Topics in Current Chemistry (2020) 378:28
1 3
even though there have been a few attempts to achieve bioimaging and biodetection
in vivo using TiO 2 -based nanomaterials, near-infrared PEC and ECL biosensing are
only rarely addressed in the literature and therefore require detailed investigation.
The detection or imaging of a single molecule, cell, or particle may be an important
area of research in the future. Third, in some situations, the function and mechanism
of the TiO 2 -based nanomaterial in the biosensing methods is still unclear and therefore requires further study that makes use of the advances that are currently being
made in nanotechnology and instrument characterization. In a word, for the foreseeable future, the use of rationally designed and modified TiO 2 nanomaterials in PEC
and ECL biosensors has the potential to substantially broaden the range of applications of these detection systems.
Acknowledgements Funding from the National Natural Science Foundation of China (nos. 21874126 and
21675148) and The National Key Research and Development Program of China (no. 2016YFA0201300)
are greatly appreciated.
References
1. Zhao W, Xu J, Chen H (2015) Photoelectrochemical bioanalysis: the state of the art. Chem Soc Rev
44(3):729–741. https ://doi.org/10.1039/C4CS0 0228H
2. Zang Y, Lei J, Ju H (2017) Principles and applications of photoelectrochemical sensing strategies
based on biofunctionalized nanostructures. Biosens Bioelectron 96:8–16. https ://doi.org/10.1016/j.
bios.2017.04.030
3. Shu J, Tang D (2019) Recent advances in photoelectrochemical sensing: from engineered photoactive materials to sensing devices and detection modes. Anal Chem. https ://doi.org/10.1021/acs.analc
hem.9b041 99
4. Liu Z, Qi W, Xu G (2015) Recent advances in electrochemiluminescence. Chem Soc Rev
44(10):3117–3142. https ://doi.org/10.1039/C5CS0 0086F
5. Gao W, Saqib M, Qi L, Zhang W, Xu G (2017) Recent advances in electrochemiluminescence
devices for point-of-care testing. Curr Opin Electrochem 3(1):4–10. https ://doi.org/10.1016/j.coele
c.2017.03.003
6. Chen Y, Zhou S, Li L, Zhu J (2017) Nanomaterials-based sensitive electrochemiluminescence biosensing. Nano Today 12:98–115. https ://doi.org/10.1016/j.nanto d.2016.12.013
7. Kumar N, Chauhan NS, Mittal A, Sharma S (2018) TiO 2 and its composites as promising biomaterials: a review. Biometals 31(2):147–159. https ://doi.org/10.1007/s1053 4-018-0078-6
8. Zang Y, Fan J, Ju Y, Xue H, Pang H (2018) Current advances in semiconductor nanomaterialbased photoelectrochemical biosensing. Chemistry 24(53):14010–14027. https ://doi.org/10.1002/
chem.20180 1358
9. Chen J, Kong L, Sun X, Feng J, Chen Z, Fan D, Wei Q (2018) Ultrasensitive photoelectrochemical
immunosensor of cardiac troponin I detection based on dual inhibition effect of Ag@Cu 2 O coreshell submicron-particles on CdS QDs sensitized TiO 2 nanosheets. Biosens Bioelectron 117:340–
346. https ://doi.org/10.1016/j.bios.2018.05.037
10. Pang X, Bian H, Wang W, Liu C, Khan MS, Wang Q, Qi J, Wei Q, Du B (2017) A bio-chemical
application of N-GQDs and g-C 3 N 4 QDs sensitized TiO 2 nanopillars for the quantitative detection
of pcDNA3-HBV. Biosens Bioelectron 91:456–464. https ://doi.org/10.1016/j.bios.2016.12.059
11. Yang L, Liu X, Li L, Zhang S, Zheng H, Tang Y, Ju H (2019) A visible light photoelectrochemical
sandwich aptasensor for adenosine triphosphate based on MgIn 2 S 4 –TiO 2 nanoarray heterojunction.
Biosens Bioelectron 142:111487. https ://doi.org/10.1016/j.bios.2019.11148 7
12. Shu J, Qiu Z, Zhuang J, Xu M, Tang D (2015) In situ generation of electron donor to assist signal
amplification on porphyrin-sensitized titanium dioxide nanostructures for ultrasensitive photoelectrochemical immunoassay. ACS Appl Mater Interfaces 7(42):23812–23818. https ://doi.org/10.1021/
acsam i.5b087 42
14
Reprinted from the journal
1 3
even though there have been a few attempts to achieve bioimaging and biodetection
in vivo using TiO 2 -based nanomaterials, near-infrared PEC and ECL biosensing are
only rarely addressed in the literature and therefore require detailed investigation.
