1 3
Topics in Current Chemistry (2020) 378:40
270. Sosnovik DE, Weissleder R (2007) Emerging concepts in molecular MRI. Curr Opin Biotechnol
18(1):4–10. https ://doi.org/10.1016/j.copbi o.2006.11.001
271. Klausner RD (1996) The future of cancer research and the role of the National Cancer Institute. J
Clin Oncol 14(10):2878–2883. https ://doi.org/10.1200/JCO.1996.14.10.2878
272. Gillies RJ (2002) In vivo molecular imaging. J Cell Biochem 87(S39):231–238. https ://doi.
org/10.1002/jcb.10450
273. Reimer P, Weissleder R, Lee AS, Wittenberg J, Brady TJ (1990) Receptor imaging: application to MR imaging of liver cancer. Radiology 177(3):729–734. https ://doi.org/10.1148/radio
logy.177.3.22439 78
274. Tsoukalas C, Psimadas D, Kastis GA, Koutoulidis V, Harris AL, Paravatou-Petsotas M, Karageorgou M, Furenlid LR, Moulopoulos LA, Stamopoulos D, Bouziotis P (2018) A novel metalbased imaging probe for targeted dual-modality SPECT/MR imaging of angiogenesis. Front Chem
6:224–224. https ://doi.org/10.3389/fchem .2018.00224
275. Ding N, Sano K, Kanazaki K, Ohashi M, Deguchi J, Kanada Y, Ono M, Saji H (2016) In vivo
HER2-targeted magnetic resonance tumor imaging using iron oxide nanoparticles conjugated
with anti-HER2 fragment antibody. Mol Imag Biol 18(6):870–876. https ://doi.org/10.1007/s1130
7-016-0977-2
276. Ge Y, Zhong Y, Ji G, Lu Q, Dai X, Guo Z, Zhang P, Peng G, Zhang K, Li Y (2018) Preparation and characterization of Fe 3 O 4 @Au-C225 composite targeted nanoparticles for MRI of human
glioma. PLoS ONE 13(4):e0195703–e0195703. https ://doi.org/10.1371/journ al.pone.01957 03
277. Conde J, Bao C, Cui D, Baptista PV, Tian F (2014) Antibody–drug gold nanoantennas with Raman
spectroscopic fingerprints for in vivo tumour theranostics. J Control Release 183:87–93. https ://
doi.org/10.1016/j.jconr el.2014.03.045
278. Zarschler K, Prapainop K, Mahon E, Rocks L, Bramini M, Kelly PM, Stephan H, Dawson KA
(2014) Diagnostic nanoparticle targeting of the EGF-receptor in complex biological conditions
using single-domain antibodies. Nanoscale 6(11):6046–6056. https ://doi.org/10.1039/C4NR0
0595C
279. Shevtsov MA, Nikolaev BP, Yakovleva LY, Marchenko YY, Dobrodumov AV, Mikhrina AL, Martynova MG, Bystrova OA, Yakovenko IV, Ischenko AM (2014) Superparamagnetic iron oxide nanoparticles conjugated with epidermal growth factor (SPION-EGF) for targeting brain tumors. Int J
Nanomed 9:273–287. https ://doi.org/10.2147/IJN.S5511 8
280. Ren J, Zhang Z, Wang F, Yang Y, Liu Y, Wei G, Yang A, Zhang R, Huan Y, Cui Y, Larson AC
(2012) MRI of prostate stem cell antigen expression in prostate tumors. Nanomedicine 7(5):691–
703. https ://doi.org/10.2217/nnm.11.147
281. Gottschalk K-E, Kessler H (2002) The structures of integrins and integrin–ligand complexes:
implications for drug design and signal transduction. Angew Chem Int Ed 41(20):3767–3774. https
://doi.org/10.1002/1521-3773(20021 018)41:20%3c376 7:AID-ANIE3 767%3e3.0.CO;2-T
282. Akhtar MJ, Ahamed M, Alhadlaq HA, Alrokayan SA, Kumar S (2014) Targeted anticancer
therapy: overexpressed receptors and nanotechnology. Clin Chim Acta 436:78–92. https ://doi.
