63:183–213.
https://doi.org/10.1146/
annurev-arplant-042811-105608
7. Kang J, Hwang JU, Lee M, Kim YY, Assmann
SM, Martinoia E, Lee Y (2010) PDR-type
ABC transporter mediates cellular uptake of
the phytohormone abscisic acid. Proc Natl
Acad Sci U S A 107(5):2355–2360. https://
doi.org/10.1073/pnas.0909222107
8. Kang J, Yim S, Choi H, Kim A, Lee KP, LopezMolina L, Martinoia E, Lee Y (2015) Abscisic
acid transporters cooperate to control seed germination. Nat Commun 6:8113. https://doi.
org/10.1038/ncomms9113
9. Kuromori T, Miyaji T, Yabuuchi H,
Shimizu H, Sugimoto E, Kamiya A,
Moriyama Y, Shinozaki K (2010) ABC transporter AtABCG25 is involved in abscisic acid
transport and responses. Proc Natl Acad Sci U
S A 107(5):2361–2366. https://doi.org/10.
1073/pnas.0912516107
10. Burla B, Pfrunder S, Nagy R, Francisco RM,
Lee Y, Martinoia E (2013) Vacuolar transport
of abscisic acid glucosyl ester is mediated by
ATP-binding cassette and proton-antiport
mechanisms in Arabidopsis. Plant Physiol 163
(3):1446–1458. https://doi.org/10.1104/
pp.113.222547
11. Kretzschmar T, Kohlen W, Sasse J, Borghi L,
Schlegel M, Bachelier JB, Reinhardt D,
Bours R, Bouwmeester HJ, Martinoia E
(2012) A petunia ABC protein controls
strigolactone-dependent symbiotic signalling
and branching. Nature 483(7389):341–344.
https://doi.org/10.1038/nature10873
12. Tejada-Jimenez M, Galvan A, Fernandez E
(2011) Algae and humans share a molybdate
transporter. Proc Natl Acad Sci U S A 108
(16):6420–6425. https://doi.org/10.1073/
pnas.1100700108
13. Larsen B, Xu D, Halkier BA, Nour-Eldin HH
(2017) Advances in methods for identification
and characterization of plant transporter function. J Exp Bot 68(15):4045–4056. https://
doi.org/10.1093/jxb/erx140
14. Miller AJ, Zhou JJ (2000) Xenopus oocytes as
an expression system for plant transporters.
Biochim Biophys Acta 1465(1–2):343–358
15. Ozvegy C, Litman T, Szakacs G, Nagy Z,
Bates S, Varadi A, Sarkadi B (2001) Functional
characterization of the human multidrug transporter, ABCG2, expressed in insect cells.
Biochem Biophys Res Commun 285
(1):111–117. https://doi.org/10.1006/bbrc.
2001.5130
16. Shoji T (2014) ATP-binding cassette and multidrug and toxic compound extrusion transporters in plants: a common theme among diverse
detoxification mechanisms. Int Rev Cell Mol
Biol
309:303–346.
https://doi.org/10.
1016/b978-0-12-800255-1.00006-5
17. Remy E, Duque P (2014) Beyond cellular
detoxification: a plethora of physiological
roles for MDR transporter homologs in plants.
Front Physiol 5:201. https://doi.org/10.
3389/fphys.2014.00201
18. Yazaki K (2006) ABC transporters involved in
the transport of plant secondary metabolites.
FEBS Lett 580(4):1183–1191. https://doi.
org/10.1016/j.febslet.2005.12.009
19. Krumpochova P, Sapthu S, Brouwers JF, de
Haas M, de Vos R, Borst P, van de Wetering
K (2012) Transportomics: screening for substrates of ABC transporters in body fluids using
vesicular transport assays. FASEB J 26
(2):738–747.
https://doi.org/10.1096/fj.
11-195743
20. Tommasini R, Evers R, Vogt E, Mornet C,
Zaman GJ, Schinkel AH, Borst P, Martinoia E
(1996) The human multidrug resistanceassociated protein functionally complements
the yeast cadmium resistance factor 1. Proc
Natl Acad Sci U S A 93(13):6743–6748
21. Bradford MM (1976) A rapid and sensitive
method for the quantitation of microgram
quantities of protein utilizing the principle of
protein-dye
binding.
Anal
Biochem
72:248–254
22. Paumi CM, Chuk M, Snider J, Stagljar I,
Michaelis S (2009) ABC transporters in Saccharomyces cerevisiae and their interactors:
new technology advances the biology of the
ABCC (MRP) subfamily. Microbiol Mol Biol
Rev 73(4):577–593. https://doi.org/10.
