Topics in Current Chemistry (2020) 378:35
1 3
Paper-based microfluidic systems have been revealed as the most suitable platform for POC analysis, with the use of QDs as labels becoming increasingly popular
in the development of this type of systems. Although fluorescence QD-based POC
systems using hand-held readers or even smartphone-based detectors have been successfully reported, they suffer from an important limitation related to the need for
bulky and complex detectors for quantification. However, it is expected that the use
of alternative detection methods (e.g. electrochemical) and the rapid development of
portable devices and mobile phone technology will allow the miniaturization of the
detection systems for POC devices in the near future. Miniaturized signal-recording devices also require a merging of QD barcode technology and POC testing. In
the sensing field, there is also a great expectation for recently developed GQDs and
CQDs.
To summarize, even though there is still a long road to go before bioconjugated
QDs are considered to be routine in in vitro and especially in vivo diagnosis, overall
we firmly believe that the rapid development of new bioconjugated nanomaterials
will move bioconjugated QDs forward to real-life diagnostic applications in modern
biology and medicine.
Acknowledgements Financial support from the FC-GRUPIN-ID/2018/000166 project (Asturias
Regional Government, Spain) and the CTQ2017–86994-R and CTQ2016–79412-P projects (MINECO,
Spain) is gratefully acknowledged. A. de la Escosura-Muñiz acknowledges the MICINN (Spain) for the
“Ramón y Cajal” Research Fellow (RyC-2016-20299).
References
1. Prado M, Espiña B, Fernández-Argüelles MT, Diéguez L, Fuciños P, Vial S, Oliveira JM, Reis RL,
Boehme K (2016) Detection of foodborne pathogens using nanoparticles. Advantages and trends.
In: Barros-Velázquez J (ed) Antimicrobial food packaging. Elsevier, Amsterdam, pp 183–201
2. Trapiella-Alfonso L, Llano-Suárez P, Sanz-Medel A, Costa-Fernández JM, Fernández-Argüelles
MT (2017) Analytical nanoscience and nanotechnology. In: Meyers RA (ed) Encyclopedia of analytical chemistry. Wiley, Hoboken, pp 1–24
3. Lopez-Lorente A, Valcarcel M (2016) The third way in analytical nanoscience and nanotechnology: involvement of nanotools and nanoanalytes in the same analytical process. Trends Anal Chem
75:1–9
4. Blanco-López MC, Rivas M (2019) Nanoparticles for bioanalysis. Anal Bioanal Chem
411:1789–1790
5. Ahsan MA, Jabbari V, Imam MA, Castro E, Kim H, Curry ML, Valles-Rosales DJ, Noveron JC
(2020) Nanoscale nickel metal organic framework decorated over graphene oxide and carbon nanotubes for water remediation. Sci Total Environ 698:134214
6. Cova CM, Zuliani A, Santiago ARP, Caballero A, Muñoz-Batista MJ, Luque R (2018) Microwaveassisted preparation of Ag/Ag 2 S carbon hybrid structures from pig bristles as efficient HER catalysts. J Mater Chem A 6:21516–21523
7. Ahsan MA, Deemer E, Fernandez-Delgado O, Wang H, Curry ML, El-Gendy AA, Noveron JC
(2019) Fe nanoparticles encapsulated in MOF-derived carbon for the reduction of 4-nitrophenol
and methyl orange in water. Catal Commun 130:105753
8. Ahsan MA, Jabbari V, El-Gendy AA, Curry ML, Noveron JC (2019) Ultrafast catalytic reduction
of environmental pollutants in water via MOF-derived magnetic Ni and Cu nanoparticles encapsulated in porous carbon. App Surf Sci 497:143608
9. Ahsan MA, Fernandez-Delgado O, Deemer E, Wang H, El-Gendy AA, Curry ML, Noveron JC
(2019) Carbonization of Co-BDC MOF results in magnetic C@Co nanoparticles that catalyze the
reduction of methyl orange and 4-nitrophenol in water. J Mol Liq 290:111059
168
Reprinted from the journal
1 3
Paper-based microfluidic systems have been revealed as the most suitable platform for POC analysis, with the use of QDs as labels becoming increasingly popular
in the development of this type of systems. Although fluorescence QD-based POC
systems using hand-held readers or even smartphone-based detectors have been successfully reported, they suffer from an important limitation related to the need for
bulky and complex detectors for quantification. However, it is expected that the use
of alternative detection methods (e.g. electrochemical) and the rapid development of
portable devices and mobile phone technology will allow the miniaturization of the
detection systems for POC devices in the near future. Miniaturized signal-recording devices also require a merging of QD barcode technology and POC testing. In
the sensing field, there is also a great expectation for recently developed GQDs and
CQDs.
