3. European Commission Nutrition and health
claims.
https://ec.europa.eu/food/safety/
labelling_nutrition/claims_en. In: .
4. USDA/HHS commitment to evidence-based
process.
http://www.nel.gov/default.cfm?
library¼DGAC.
5. Bohn T, McDougall G, Alegrı ´a A, Alminger M,
Arrigoni E, Aura A, Brito C, Cilla A, El SN,
Karakaya S, Martı ´nez-Cuesta MC, Santos CN
(2015) Mind the gap-deficits in our knowledge
of aspects impacting the bioavailability of phytochemicals and their metabolites—a position
paper focusing on carotenoids and polyphenols. Mol Nutr Food Res 59:1307–1323
6. Granado F, Olmedilla B, Herrero C, Pe ´rezSacrista ´n B, Blanco I, Bla ´zquez S (2006) Bioavailability of carotenoids and tocopherols
from broccoli: in vivo and in vitro assessment.
Exp Biol Med 231(11):1733–1738
7. Granado-Lorencio F, Olmedilla-Alonso B,
Herrero-Barbudo C, Pe ´rez-Sacrista ´n B,
Blanco-Navarro I, Bla ´zquez-Garcı ´a S (2007)
Comparative in vitro bioaccesibility of carotenoids from relevant contributors to carotenoid
intake. J Agric Food Chem 55(15):6387–6394
8. Rodrı ´guez-Concepcio ´ n M, Avalos J, Bonet
ML, Boronat A, Gomez-Gomez L, HorneroMendez D, Limon MC, Mele ´ndez-Martı ´nez
AJ, Olmedilla-Alonso B, Palou A, Ribot J,
Rodrigo MJ, Zacarias L, Zhu C (2018) A
global perspective on carotenoids: metabolism,
biotechnology, and benefits for nutrition and
health. Prog Lipid Res 70:62–93
9. Sheftel J, Loechl C, Mokhtar N, Tanumihardjo
SA (2018) Use of stable isotopes to evaluate
bioefficacy of provitamin a carotenoids, vitamin
a status, and bioavailability of iron and zinc.
Adv Nutr 9:625–636
10. USDA Food Composition Databases. United
States Department of Agriculture Agricultural
Research Service. https://ndb.nal.usda.gov/
ndb/nutrients/index.
11. Dias MG, Olmedilla-Alonso B, HorneroMe ´ndez D, Mercadante AZ, Osorio C,
Vargas-Murga L, Mele ´ndez-Martı ´nez AJ
(2018) Comprehensive database of carotenoid
contents in ibero-american foods. A valuable
tool in the context of functional foods and the
establishment of recommended intakes of
bioactives. J Agric Food Chem 66:5055–5107
12. WMA (World Medical Association) (2013)
Declaration of Helsinki—Ethical principles for
medical research involving human subjects. .
declaration-of-helsinki-ethical-principles-formedical-research-involving-human-subjects/
13. Council of Europe Convention on Human
Rights and Biomedicine. https://www.coe.
int/el/web/portal/full-news/-/asset_pub
lisher/Dgh51iCGvfbg/content/the-conven
tion-on-human-rights-and-biomedicinecelebrates-its-20th-anniversary.
14. UNESCO’s Universal Declaration on the
Human Genome and Human Rights. http://
sciences/themes/bioethics/human-genomeand-human-rights/.
15. Regulation 2016/679 of the European Parliament and of the Council of 27 April 2016.
https://eur-lex.europa.eu/legal-content/
EN/TXT/?uri¼celex%3A32016R0679.
16. Council of Europe (2016) Recommendation
CM/Rec(2016)6 of the Committee of Ministers to member States on research on biological
materials of human origin. . https://search.coe.
int/cm/Pages/result_details.aspx?
ObjectId¼090000168064e8ff
17. Aggett P, Antonine JM, de Vries J,
Gallagher A, Hendriks H, Kozianowski G,
Meijer G, Richardson D, Rondeau V,
Tweedie G, Welch R, Wittwer J (2010) Beyond
PASSCLAIM—Guidance
to
substantiate
health claims on foods. In Ates K (ed). ILSI
Eur Report Series, 7–19
18. Welch RW, Antonine JM, Berta JL, Bub A, De
VJ, Guarner F, Hasselwander FF, J€ akel M,
Koletzko BV, Patterson CC, Richelle M,
Skarp M, Theis S, Vidry S, Wodside JV
(2011) Guidelines for the design, conduct
and reporting of human intervention studies
to evaluate the health benefits of foods. Br J
Nutr 106(2):S3–S15
19. Lucey A, Heneghan C, Kiely ME (2016) Guidance for the design and implementation of
human dietary intervention studies for health
claim submissions. Nutr Bull 41:378–394
20. USDA-NIH (2018). https://www.nia.nih.
gov/research/grants-funding/implementa
tion-policies-human-intervention-studies.
21. CONSORT (Consolidated Standards of
Reporting Trials). www.consort-statement.org
22. Deeks JJ, Dinnes J, D’Amico R, Sowden AJ,
Sakarovitch C, Song F, Petticrew M, Altman
DG (2003) Evaluating non-randomised intervention studies. Health Technol Assesess 7(27)
23. Hawkes C (2004) Nutrition labels and health
claims: the global regulatory environment.
WHO
24. Combs GF, Trumbo PR, McKinley MC,
Milner J, Studenski S, Kimura T, Watkins SM,
Raiten DJ (2013) Biomarkers in nutrition: new
frontiers in research and application. Ann N Y
Acad Sci 1278:1–10
372
Begon ˜ a Olmedilla-Alonso
claims.
https://ec.europa.eu/food/safety/
labelling_nutrition/claims_en. In: .