org/10.1016/j.cca.2014.05.004
283. Yameen B, Choi WI, Vilos C, Swami A, Shi J, Farokhzad OC (2014) Insight into nanoparticle cellular uptake and intracellular targeting. J Control Release 190:485–499. https ://doi.org/10.1016/j.
jconr el.2014.06.038
284. Chen K, Xie J, Xu H, Behera D, Michalski MH, Biswal S, Wang A, Chen X (2009) Triblock
copolymer coated iron oxide nanoparticle conjugate for tumor integrin targeting. Biomaterials
30(36):6912–6919. https ://doi.org/10.1016/j.bioma teria ls.2009.08.045
285. Chen L, Xie J, Wu H, Zang F, Ma M, Hua Z, Gu N, Zhang Y (2018) Improving sensitivity of magnetic resonance imaging by using a dual-targeted magnetic iron oxide nanoprobe. Colloids Surf B
Biointerfaces 161:339–346. https ://doi.org/10.1016/j.colsu rfb.2017.10.059
286. Sánchez A, Ovejero Paredes K, Ruiz-Cabello J, Martínez-Ruíz P, Pingarrón JM, Villalonga R,
Filice M (2018) Hybrid decorated core@shell janus nanoparticles as a flexible platform for targeted multimodal molecular bioimaging of cancer. ACS Appl Mater Interfaces 10(37):31032–
31043. https ://doi.org/10.1021/acsam i.8b104 52
287. Li J, Wu C, Hou P, Zhang M, Xu K (2018) One-pot preparation of hydrophilic manganese
oxide nanoparticles as T1 nano-contrast agent for molecular magnetic resonance imaging of
renal carcinoma in vitro and in vivo. Biosens Bioelectron 102:1–8. https ://doi.org/10.1016/j.
bios.2017.10.047
89
Reprinted from the journal
Topics in Current Chemistry (2020) 378:40
270. Sosnovik DE, Weissleder R (2007) Emerging concepts in molecular MRI. Curr Opin Biotechnol
18(1):4–10. https ://doi.org/10.1016/j.copbi o.2006.11.001
271. Klausner RD (1996) The future of cancer research and the role of the National Cancer Institute. J
Clin Oncol 14(10):2878–2883. https ://doi.org/10.1200/JCO.1996.14.10.2878
272. Gillies RJ (2002) In vivo molecular imaging. J Cell Biochem 87(S39):231–238. https ://doi.
org/10.1002/jcb.10450
273. Reimer P, Weissleder R, Lee AS, Wittenberg J, Brady TJ (1990) Receptor imaging: application to MR imaging of liver cancer. Radiology 177(3):729–734. https ://doi.org/10.1148/radio
logy.177.3.22439 78
274. Tsoukalas C, Psimadas D, Kastis GA, Koutoulidis V, Harris AL, Paravatou-Petsotas M, Karageorgou M, Furenlid LR, Moulopoulos LA, Stamopoulos D, Bouziotis P (2018) A novel metalbased imaging probe for targeted dual-modality SPECT/MR imaging of angiogenesis. Front Chem
6:224–224. https ://doi.org/10.3389/fchem .2018.00224
275. Ding N, Sano K, Kanazaki K, Ohashi M, Deguchi J, Kanada Y, Ono M, Saji H (2016) In vivo
HER2-targeted magnetic resonance tumor imaging using iron oxide nanoparticles conjugated
with anti-HER2 fragment antibody. Mol Imag Biol 18(6):870–876. https ://doi.org/10.1007/s1130
7-016-0977-2
276. Ge Y, Zhong Y, Ji G, Lu Q, Dai X, Guo Z, Zhang P, Peng G, Zhang K, Li Y (2018) Preparation and characterization of Fe 3 O 4 @Au-C225 composite targeted nanoparticles for MRI of human
glioma. PLoS ONE 13(4):e0195703–e0195703. https ://doi.org/10.1371/journ al.pone.01957 03
