Preface
Fluorescent imaging techniques have broad and profound impact on numerous
research fields including chemical biology, cancer biology, medical imaging, and
pharmaceutical sciences. It provides powerful tools to reinforce medicinal chemistry
research, facilitate drug discovery and development, and help diseases diagnosis and
treatment. This book summarizes the most recent developments of fluorescent
imaging techniques for medicinal chemistry research and biomedical applications.
In Chapter “Fluorescence Molecular Imaging of Medicinal Chemistry in
Cancer”, some fundamental issues of fluorescence molecular imaging including
imaging probe and imaging analysis methods are described, followed by an
introduction to its medical applications in drug discovery. Then organic molecules-based fluorescent imaging probes and inorganic nanoprobes are presented
in Chapter “Organic Fluorescent Probes for Diagnostics and Bio-Imaging” and
Chapter “Inorganic Fluorescent Nanomaterials”, respectively. In Chapter
“Advancements of Second Near-Infrared Biological Window Fluorophores:
Mechanism, Synthesis, and Application In Vivo”, fluorescent imaging at long
wavelengths (1,000–17,000 nm), namely near-infrared window II imaging, is
introduced. Chapter “X-Ray Excited Fluorescent Materials for Medical Application”
covers a novel approach to using X-ray to illuminate materials and produce fluorescence for medical imaging applications. In Chapter “Applications of Fluorescent
Protein-Based Sensors in Bioimaging”, fluorescent proteins used for bioassays and
their applications are reviewed. Chapter “Fluorescent Probes for Diagnostics of
β-Galactosidase: From Micro to Macro” summarizes the fluorescent probes,
nanomaterials, and biomolecules for the detection of an important enzyme (βgalactosidase) and their applications in health monitoring. The last chapter focuses
on the current state of fluorescent imaging techniques, especially endoscopic imaging and Cerenkov luminescence imaging for the diagnosis and treatment of diseases
in clinics.
v
Fluorescent imaging techniques have broad and profound impact on numerous
research fields including chemical biology, cancer biology, medical imaging, and
pharmaceutical sciences. It provides powerful tools to reinforce medicinal chemistry
research, facilitate drug discovery and development, and help diseases diagnosis and
treatment. This book summarizes the most recent developments of fluorescent
imaging techniques for medicinal chemistry research and biomedical applications.
In Chapter “Fluorescence Molecular Imaging of Medicinal Chemistry in
Cancer”, some fundamental issues of fluorescence molecular imaging including
imaging probe and imaging analysis methods are described, followed by an
introduction to its medical applications in drug discovery. Then organic molecules-based fluorescent imaging probes and inorganic nanoprobes are presented
in Chapter “Organic Fluorescent Probes for Diagnostics and Bio-Imaging” and
Chapter “Inorganic Fluorescent Nanomaterials”, respectively. In Chapter
“Advancements of Second Near-Infrared Biological Window Fluorophores:
Mechanism, Synthesis, and Application In Vivo”, fluorescent imaging at long
wavelengths (1,000–17,000 nm), namely near-infrared window II imaging, is
introduced. Chapter “X-Ray Excited Fluorescent Materials for Medical Application”
covers a novel approach to using X-ray to illuminate materials and produce fluorescence for medical imaging applications. In Chapter “Applications of Fluorescent
Protein-Based Sensors in Bioimaging”, fluorescent proteins used for bioassays and
their applications are reviewed. Chapter “Fluorescent Probes for Diagnostics of
β-Galactosidase: From Micro to Macro” summarizes the fluorescent probes,
nanomaterials, and biomolecules for the detection of an important enzyme (βgalactosidase) and their applications in health monitoring. The last chapter focuses
on the current state of fluorescent imaging techniques, especially endoscopic imaging and Cerenkov luminescence imaging for the diagnosis and treatment of diseases
in clinics.
v