Topics in Current Chemistry (2018) 376:46
1 3
for long-time operation (up to 24 h) in the flow set up. Using a “wash and run”
approach, supported catalyst 19 was employed for a single flow experiment using
six different nitroalkenes in a sequential manner, thus producing a small library of
adducts 20a–f (Scheme 10) in good yields and productivity and excellent enantioselectivity. The flow system was run for 1 h to allow the reactants to provide the
products and rinsed for 30 min with CH 2 Cl 2 /THF (10:1) before feeding with a new
solution of reactants.
The structurally simpler and more economic supported squaramide catalyst 21
(Scheme 11) was further developed [46]. The selection of the proper linker was
found to be crucial for the performance of the supported catalyst. The use of catalyst
21 in a continuous flow packed-bed reactor allowed the production of a library of
Scheme 8 Use of supported quinine-like catalyst for continuous flow Michael reactions
38
Reprinted from the journal
1 3
for long-time operation (up to 24 h) in the flow set up. Using a “wash and run”
approach, supported catalyst 19 was employed for a single flow experiment using
six different nitroalkenes in a sequential manner, thus producing a small library of
adducts 20a–f (Scheme 10) in good yields and productivity and excellent enantioselectivity. The flow system was run for 1 h to allow the reactants to provide the
products and rinsed for 30 min with CH 2 Cl 2 /THF (10:1) before feeding with a new
solution of reactants.
The structurally simpler and more economic supported squaramide catalyst 21
(Scheme 11) was further developed [46]. The selection of the proper linker was
found to be crucial for the performance of the supported catalyst. The use of catalyst
21 in a continuous flow packed-bed reactor allowed the production of a library of
Scheme 8 Use of supported quinine-like catalyst for continuous flow Michael reactions
38
Reprinted from the journal