277. Conde J, Bao C, Cui D, Baptista PV, Tian F (2014) Antibody–drug gold nanoantennas with Raman
spectroscopic fingerprints for in vivo tumour theranostics. J Control Release 183:87–93. https ://
doi.org/10.1016/j.jconr el.2014.03.045
278. Zarschler K, Prapainop K, Mahon E, Rocks L, Bramini M, Kelly PM, Stephan H, Dawson KA
(2014) Diagnostic nanoparticle targeting of the EGF-receptor in complex biological conditions
using single-domain antibodies. Nanoscale 6(11):6046–6056. https ://doi.org/10.1039/C4NR0
0595C
279. Shevtsov MA, Nikolaev BP, Yakovleva LY, Marchenko YY, Dobrodumov AV, Mikhrina AL, Martynova MG, Bystrova OA, Yakovenko IV, Ischenko AM (2014) Superparamagnetic iron oxide nanoparticles conjugated with epidermal growth factor (SPION-EGF) for targeting brain tumors. Int J
Nanomed 9:273–287. https ://doi.org/10.2147/IJN.S5511 8
280. Ren J, Zhang Z, Wang F, Yang Y, Liu Y, Wei G, Yang A, Zhang R, Huan Y, Cui Y, Larson AC
(2012) MRI of prostate stem cell antigen expression in prostate tumors. Nanomedicine 7(5):691–
703. https ://doi.org/10.2217/nnm.11.147
281. Gottschalk K-E, Kessler H (2002) The structures of integrins and integrin–ligand complexes:
implications for drug design and signal transduction. Angew Chem Int Ed 41(20):3767–3774. https
://doi.org/10.1002/1521-3773(20021 018)41:20%3c376 7:AID-ANIE3 767%3e3.0.CO;2-T
282. Akhtar MJ, Ahamed M, Alhadlaq HA, Alrokayan SA, Kumar S (2014) Targeted anticancer
therapy: overexpressed receptors and nanotechnology. Clin Chim Acta 436:78–92. https ://doi.
org/10.1016/j.cca.2014.05.004
283. Yameen B, Choi WI, Vilos C, Swami A, Shi J, Farokhzad OC (2014) Insight into nanoparticle cellular uptake and intracellular targeting. J Control Release 190:485–499. https ://doi.org/10.1016/j.
jconr el.2014.06.038
284. Chen K, Xie J, Xu H, Behera D, Michalski MH, Biswal S, Wang A, Chen X (2009) Triblock
copolymer coated iron oxide nanoparticle conjugate for tumor integrin targeting. Biomaterials
30(36):6912–6919. https ://doi.org/10.1016/j.bioma teria ls.2009.08.045
285. Chen L, Xie J, Wu H, Zang F, Ma M, Hua Z, Gu N, Zhang Y (2018) Improving sensitivity of magnetic resonance imaging by using a dual-targeted magnetic iron oxide nanoprobe. Colloids Surf B
Biointerfaces 161:339–346. https ://doi.org/10.1016/j.colsu rfb.2017.10.059
286. Sánchez A, Ovejero Paredes K, Ruiz-Cabello J, Martínez-Ruíz P, Pingarrón JM, Villalonga R,
Filice M (2018) Hybrid decorated core@shell janus nanoparticles as a flexible platform for targeted multimodal molecular bioimaging of cancer. ACS Appl Mater Interfaces 10(37):31032–
31043. https ://doi.org/10.1021/acsam i.8b104 52
287. Li J, Wu C, Hou P, Zhang M, Xu K (2018) One-pot preparation of hydrophilic manganese
oxide nanoparticles as T1 nano-contrast agent for molecular magnetic resonance imaging of
renal carcinoma in vitro and in vivo. Biosens Bioelectron 102:1–8. https ://doi.org/10.1016/j.
bios.2017.10.047
89
Reprinted from the journal