1 3
Topics in Current Chemistry (2019) 377:1
Essential Medicines. Venugopal and colleagues evaluated a ZnO–ZnCr 2 O 4 catalyst
for the continuous preparation of 2‑methylpyrazine through the dehydrocyclization
of glycerol (3) in the presence of a stoichiometric amount of ethylenediamine (46,
Fig. 27). During a 48 h run under optimized conditions, the conversion of glycerol
was maintained constant at 96%, and selectivity for 47 remained at a steady 74%. It
was shown that a combination of both weakly acidic and strongly basic sites is desir‑
able to promote the dehydrocyclization reaction [95].
Fig. 25 Gas‑phase continuous flow synthesis of quinoline (44) from glycerol (3) and aniline (43)
Fig. 26 Gas‑phase continuous pyrolysis of furfural (6) to (methyl)indoles (45)
131
Reprinted from the journal
Topics in Current Chemistry (2019) 377:1
Essential Medicines. Venugopal and colleagues evaluated a ZnO–ZnCr 2 O 4 catalyst
for the continuous preparation of 2‑methylpyrazine through the dehydrocyclization
of glycerol (3) in the presence of a stoichiometric amount of ethylenediamine (46,
Fig. 27). During a 48 h run under optimized conditions, the conversion of glycerol
was maintained constant at 96%, and selectivity for 47 remained at a steady 74%. It
was shown that a combination of both weakly acidic and strongly basic sites is desir‑
able to promote the dehydrocyclization reaction [95].
Fig. 25 Gas‑phase continuous flow synthesis of quinoline (44) from glycerol (3) and aniline (43)
Fig. 26 Gas‑phase continuous pyrolysis of furfural (6) to (methyl)indoles (45)
131
Reprinted from the journal