1128/mmbr.00020-09
23. Gomez C, Terrier N, Torregrosa L, Vialet S,
Fournier-Level A, Verries C, Souquet JM,
Mazauric JP, Klein M, Cheynier V, Ageorges
A (2009) Grapevine MATE-type proteins act as
vacuolar H+-dependent acylated anthocyanin
transporters. Plant Physiol 150(1):402–415.
https://doi.org/10.1104/pp.109.135624
Transportomics for Apocarotenoid Transporters
99
https://doi.org/10.1146/
annurev-arplant-042811-105608
7. Kang J, Hwang JU, Lee M, Kim YY, Assmann
SM, Martinoia E, Lee Y (2010) PDR-type
ABC transporter mediates cellular uptake of
the phytohormone abscisic acid. Proc Natl
Acad Sci U S A 107(5):2355–2360. https://
doi.org/10.1073/pnas.0909222107
8. Kang J, Yim S, Choi H, Kim A, Lee KP, LopezMolina L, Martinoia E, Lee Y (2015) Abscisic
acid transporters cooperate to control seed germination. Nat Commun 6:8113. https://doi.
org/10.1038/ncomms9113
9. Kuromori T, Miyaji T, Yabuuchi H,
Shimizu H, Sugimoto E, Kamiya A,
Moriyama Y, Shinozaki K (2010) ABC transporter AtABCG25 is involved in abscisic acid
transport and responses. Proc Natl Acad Sci U
S A 107(5):2361–2366. https://doi.org/10.
1073/pnas.0912516107
10. Burla B, Pfrunder S, Nagy R, Francisco RM,
Lee Y, Martinoia E (2013) Vacuolar transport
of abscisic acid glucosyl ester is mediated by
ATP-binding cassette and proton-antiport
mechanisms in Arabidopsis. Plant Physiol 163
(3):1446–1458. https://doi.org/10.1104/
pp.113.222547
11. Kretzschmar T, Kohlen W, Sasse J, Borghi L,
Schlegel M, Bachelier JB, Reinhardt D,
Bours R, Bouwmeester HJ, Martinoia E
(2012) A petunia ABC protein controls
strigolactone-dependent symbiotic signalling
and branching. Nature 483(7389):341–344.
https://doi.org/10.1038/nature10873
12. Tejada-Jimenez M, Galvan A, Fernandez E
(2011) Algae and humans share a molybdate
transporter. Proc Natl Acad Sci U S A 108
(16):6420–6425. https://doi.org/10.1073/
pnas.1100700108
13. Larsen B, Xu D, Halkier BA, Nour-Eldin HH
(2017) Advances in methods for identification
and characterization of plant transporter function. J Exp Bot 68(15):4045–4056. https://
doi.org/10.1093/jxb/erx140
14. Miller AJ, Zhou JJ (2000) Xenopus oocytes as
an expression system for plant transporters.
Biochim Biophys Acta 1465(1–2):343–358
15. Ozvegy C, Litman T, Szakacs G, Nagy Z,
Bates S, Varadi A, Sarkadi B (2001) Functional
characterization of the human multidrug transporter, ABCG2, expressed in insect cells.
Biochem Biophys Res Commun 285
(1):111–117. https://doi.org/10.1006/bbrc.
2001.5130
16. Shoji T (2014) ATP-binding cassette and multidrug and toxic compound extrusion transporters in plants: a common theme among diverse
detoxification mechanisms. Int Rev Cell Mol
Biol
309:303–346.
https://doi.org/10.
1016/b978-0-12-800255-1.00006-5
17. Remy E, Duque P (2014) Beyond cellular
detoxification: a plethora of physiological
roles for MDR transporter homologs in plants.
Front Physiol 5:201. https://doi.org/10.
3389/fphys.2014.00201
18. Yazaki K (2006) ABC transporters involved in
the transport of plant secondary metabolites.
FEBS Lett 580(4):1183–1191. https://doi.
org/10.1016/j.febslet.2005.12.009
19. Krumpochova P, Sapthu S, Brouwers JF, de
Haas M, de Vos R, Borst P, van de Wetering
K (2012) Transportomics: screening for substrates of ABC transporters in body fluids using
vesicular transport assays. FASEB J 26
(2):738–747.
https://doi.org/10.1096/fj.
11-195743
20. Tommasini R, Evers R, Vogt E, Mornet C,
Zaman GJ, Schinkel AH, Borst P, Martinoia E
(1996) The human multidrug resistanceassociated protein functionally complements
the yeast cadmium resistance factor 1. Proc
Natl Acad Sci U S A 93(13):6743–6748
21. Bradford MM (1976) A rapid and sensitive
method for the quantitation of microgram
quantities of protein utilizing the principle of
protein-dye
binding.
Anal
Biochem
72:248–254
22. Paumi CM, Chuk M, Snider J, Stagljar I,
Michaelis S (2009) ABC transporters in Saccharomyces cerevisiae and their interactors:
new technology advances the biology of the
ABCC (MRP) subfamily. Microbiol Mol Biol
Rev 73(4):577–593. https://doi.org/10.
1128/mmbr.00020-09
23. Gomez C, Terrier N, Torregrosa L, Vialet S,
Fournier-Level A, Verries C, Souquet JM,
Mazauric JP, Klein M, Cheynier V, Ageorges
A (2009) Grapevine MATE-type proteins act as
vacuolar H+-dependent acylated anthocyanin
transporters. Plant Physiol 150(1):402–415.
https://doi.org/10.1104/pp.109.135624
Transportomics for Apocarotenoid Transporters
99