Fig. 2 Examples of intraoperative imaging for detection and guidance of surgical intervention. (a)
Images from a glioblastoma patient. Left, an MRI scan of the tumor following 5-ALA administration. Arrows indicate a part of the tumor showing increase of signal following 5-ALA administration. Center and right, intraoperative images showing tumor contrast of the frontal lobe under white
light and violet-blue excitation fluorescence, respectively [42]. (b) NIR fluorescence imaging of
lymph node biopsy from a breast cancer patient following ICG injection during percutaneous
assessment (upper row) and in exposed sentinel lymph node (lower row). NIR fluorescence light
penetrates tissue, allowing noninvasive imaging method of lymph nodes and lymphatic flow
[43]. (c) NIR fluorescence imaging of the ureter during abdominal surgery following intravenous
administration of methylene blue [44]. Referenced figure panels have been adapted and reprinted
with permission of their respective owners
The Present and Future of Optical Imaging Technologies in the Clinic:. . .
213
Images from a glioblastoma patient. Left, an MRI scan of the tumor following 5-ALA administration. Arrows indicate a part of the tumor showing increase of signal following 5-ALA administration. Center and right, intraoperative images showing tumor contrast of the frontal lobe under white
light and violet-blue excitation fluorescence, respectively [42]. (b) NIR fluorescence imaging of
lymph node biopsy from a breast cancer patient following ICG injection during percutaneous
assessment (upper row) and in exposed sentinel lymph node (lower row). NIR fluorescence light
penetrates tissue, allowing noninvasive imaging method of lymph nodes and lymphatic flow
[43]. (c) NIR fluorescence imaging of the ureter during abdominal surgery following intravenous
administration of methylene blue [44]. Referenced figure panels have been adapted and reprinted
with permission of their respective owners
The Present and Future of Optical Imaging Technologies in the Clinic:. . .
213