The detection or imaging of a single molecule, cell, or particle may be an important
area of research in the future. Third, in some situations, the function and mechanism
of the TiO 2 -based nanomaterial in the biosensing methods is still unclear and therefore requires further study that makes use of the advances that are currently being
made in nanotechnology and instrument characterization. In a word, for the foreseeable future, the use of rationally designed and modified TiO 2 nanomaterials in PEC
and ECL biosensors has the potential to substantially broaden the range of applications of these detection systems.
Acknowledgements Funding from the National Natural Science Foundation of China (nos. 21874126 and
21675148) and The National Key Research and Development Program of China (no. 2016YFA0201300)
are greatly appreciated.
References
1. Zhao W, Xu J, Chen H (2015) Photoelectrochemical bioanalysis: the state of the art. Chem Soc Rev
44(3):729–741. https ://doi.org/10.1039/C4CS0 0228H
2. Zang Y, Lei J, Ju H (2017) Principles and applications of photoelectrochemical sensing strategies
based on biofunctionalized nanostructures. Biosens Bioelectron 96:8–16. https ://doi.org/10.1016/j.
bios.2017.04.030
3. Shu J, Tang D (2019) Recent advances in photoelectrochemical sensing: from engineered photoactive materials to sensing devices and detection modes. Anal Chem. https ://doi.org/10.1021/acs.analc
hem.9b041 99
4. Liu Z, Qi W, Xu G (2015) Recent advances in electrochemiluminescence. Chem Soc Rev
44(10):3117–3142. https ://doi.org/10.1039/C5CS0 0086F
5. Gao W, Saqib M, Qi L, Zhang W, Xu G (2017) Recent advances in electrochemiluminescence
devices for point-of-care testing. Curr Opin Electrochem 3(1):4–10. https ://doi.org/10.1016/j.coele
c.2017.03.003
6. Chen Y, Zhou S, Li L, Zhu J (2017) Nanomaterials-based sensitive electrochemiluminescence biosensing. Nano Today 12:98–115. https ://doi.org/10.1016/j.nanto d.2016.12.013
7. Kumar N, Chauhan NS, Mittal A, Sharma S (2018) TiO 2 and its composites as promising biomaterials: a review. Biometals 31(2):147–159. https ://doi.org/10.1007/s1053 4-018-0078-6
8. Zang Y, Fan J, Ju Y, Xue H, Pang H (2018) Current advances in semiconductor nanomaterialbased photoelectrochemical biosensing. Chemistry 24(53):14010–14027. https ://doi.org/10.1002/
chem.20180 1358
9. Chen J, Kong L, Sun X, Feng J, Chen Z, Fan D, Wei Q (2018) Ultrasensitive photoelectrochemical
immunosensor of cardiac troponin I detection based on dual inhibition effect of Ag@Cu 2 O coreshell submicron-particles on CdS QDs sensitized TiO 2 nanosheets. Biosens Bioelectron 117:340–
346. https ://doi.org/10.1016/j.bios.2018.05.037
10. Pang X, Bian H, Wang W, Liu C, Khan MS, Wang Q, Qi J, Wei Q, Du B (2017) A bio-chemical
application of N-GQDs and g-C 3 N 4 QDs sensitized TiO 2 nanopillars for the quantitative detection
of pcDNA3-HBV. Biosens Bioelectron 91:456–464. https ://doi.org/10.1016/j.bios.2016.12.059
11. Yang L, Liu X, Li L, Zhang S, Zheng H, Tang Y, Ju H (2019) A visible light photoelectrochemical
sandwich aptasensor for adenosine triphosphate based on MgIn 2 S 4 –TiO 2 nanoarray heterojunction.
Biosens Bioelectron 142:111487. https ://doi.org/10.1016/j.bios.2019.11148 7
12. Shu J, Qiu Z, Zhuang J, Xu M, Tang D (2015) In situ generation of electron donor to assist signal
amplification on porphyrin-sensitized titanium dioxide nanostructures for ultrasensitive photoelectrochemical immunoassay. ACS Appl Mater Interfaces 7(42):23812–23818. https ://doi.org/10.1021/
acsam i.5b087 42
14
Reprinted from the journal