1 3
Topics in Current Chemistry (2020) 378:8
second wave of research of directed synthesis and application of plasmonic NPs
under in vivo conditions.
Acknowledgements We apologize to authors whose work could not be included in this review due to
space restrictions. Support from the Ministry of Science, Innovation and Universities of Spain is acknowledged through the MANA project CTQ2017-83961-R and JEANS project CTQ2017-92264-EXP. J. J.
G.-C. acknowledges the Ministry of Science, Innovation and Universities of Spain for a “Ramon y Cajal”
contract (#RyC-2014-14956). M. C. thanks the “Plan Propio de Investigación” from the Universidad de
Córdoba (UCO) and the “Programa Operativo de fondos FEDER Andalucía” for its financial support
through both postdoctoral contracts (Modality 5.2.A).
References
1. Huang X, Jain PK, El-Sayed IH, El-Sayed MA (2007) Gold nanoparticles: interesting optical properties and recent applications in cancer diagnostics and therapy. Nanomedicine 2:681–693. https ://
doi.org/10.2217/17435 889.2.5.681
2. Giner-Casares JJ, Henriksen-Lacey M, Coronado-Puchau M, Liz-Marzán LM (2016) Inorganic nanoparticles for biomedicine: where materials scientists meet medical research. Mater Today 19:19–
28. https ://doi.org/10.1016/j.matto d.2015.07.004
3. Ogarev VA, Rudoi VM, Dement’eva OV (2018) Gold nanoparticles: synthesis, optical properties,
and application. Inorg Mater Appl Res 9:134–140. https ://doi.org/10.1134/S2075 11331 80101 97
4. Shukla R, Bansal V, Chaudhary M et al (2005) Biocompatibility of gold nanoparticles and their
endocytotic fate inside the cellular compartment: a microscopic overview. Langmuir 21:10644–
10654. https ://doi.org/10.1021/la051 3712
Table 1 Representative cargoes in through bioconjugated plasmonic nanoparticles (NPs) for skin disease
treatments
Active molecule
Cargo type
Activity/application
NP
References
Imatinib mesylate
Drug
Anticancer
Au
[66]
Methotrexate (MTX)
Drug
Anti-inflammatory (psoriasis) Au
[67, 78]
microRNA mir-221
Gene
Tumour suppressor (melanoma)
Au
[69]
Vascular endothelial growth
factor (VEGF)
Protein
Wound repair
Au
[70]
Ibuprofen
Drug
Anti-inflammatory
Au
[74]
Diltiazem hydrochloride
Drug
Vasodilator
Au
[75]
5-fluorouracil (5-FU)
Drug
Anticancer
Au
[71, 72]
Ruxolitinib
Drug
Anti-alopecia
Au
[73]
Keratinocyte growth factor
(KGF)
Protein
Wound repair
Au
[68]
Polyphenols-rich extracts
(Cornus mas)
Natural extract
Anti-inflammatory (psoriasis) Au & Ag [76]
Antimicrobial peptide LL-37
and pDNA: Pro-angiogenic
(VEGF) plasmids
Protein and gene Diabetic wound healing
Au
[77]
Calreticulin
Protein
Diabetic wound healing
Au
[79]
Curcumin
Natural extract
Anticancer
Ag
[80]
231
Reprinted from the journal
Topics in Current Chemistry (2020) 378:8
second wave of research of directed synthesis and application of plasmonic NPs
under in vivo conditions.
Acknowledgements We apologize to authors whose work could not be included in this review due to
space restrictions. Support from the Ministry of Science, Innovation and Universities of Spain is acknowledged through the MANA project CTQ2017-83961-R and JEANS project CTQ2017-92264-EXP. J. J.
G.-C. acknowledges the Ministry of Science, Innovation and Universities of Spain for a “Ramon y Cajal”
contract (#RyC-2014-14956). M. C. thanks the “Plan Propio de Investigación” from the Universidad de
Córdoba (UCO) and the “Programa Operativo de fondos FEDER Andalucía” for its financial support
through both postdoctoral contracts (Modality 5.2.A).
References
1. Huang X, Jain PK, El-Sayed IH, El-Sayed MA (2007) Gold nanoparticles: interesting optical properties and recent applications in cancer diagnostics and therapy. Nanomedicine 2:681–693. https ://
doi.org/10.2217/17435 889.2.5.681
2. Giner-Casares JJ, Henriksen-Lacey M, Coronado-Puchau M, Liz-Marzán LM (2016) Inorganic nanoparticles for biomedicine: where materials scientists meet medical research. Mater Today 19:19–
28. https ://doi.org/10.1016/j.matto d.2015.07.004
3. Ogarev VA, Rudoi VM, Dement’eva OV (2018) Gold nanoparticles: synthesis, optical properties,
and application. Inorg Mater Appl Res 9:134–140. https ://doi.org/10.1134/S2075 11331 80101 97
4. Shukla R, Bansal V, Chaudhary M et al (2005) Biocompatibility of gold nanoparticles and their
endocytotic fate inside the cellular compartment: a microscopic overview. Langmuir 21:10644–
10654. https ://doi.org/10.1021/la051 3712
Table 1 Representative cargoes in through bioconjugated plasmonic nanoparticles (NPs) for skin disease
treatments
Active molecule
Cargo type
Activity/application
NP
References
Imatinib mesylate
Drug
Anticancer
Au
[66]
Methotrexate (MTX)
Drug
Anti-inflammatory (psoriasis) Au
[67, 78]
microRNA mir-221
Gene
Tumour suppressor (melanoma)
Au
[69]
Vascular endothelial growth
factor (VEGF)
Protein
Wound repair
Au
[70]
Ibuprofen
Drug
Anti-inflammatory
Au
[74]
Diltiazem hydrochloride
Drug
Vasodilator
Au
[75]
5-fluorouracil (5-FU)
Drug
Anticancer
Au
[71, 72]
Ruxolitinib
Drug
Anti-alopecia
Au
[73]
Keratinocyte growth factor
(KGF)
Protein
Wound repair
Au
[68]
Polyphenols-rich extracts
(Cornus mas)
Natural extract
Anti-inflammatory (psoriasis) Au & Ag [76]
Antimicrobial peptide LL-37
and pDNA: Pro-angiogenic
(VEGF) plasmids
Protein and gene Diabetic wound healing
Au
[77]
Calreticulin
Protein
Diabetic wound healing
Au
[79]
Curcumin
Natural extract
Anticancer
Ag
[80]
231
Reprinted from the journal