5 Concluding Remarks
We hope that this chapter has provided a deeper insight into the methods and
practices that have been used to explore the solid-state forms of organic and
metal-organic materials under high-pressure conditions. We wanted to provide a
framework of practice that could be used as a reference text for those entering into
the area of high-pressure research. We have tried to provide a balanced view of the
science conducted in the areas of organic and metal-organic solid-state chemistry,
but inevitably there will be studies that have been overlooked due to the sheer
volume of data and articles in the literature; if we have missed a few, we can only
apologise. As you will have read, the area of high pressure on molecular materials is
vast even considering that there are many spectroscopic studies of materials at high
pressure that we have not discussed here in detail. The future for high-pressure
science on molecular systems is bright, and with advances of techniques, only the
imagination is the kinetic barrier to discovery in the twenty-first century and beyond.
References
1. Oswald IDH, Lennie AR, Pulham CR, Shankland K (2010) High-pressure structural studies of
the pharmaceutical, chlorothiazide. CrystEngComm 12:2533
2. Moggach SA, Parsons S, Wood PA (2008) High-pressure polymorphism in amino acids.
Crystallogr Rev 14:143–184
3. Fairen-Jimenez D, Moggach SA, Wharmby MT, Wright PA, Parsons S, Düren T (2011)
Opening the gate: framework flexibility in ZIF-8 explored by experiments and simulations. J
Am Chem Soc 133:8900–8902
4. Yoo CS, Cynn H (1999) Equation of state, phase transition, decomposition of β-HMX
(octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine) at high pressures. J Chem Phys
111:10229–10235
5. Millar DIA, Marshall WG, Oswald IDH, Pulham CR (2010) High-pressure structural studies
of energetic materials. Crystallogr Rev 16:115–132
6. Neumann MA, Van De Streek J, Fabbiani FPA, Hidber P, Grassmann O (2015) Combined
crystal structure prediction and high-pressure crystallization in rational pharmaceutical polymorph screening. Nat Commun 6:7793
7. Bhardwaj RM, McMahon JA, Nyman J, Price LS, Konar S, Oswald IDH, Pulham CR, Price
SL, Reutzel-Edens SM (2019) A prolific solvate former, galunisertib, under the pressure of
crystal structure prediction, produces ten diverse polymorphs. J Am Chem Soc
141:13887–13897
8. Boldyreva EV (2008) High-pressure diffraction studies of molecular organic solids. A personal view. Acta Crystallogr Sect A Found Crystallogr 64:218–231
9. Fabbiani FPA, Pulham CR (2006) High-pressure studies of pharmaceutical compounds and
energetic materials. Chem Soc Rev 35:932–942
10. Katrusiak A (2008) High-pressure crystallography. Acta Cryst 64:135–148
11. Miletich R, Allan DR, Kuhs WF (2000) High-pressure single-crystal techniques. Rev Mineral
Geochem 41:445–519
12. Sidorov NV, Krasyukov YN, Mukhtarova ÉI, Shkrabo DM (2000) Phase transition and
domain structure in iodoform crystals. Crystallogr Rep 45:288–293
Crystallography Under High Pressures
189
We hope that this chapter has provided a deeper insight into the methods and
practices that have been used to explore the solid-state forms of organic and
metal-organic materials under high-pressure conditions. We wanted to provide a
framework of practice that could be used as a reference text for those entering into
the area of high-pressure research. We have tried to provide a balanced view of the
science conducted in the areas of organic and metal-organic solid-state chemistry,
but inevitably there will be studies that have been overlooked due to the sheer
volume of data and articles in the literature; if we have missed a few, we can only
apologise. As you will have read, the area of high pressure on molecular materials is
vast even considering that there are many spectroscopic studies of materials at high
pressure that we have not discussed here in detail. The future for high-pressure
science on molecular systems is bright, and with advances of techniques, only the
imagination is the kinetic barrier to discovery in the twenty-first century and beyond.
References
1. Oswald IDH, Lennie AR, Pulham CR, Shankland K (2010) High-pressure structural studies of
the pharmaceutical, chlorothiazide. CrystEngComm 12:2533
2. Moggach SA, Parsons S, Wood PA (2008) High-pressure polymorphism in amino acids.
Crystallogr Rev 14:143–184
3. Fairen-Jimenez D, Moggach SA, Wharmby MT, Wright PA, Parsons S, Düren T (2011)
Opening the gate: framework flexibility in ZIF-8 explored by experiments and simulations. J
Am Chem Soc 133:8900–8902
4. Yoo CS, Cynn H (1999) Equation of state, phase transition, decomposition of β-HMX
(octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine) at high pressures. J Chem Phys
111:10229–10235
5. Millar DIA, Marshall WG, Oswald IDH, Pulham CR (2010) High-pressure structural studies
of energetic materials. Crystallogr Rev 16:115–132
6. Neumann MA, Van De Streek J, Fabbiani FPA, Hidber P, Grassmann O (2015) Combined
crystal structure prediction and high-pressure crystallization in rational pharmaceutical polymorph screening. Nat Commun 6:7793
7. Bhardwaj RM, McMahon JA, Nyman J, Price LS, Konar S, Oswald IDH, Pulham CR, Price
SL, Reutzel-Edens SM (2019) A prolific solvate former, galunisertib, under the pressure of
crystal structure prediction, produces ten diverse polymorphs. J Am Chem Soc
141:13887–13897
8. Boldyreva EV (2008) High-pressure diffraction studies of molecular organic solids. A personal view. Acta Crystallogr Sect A Found Crystallogr 64:218–231
9. Fabbiani FPA, Pulham CR (2006) High-pressure studies of pharmaceutical compounds and
energetic materials. Chem Soc Rev 35:932–942
10. Katrusiak A (2008) High-pressure crystallography. Acta Cryst 64:135–148
11. Miletich R, Allan DR, Kuhs WF (2000) High-pressure single-crystal techniques. Rev Mineral
Geochem 41:445–519
12. Sidorov NV, Krasyukov YN, Mukhtarova ÉI, Shkrabo DM (2000) Phase transition and
domain structure in iodoform crystals. Crystallogr Rep 45:288–293
Crystallography Under High Pressures
189