N
X
C
Hal
O
N
S
P Si
Natural
Products
Solvents
C
C
C
C C
C
249
5.13 Natural Products
249
5.13.3 Nucleotides and Nucleosides
Chemical Shifts and Coupling Constants (δ in ppm, J in Hz)
N
NH
O
O
O
OH
HO
N
N
NH 2
O
O
OH
OH
HO
2 J ab 7.4
3 J cd 3.8
N
N
H
NH 2
O
NH
N
H
O
O
NH
N
H
O
O
N
N
N
H
N
O
NH 2
D 2 O DMSO
a 5.97 5.57
b 7.50 7.31
J ab 7
D 2 O DMSO CDCl 3 TFA
a 8.62 8.12
8.11 8.88
b
12.8
c 8.57 8.10
8.14 9.31
d
7.09
a
a
c
b
b
5.47
1.75
7.28
10.6
7.41
10.82
8.98
11.02
11.0
(in DMSO)
(in DMSO)
(in DMSO)
* interchangeable
(in DMSO)
(in TFA)
N
N
N
H
N
NH 2
a
b
c
d
a
b
c
d
5.75
7.87
3.83
3.77
5.36*
5.06*
5.09
5.04
5.25
3.56
3.66
3.55
3.60
3.95
4.26
7.24
11.3
7.71
1.78
5.79
6.18
3.95
2.08
3 J ab 7.5
3 J bc 5.7
X
C
Hal
O
N
S
P Si
Natural
Products
Solvents
C
C
C
C C
C
249
5.13 Natural Products
249
5.13.3 Nucleotides and Nucleosides
Chemical Shifts and Coupling Constants (δ in ppm, J in Hz)
N
NH
O
O
O
OH
HO
N
N
NH 2
O
O
OH
OH
HO
2 J ab 7.4
3 J cd 3.8
N
N
H
NH 2
O
NH
N
H
O
O
NH
N
H
O
O
N
N
N
H
N
O
NH 2
D 2 O DMSO
a 5.97 5.57
b 7.50 7.31
J ab 7
D 2 O DMSO CDCl 3 TFA
a 8.62 8.12
8.11 8.88
b
12.8
c 8.57 8.10
8.14 9.31
d
7.09
a
a
c
b
b
5.47
1.75
7.28
10.6
7.41
10.82
8.98
11.02
11.0
(in DMSO)
(in DMSO)
(in DMSO)
* interchangeable
(in DMSO)
(in TFA)
N
N
N
H
N
NH 2
a
b
c
d
a
b
c
d
5.75
7.87
3.83
3.77
5.36*
5.06*
5.09
5.04
5.25
3.56
3.66
3.55
3.60
3.95
4.26
7.24
11.3
7.71
1.78
5.79
6.18
3.95
2.08
3 J ab 7.5
3 J bc 5.7