To summarize, even though there is still a long road to go before bioconjugated
QDs are considered to be routine in in vitro and especially in vivo diagnosis, overall
we firmly believe that the rapid development of new bioconjugated nanomaterials
will move bioconjugated QDs forward to real-life diagnostic applications in modern
biology and medicine.
Acknowledgements Financial support from the FC-GRUPIN-ID/2018/000166 project (Asturias
Regional Government, Spain) and the CTQ2017–86994-R and CTQ2016–79412-P projects (MINECO,
Spain) is gratefully acknowledged. A. de la Escosura-Muñiz acknowledges the MICINN (Spain) for the
“Ramón y Cajal” Research Fellow (RyC-2016-20299).
References
1. Prado M, Espiña B, Fernández-Argüelles MT, Diéguez L, Fuciños P, Vial S, Oliveira JM, Reis RL,
Boehme K (2016) Detection of foodborne pathogens using nanoparticles. Advantages and trends.
In: Barros-Velázquez J (ed) Antimicrobial food packaging. Elsevier, Amsterdam, pp 183–201
2. Trapiella-Alfonso L, Llano-Suárez P, Sanz-Medel A, Costa-Fernández JM, Fernández-Argüelles
MT (2017) Analytical nanoscience and nanotechnology. In: Meyers RA (ed) Encyclopedia of analytical chemistry. Wiley, Hoboken, pp 1–24
3. Lopez-Lorente A, Valcarcel M (2016) The third way in analytical nanoscience and nanotechnology: involvement of nanotools and nanoanalytes in the same analytical process. Trends Anal Chem
75:1–9
4. Blanco-López MC, Rivas M (2019) Nanoparticles for bioanalysis. Anal Bioanal Chem
411:1789–1790
5. Ahsan MA, Jabbari V, Imam MA, Castro E, Kim H, Curry ML, Valles-Rosales DJ, Noveron JC
(2020) Nanoscale nickel metal organic framework decorated over graphene oxide and carbon nanotubes for water remediation. Sci Total Environ 698:134214
6. Cova CM, Zuliani A, Santiago ARP, Caballero A, Muñoz-Batista MJ, Luque R (2018) Microwaveassisted preparation of Ag/Ag 2 S carbon hybrid structures from pig bristles as efficient HER catalysts. J Mater Chem A 6:21516–21523
7. Ahsan MA, Deemer E, Fernandez-Delgado O, Wang H, Curry ML, El-Gendy AA, Noveron JC
(2019) Fe nanoparticles encapsulated in MOF-derived carbon for the reduction of 4-nitrophenol
and methyl orange in water. Catal Commun 130:105753
8. Ahsan MA, Jabbari V, El-Gendy AA, Curry ML, Noveron JC (2019) Ultrafast catalytic reduction
of environmental pollutants in water via MOF-derived magnetic Ni and Cu nanoparticles encapsulated in porous carbon. App Surf Sci 497:143608
9. Ahsan MA, Fernandez-Delgado O, Deemer E, Wang H, El-Gendy AA, Curry ML, Noveron JC
(2019) Carbonization of Co-BDC MOF results in magnetic C@Co nanoparticles that catalyze the
reduction of methyl orange and 4-nitrophenol in water. J Mol Liq 290:111059
168
Reprinted from the journal