pulmonary arterial hypertension patients with inadequate response to established
therapy. Am J Respir Crit Care Med 182(9):1171–1177
93. Farha S, Dweik R, Rahaghi F, Benza R, Hassoun P, Frantz R et al (2014) Imatinib in pulmonary
arterial hypertension, c-Kit inhibition. Pulm Circ 4(3):452–455
94. Schermuly RT, Dony E, Ghofrani HA, Pullamsetti S, Savai R, Roth M et al (2005) Reversal of
experimental pulmonary hypertension by PDGF inhibition. J Clin Invest 115(10):2811–2821
95. Stumpf MP, Thorne T, de Silva E, Stewart R, An HJ, Lappe M et al (2008) Estimating the
size of the human interactome. Proc Natl Acad Sci USA 105(19):6959–6964
96. Gao J, Barzel B, Barabasi AL (2016) Universal resilience patterns in complex networks.
Nature 530(7590):307–312
97. Vinayagam A, Gibson TE, Lee HJ, Yilmazel B, Roesel C, Hu Y et al (2016) Controllability
analysis of the directed human protein interaction network identifies disease genes and drug
targets. Proc Natl Acad Sci USA 113(18):4976–4981
98. Bento AP, Gaulton A, Hersey A, Bellis LJ, Chambers J, Davies M et al (2014) The ChEMBL
bioactivity database, an update. Nucleic Acids Res 42(Database issue):D1083–1090
99. Gilson MK, Liu T, Baitaluk M, Nicola G, Hwang L, Chong J (2016) BindingDB in 2015, a
public database for medicinal chemistry, computational chemistry and systems pharmacology.
Nucleic Acids Res 44(D1):D1045–D1053
100. Wang Y, Bolton E, Dracheva S, Karapetyan K, Shoemaker BA, Suzek TO et al (2010)
An overview of the PubChem BioAssay resource. Nucleic Acids Res 38(Database
issue):D255–266
101. Wagner AH, Coffman AC, Ainscough BJ, Spies NC, Skidmore ZL, Campbell KM et al
(2016) DGIdb 2.0, mining clinically relevant drug-gene interactions. Nucleic Acids Res
44(D1):D1036–1044
102. Kuhn M, Szklarczyk D, Pletscher-Frankild S, Blicher TH, von Mering C, Jensen LJ et al
(2014) STITCH 4, integration of protein-chemical interactions with user data. Nucleic Acids
Res 42(Database issue):D401–407
103. Nickel J, Gohlke BO, Erehman J, Banerjee P, Rong WW, Goede A et al (2014) SuperPred, update on drug classification and target prediction. Nucleic Acids Res 42(Web Server
issue):W26–31
104. Lamb J (2007) The connectivity map, a new tool for biomedical research. Nat Rev Cancer
7(1):54–60
105. Duan Q, Flynn C, Niepel M, Hafner M, Muhlich JL, Fernandez NF et al (2014) LINCS Canvas
Browser, interactive web app to query, browse and interrogate LINCS L1000 gene expression
signatures. Nucleic Acids Res 42(Web Server issue):W449–460
106. Igarashi Y, Nakatsu N, Yamashita T, Ono A, Ohno Y, Urushidani T et al (2015)
Open TG-GATEs, a large-scale toxicogenomics database. Nucleic Acids Res 43(Database
issue):D921–927
107. Ganter B, Snyder RD, Halbert DN, Lee MD (2006) Toxicogenomics in drug discovery and
development, mechanistic analysis of compound/class-dependent effects using the DrugMatrix database. Pharmacogenomics 7(7):1025–1044
108. Keshava Prasad TS, Goel R, Kandasamy K, Keerthikumar S, Kumar S, Mathivanan S et al
(2009) Human protein reference database–2009 update. Nucleic Acids Res 37(Database
issue):D767–772
F. Cheng
88. Coordinators NR (2016) Database resources of the National Center for Biotechnology Information. Nucleic Acids Res 44(D1):D7–D19
89. Moslehi JJ (2016) Cardiovascular toxic effects of targeted cancer therapies. N Engl J Med
375(15):1457–1467
90. Schmidinger M, Zielinski CC, Vogl UM, Bojic A, Bojic M, Schukro C et al (2008) Cardiac