4. USDA/HHS commitment to evidence-based
process.
http://www.nel.gov/default.cfm?
library¼DGAC.
5. Bohn T, McDougall G, Alegrı ´a A, Alminger M,
Arrigoni E, Aura A, Brito C, Cilla A, El SN,
Karakaya S, Martı ´nez-Cuesta MC, Santos CN
(2015) Mind the gap-deficits in our knowledge
of aspects impacting the bioavailability of phytochemicals and their metabolites—a position
paper focusing on carotenoids and polyphenols. Mol Nutr Food Res 59:1307–1323
6. Granado F, Olmedilla B, Herrero C, Pe ´rezSacrista ´n B, Blanco I, Bla ´zquez S (2006) Bioavailability of carotenoids and tocopherols
from broccoli: in vivo and in vitro assessment.
Exp Biol Med 231(11):1733–1738
7. Granado-Lorencio F, Olmedilla-Alonso B,
Herrero-Barbudo C, Pe ´rez-Sacrista ´n B,
Blanco-Navarro I, Bla ´zquez-Garcı ´a S (2007)
Comparative in vitro bioaccesibility of carotenoids from relevant contributors to carotenoid
intake. J Agric Food Chem 55(15):6387–6394
8. Rodrı ´guez-Concepcio ´ n M, Avalos J, Bonet
ML, Boronat A, Gomez-Gomez L, HorneroMendez D, Limon MC, Mele ´ndez-Martı ´nez
AJ, Olmedilla-Alonso B, Palou A, Ribot J,
Rodrigo MJ, Zacarias L, Zhu C (2018) A
global perspective on carotenoids: metabolism,
biotechnology, and benefits for nutrition and
health. Prog Lipid Res 70:62–93
9. Sheftel J, Loechl C, Mokhtar N, Tanumihardjo
SA (2018) Use of stable isotopes to evaluate
bioefficacy of provitamin a carotenoids, vitamin
a status, and bioavailability of iron and zinc.
Adv Nutr 9:625–636
10. USDA Food Composition Databases. United
States Department of Agriculture Agricultural
Research Service. https://ndb.nal.usda.gov/
ndb/nutrients/index.
11. Dias MG, Olmedilla-Alonso B, HorneroMe ´ndez D, Mercadante AZ, Osorio C,
Vargas-Murga L, Mele ´ndez-Martı ´nez AJ
(2018) Comprehensive database of carotenoid
contents in ibero-american foods. A valuable
tool in the context of functional foods and the
establishment of recommended intakes of
bioactives. J Agric Food Chem 66:5055–5107
12. WMA (World Medical Association) (2013)
Declaration of Helsinki—Ethical principles for
medical research involving human subjects. .
declaration-of-helsinki-ethical-principles-formedical-research-involving-human-subjects/
13. Council of Europe Convention on Human
Rights and Biomedicine. https://www.coe.
int/el/web/portal/full-news/-/asset_pub
lisher/Dgh51iCGvfbg/content/the-conven
tion-on-human-rights-and-biomedicinecelebrates-its-20th-anniversary.
14. UNESCO’s Universal Declaration on the
Human Genome and Human Rights. http://
sciences/themes/bioethics/human-genomeand-human-rights/.
15. Regulation 2016/679 of the European Parliament and of the Council of 27 April 2016.
https://eur-lex.europa.eu/legal-content/
EN/TXT/?uri¼celex%3A32016R0679.
16. Council of Europe (2016) Recommendation
CM/Rec(2016)6 of the Committee of Ministers to member States on research on biological
materials of human origin. . https://search.coe.
int/cm/Pages/result_details.aspx?
ObjectId¼090000168064e8ff
17. Aggett P, Antonine JM, de Vries J,
Gallagher A, Hendriks H, Kozianowski G,
Meijer G, Richardson D, Rondeau V,
Tweedie G, Welch R, Wittwer J (2010) Beyond
PASSCLAIM—Guidance
to
substantiate
health claims on foods. In Ates K (ed). ILSI
Eur Report Series, 7–19
18. Welch RW, Antonine JM, Berta JL, Bub A, De
VJ, Guarner F, Hasselwander FF, J€ akel M,
Koletzko BV, Patterson CC, Richelle M,
Skarp M, Theis S, Vidry S, Wodside JV
(2011) Guidelines for the design, conduct
and reporting of human intervention studies
to evaluate the health benefits of foods. Br J
Nutr 106(2):S3–S15
19. Lucey A, Heneghan C, Kiely ME (2016) Guidance for the design and implementation of
human dietary intervention studies for health
claim submissions. Nutr Bull 41:378–394
20. USDA-NIH (2018). https://www.nia.nih.
gov/research/grants-funding/implementa
tion-policies-human-intervention-studies.
21. CONSORT (Consolidated Standards of
Reporting Trials). www.consort-statement.org
22. Deeks JJ, Dinnes J, D’Amico R, Sowden AJ,
Sakarovitch C, Song F, Petticrew M, Altman
DG (2003) Evaluating non-randomised intervention studies. Health Technol Assesess 7(27)
23. Hawkes C (2004) Nutrition labels and health
claims: the global regulatory environment.
WHO
24. Combs GF, Trumbo PR, McKinley MC,
Milner J, Studenski S, Kimura T, Watkins SM,
Raiten DJ (2013) Biomarkers in nutrition: new
frontiers in research and application. Ann N Y
Acad Sci 1278:1–10
372
Begon ˜ a Olmedilla-Alonso