38
2 Results and Discussion
2.4.1 Economic Considerations
This work presented a 4-step synthetic route to hederagonic acid (1) starting
from oleanolic acid (5). Oleanolic acid can be isolated from the olive tree
(Olea europaea), a profitable commercial source.
[50] While oleanolic acid (5)
is available from 134 commercial sources, also on kg scales, hederagonic acid
(1) is only offered by 19 commercial sources, and exclusively in mg units.
[51]
The cheapest offer found for oleanolic acid (5) was from abcr GmbH, with
it being available for 816.40 e per 1 kg.
[52] In comparison, the cheapest
offer found for hederagonic acid (1) was from MolPort, with 5 mg being
available for 513.00 $ (436.77 e – Currency conversion on 13th December
2017).
[53] Calculating the respective price per amount of substance unveils
the vast price difference of these two natural products, with hederagonic acid
being approximately 100 000 times more expensive than the same amount of
substance of oleanolic acid. The respective values are shown in Figure 2.2.
A cheap and straightforward synthesis can possibly lead to an enhanced
commercial availability of hederagonic acid (1).
HO
H
H
OH
O
H
O
H
H
OH
O
H
HO
Hederagonic acid (1)
42 000.00 e mmol −1
(5 mg, 436.77 e, MolPort)
Oleanolic acid (5)
0.39 e mmol −1
(1 kg, 816.40 e, abcr GmbH)
Figure 2.2: Commercial prices of oleanolic acid (5) and hederagonic acid (1).
2 Results and Discussion
2.4.1 Economic Considerations
This work presented a 4-step synthetic route to hederagonic acid (1) starting
from oleanolic acid (5). Oleanolic acid can be isolated from the olive tree
(Olea europaea), a profitable commercial source.
[50] While oleanolic acid (5)
is available from 134 commercial sources, also on kg scales, hederagonic acid
(1) is only offered by 19 commercial sources, and exclusively in mg units.
[51]
The cheapest offer found for oleanolic acid (5) was from abcr GmbH, with
it being available for 816.40 e per 1 kg.
[52] In comparison, the cheapest
offer found for hederagonic acid (1) was from MolPort, with 5 mg being
available for 513.00 $ (436.77 e – Currency conversion on 13th December
2017).
[53] Calculating the respective price per amount of substance unveils
the vast price difference of these two natural products, with hederagonic acid
being approximately 100 000 times more expensive than the same amount of
substance of oleanolic acid. The respective values are shown in Figure 2.2.
A cheap and straightforward synthesis can possibly lead to an enhanced
commercial availability of hederagonic acid (1).
HO
H
H
OH
O
H
O
H
H
OH
O
H
HO
Hederagonic acid (1)
42 000.00 e mmol −1
(5 mg, 436.77 e, MolPort)
Oleanolic acid (5)
0.39 e mmol −1
(1 kg, 816.40 e, abcr GmbH)
Figure 2.2: Commercial prices of oleanolic acid (5) and hederagonic acid (1).