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26. Jandera P (2005) Liquid chromatography | normal phase. In: Encyclopedia of analytical science. Elsevier, pp 142–152. https://doi.org/10.1016/b0-12-369397-7/00324-1
27. Scott RPW (2000) Chromatography: Liquid | mechanisms: normal phase. In: Encyclopedia of
separation science. Elsevier, pp 706–711. https://doi.org/10.1016/b0-12-226770-2/00301-x
28. Jiang P, Lucy CA (2016) Coupling normal phase liquid chromatography with electrospray
ionization mass spectrometry: strategies and applications. Anal Methods:6478–6488. https://
doi.org/10.1039/c6ay01419d
29. Abbott SR (1980) Practical aspects of normal-phase chromatography. J Chromatogr Sci
18(10):540–550. https://doi.org/10.1093/chromsci/18.10.540
30. Patti GJ, Yanes O, Siuzdak GI (2012) Metabolomics: the apogee of the omics trilogy. Nat Rev
Mol Cell Biol:263–269. https://doi.org/10.1038/nrm3314
31. Dettmer K, Aronov PA, Hammock BD Mass spectrometry-based metabolomics. Mass
Spectrom Rev 26(1):51–78. https://doi.org/10.1002/mas.20108
32. Patterson RE, Ducrocq AJ, McDougall DJ, Garrett TJ, Yost RA (2015) Comparison of blood
plasma sample preparation methods for combined LC-MS lipidomics and metabolomics.
J Chromatogr B Anal Technol Biomed Life Sci 1002:260–266. https://doi.org/10.1016/j.
jchromb.2015.08.018
33. Cutillas P (2005) Principles of nanoflow liquid chromatography and applications to proteomics. Curr Nanosci 1(1):65–71. https://doi.org/10.2174/1573413052953093
34. Alpert AJ (1990) Hydrophilic-interaction chromatography for the separation of peptides,
nucleic acids and other polar compounds. J Chromatogr A 499(C):177–196. https://doi.
org/10.1016/S0021-9673(00)96972-3
35. Simon R, Enjalbert Q, Biarc J, Lemoine J, Salvador A (2012) Evaluation of Hydrophilic
Interaction Chromatography (HILIC) versus C18 reversed-phase chromatography for targeted
quantification of peptides by mass spectrometry. J Chromatogr A 1264:31–39. https://doi.
org/10.1016/j.chroma.2012.09.059
36. Naser FJ, Mahieu NG, Wang L, Spalding JL, Johnson SL, Patti GJ (2018) Two complementary
reversed-phase separations for comprehensive coverage of the semipolar and nonpolar metabolome. Anal Bioanal Chem 410(4):1287–1297. https://doi.org/10.1007/s00216-017-0768-x
37. Martin AJP, Synge RLM (1941) A new form of chromatogram employing two liquid phases.
Biochem J 35(12):1358–1368
38. Roessner U, Wagner C, Kopka J, Tretheway RN, Willmitzer L (2001) Simultaneous analysis
of metabolites in tuber by gas chromatography-mass spectrometry. Plant J 23:1
39. Castrillo JI, Hayes A, Mohammed S, Gaskell SJ, Oliver SG (2003) An optimized protocol for metabolome analysis in yeast using direct infusion electrospray mass spectrometry.
Phytochemistry 62:929–937
40. Halket JM, Waterman D, Przyborowska AM, Patel RKP, Fraser PD, Bramley PM (2005)
Chemical derivatization and mass spectral libraries in metabolic profiling by GC/MS and LC/
MS/MS. J Exp Bot 56(410):219–243. https://doi.org/10.1093/jxb/eri069
41. Jonsson P, Johansson AI, Gullberg J, Trygg J, A J, Grung B, Marklund S, Sjöström M, Antti
H, Moritz T (2005) High-throughput data analysis for detecting and identifying differences
between samples in GC/MS-based metabolomic analyses. Anal Chem 77(17):5635–5642.
https://doi.org/10.1021/ac050601e
42. Monnig CA, Kennedy RT (2014) Capillary electrophoresis. Food Toxic Anal Tech Strateg Dev
1997(12):561–597. https://doi.org/10.1021/acs.analchem.5b04125
43. Ewing AG, Wallingford RA, Olefirowicz TM (1989) Capillary electrophoresis. Anal Chem
61(4):292A–303A. https://doi.org/10.1021/ac00179a002
44. VanOrman BB, Liversidge GG, McIntire GL, Olefirowicz TM, Ewing AG (1990) Effects of
buffer composition on electroosmotic flow in capillary electrophoresis. J Microcolumn Sep
2(4):176–180. https://doi.org/10.1002/mcs.1220020404
45. Olivares JA, Nguyen NT, Yonker CR, Smith RD (1987) On-line mass spectrometric detection for capillary zone electrophoresis. Anal Chem 59(8):1230–1232. https://doi.org/10.1021/
