Fig. 2 The solid-state forms of paracetamol obtained from the recrystallisation at high-pressure
methodology. The shaded region designates where it has been shown that paracetamol form II is
stable through differential scanning calorimetry of the pure compound [46]. Filled black squares are
Form II; filled red circle is methanol solvate from Ref. [41]; open circle is methanol solvate from
Ref. [47]; filled blue triangle is dihydrate from Ref. [42]
Fig. 3 A schematic representing the extensive solid-state behaviour of piracetam at high pressure.
Forms III–V are high-pressure polymorphs of piracetam, and the dihydrate can only be accessed at
high pressure through precipitation of the solvent aqueous medium. Reprinted with permission from
Cryst. Growth Des., 2007, 7, 1115–1124. Copyright (2007) American Chemical Society [44]
150
S. A. Moggach and I. D. H. Oswald
methodology. The shaded region designates where it has been shown that paracetamol form II is
stable through differential scanning calorimetry of the pure compound [46]. Filled black squares are
Form II; filled red circle is methanol solvate from Ref. [41]; open circle is methanol solvate from
Ref. [47]; filled blue triangle is dihydrate from Ref. [42]
Fig. 3 A schematic representing the extensive solid-state behaviour of piracetam at high pressure.
Forms III–V are high-pressure polymorphs of piracetam, and the dihydrate can only be accessed at
high pressure through precipitation of the solvent aqueous medium. Reprinted with permission from
Cryst. Growth Des., 2007, 7, 1115–1124. Copyright (2007) American Chemical Society [44]
150
S. A. Moggach and I. D. H. Oswald