toxicity of sunitinib and sorafenib in patients with metastatic renal cell carcinoma. J Clin
Oncol 26(32):5204–5212
91. Ghofrani HA, Seeger W, Grimminger F (2005) Imatinib for the treatment of pulmonary arterial
hypertension. N Engl J Med 353(13):1412–1413
92. Ghofrani HA, Morrell NW, Hoeper MM, Olschewski H, Peacock AJ, Barst RJ et al (2010)
Imatinib in pulmonary arterial hypertension patients with inadequate response to established
therapy. Am J Respir Crit Care Med 182(9):1171–1177
93. Farha S, Dweik R, Rahaghi F, Benza R, Hassoun P, Frantz R et al (2014) Imatinib in pulmonary
arterial hypertension, c-Kit inhibition. Pulm Circ 4(3):452–455
94. Schermuly RT, Dony E, Ghofrani HA, Pullamsetti S, Savai R, Roth M et al (2005) Reversal of
experimental pulmonary hypertension by PDGF inhibition. J Clin Invest 115(10):2811–2821
95. Stumpf MP, Thorne T, de Silva E, Stewart R, An HJ, Lappe M et al (2008) Estimating the
size of the human interactome. Proc Natl Acad Sci USA 105(19):6959–6964
96. Gao J, Barzel B, Barabasi AL (2016) Universal resilience patterns in complex networks.
Nature 530(7590):307–312
97. Vinayagam A, Gibson TE, Lee HJ, Yilmazel B, Roesel C, Hu Y et al (2016) Controllability
analysis of the directed human protein interaction network identifies disease genes and drug
targets. Proc Natl Acad Sci USA 113(18):4976–4981
98. Bento AP, Gaulton A, Hersey A, Bellis LJ, Chambers J, Davies M et al (2014) The ChEMBL
bioactivity database, an update. Nucleic Acids Res 42(Database issue):D1083–1090
99. Gilson MK, Liu T, Baitaluk M, Nicola G, Hwang L, Chong J (2016) BindingDB in 2015, a
public database for medicinal chemistry, computational chemistry and systems pharmacology.
Nucleic Acids Res 44(D1):D1045–D1053
100. Wang Y, Bolton E, Dracheva S, Karapetyan K, Shoemaker BA, Suzek TO et al (2010)
An overview of the PubChem BioAssay resource. Nucleic Acids Res 38(Database
issue):D255–266
101. Wagner AH, Coffman AC, Ainscough BJ, Spies NC, Skidmore ZL, Campbell KM et al
(2016) DGIdb 2.0, mining clinically relevant drug-gene interactions. Nucleic Acids Res
44(D1):D1036–1044
102. Kuhn M, Szklarczyk D, Pletscher-Frankild S, Blicher TH, von Mering C, Jensen LJ et al
(2014) STITCH 4, integration of protein-chemical interactions with user data. Nucleic Acids
Res 42(Database issue):D401–407
103. Nickel J, Gohlke BO, Erehman J, Banerjee P, Rong WW, Goede A et al (2014) SuperPred, update on drug classification and target prediction. Nucleic Acids Res 42(Web Server
issue):W26–31
104. Lamb J (2007) The connectivity map, a new tool for biomedical research. Nat Rev Cancer
7(1):54–60
105. Duan Q, Flynn C, Niepel M, Hafner M, Muhlich JL, Fernandez NF et al (2014) LINCS Canvas
Browser, interactive web app to query, browse and interrogate LINCS L1000 gene expression
signatures. Nucleic Acids Res 42(Web Server issue):W449–460
106. Igarashi Y, Nakatsu N, Yamashita T, Ono A, Ohno Y, Urushidani T et al (2015)
Open TG-GATEs, a large-scale toxicogenomics database. Nucleic Acids Res 43(Database
issue):D921–927
107. Ganter B, Snyder RD, Halbert DN, Lee MD (2006) Toxicogenomics in drug discovery and
development, mechanistic analysis of compound/class-dependent effects using the DrugMatrix database. Pharmacogenomics 7(7):1025–1044
108. Keshava Prasad TS, Goel R, Kandasamy K, Keerthikumar S, Kumar S, Mathivanan S et al
(2009) Human protein reference database–2009 update. Nucleic Acids Res 37(Database
issue):D767–772