ac00135a034
E. S. Rivera et al.
26. Jandera P (2005) Liquid chromatography | normal phase. In: Encyclopedia of analytical science. Elsevier, pp 142–152. https://doi.org/10.1016/b0-12-369397-7/00324-1
27. Scott RPW (2000) Chromatography: Liquid | mechanisms: normal phase. In: Encyclopedia of
separation science. Elsevier, pp 706–711. https://doi.org/10.1016/b0-12-226770-2/00301-x
28. Jiang P, Lucy CA (2016) Coupling normal phase liquid chromatography with electrospray
ionization mass spectrometry: strategies and applications. Anal Methods:6478–6488. https://
doi.org/10.1039/c6ay01419d
29. Abbott SR (1980) Practical aspects of normal-phase chromatography. J Chromatogr Sci
18(10):540–550. https://doi.org/10.1093/chromsci/18.10.540
30. Patti GJ, Yanes O, Siuzdak GI (2012) Metabolomics: the apogee of the omics trilogy. Nat Rev
Mol Cell Biol:263–269. https://doi.org/10.1038/nrm3314
31. Dettmer K, Aronov PA, Hammock BD Mass spectrometry-based metabolomics. Mass
Spectrom Rev 26(1):51–78. https://doi.org/10.1002/mas.20108
32. Patterson RE, Ducrocq AJ, McDougall DJ, Garrett TJ, Yost RA (2015) Comparison of blood
plasma sample preparation methods for combined LC-MS lipidomics and metabolomics.
J Chromatogr B Anal Technol Biomed Life Sci 1002:260–266. https://doi.org/10.1016/j.
jchromb.2015.08.018
33. Cutillas P (2005) Principles of nanoflow liquid chromatography and applications to proteomics. Curr Nanosci 1(1):65–71. https://doi.org/10.2174/1573413052953093
34. Alpert AJ (1990) Hydrophilic-interaction chromatography for the separation of peptides,
nucleic acids and other polar compounds. J Chromatogr A 499(C):177–196. https://doi.
org/10.1016/S0021-9673(00)96972-3
35. Simon R, Enjalbert Q, Biarc J, Lemoine J, Salvador A (2012) Evaluation of Hydrophilic
Interaction Chromatography (HILIC) versus C18 reversed-phase chromatography for targeted
quantification of peptides by mass spectrometry. J Chromatogr A 1264:31–39. https://doi.
org/10.1016/j.chroma.2012.09.059
36. Naser FJ, Mahieu NG, Wang L, Spalding JL, Johnson SL, Patti GJ (2018) Two complementary
reversed-phase separations for comprehensive coverage of the semipolar and nonpolar metabolome. Anal Bioanal Chem 410(4):1287–1297. https://doi.org/10.1007/s00216-017-0768-x
37. Martin AJP, Synge RLM (1941) A new form of chromatogram employing two liquid phases.
Biochem J 35(12):1358–1368
38. Roessner U, Wagner C, Kopka J, Tretheway RN, Willmitzer L (2001) Simultaneous analysis
of metabolites in tuber by gas chromatography-mass spectrometry. Plant J 23:1
39. Castrillo JI, Hayes A, Mohammed S, Gaskell SJ, Oliver SG (2003) An optimized protocol for metabolome analysis in yeast using direct infusion electrospray mass spectrometry.
Phytochemistry 62:929–937
40. Halket JM, Waterman D, Przyborowska AM, Patel RKP, Fraser PD, Bramley PM (2005)
Chemical derivatization and mass spectral libraries in metabolic profiling by GC/MS and LC/
MS/MS. J Exp Bot 56(410):219–243. https://doi.org/10.1093/jxb/eri069
41. Jonsson P, Johansson AI, Gullberg J, Trygg J, A J, Grung B, Marklund S, Sjöström M, Antti
H, Moritz T (2005) High-throughput data analysis for detecting and identifying differences
between samples in GC/MS-based metabolomic analyses. Anal Chem 77(17):5635–5642.
https://doi.org/10.1021/ac050601e
42. Monnig CA, Kennedy RT (2014) Capillary electrophoresis. Food Toxic Anal Tech Strateg Dev
1997(12):561–597. https://doi.org/10.1021/acs.analchem.5b04125
43. Ewing AG, Wallingford RA, Olefirowicz TM (1989) Capillary electrophoresis. Anal Chem
61(4):292A–303A. https://doi.org/10.1021/ac00179a002
44. VanOrman BB, Liversidge GG, McIntire GL, Olefirowicz TM, Ewing AG (1990) Effects of
buffer composition on electroosmotic flow in capillary electrophoresis. J Microcolumn Sep
2(4):176–180. https://doi.org/10.1002/mcs.1220020404
45. Olivares JA, Nguyen NT, Yonker CR, Smith RD (1987) On-line mass spectrometric detection for capillary zone electrophoresis. Anal Chem 59(8):1230–1232. https://doi.org/10.1021/
ac00135a034
E. S. Rivera et al.