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© Springer Nature B.V. 2020
G. Sindona et al. (eds.), Toxic Chemical and Biological Agents, NATO Science
for Peace and Security Series A: Chemistry and Biology,
https://doi.org/10.1007/978-94-024-2041-8_30
Chapter 30
Magnetically Targeted Delivery
of Sorafenib Through Magnetic Solid Lipid
Nanoparticles Towards Treatment
of Hepatocellular Carcinoma
F. Vischio, N. Depalo, R. M. Iacobazzi, M. P. Scavo, S. Villa, F. Canepa,
S. Hee Lee, B. Chul Lee, E. Fanizza, I. Arduino, V. Laquintana, A. Lopalco,
A. Lopedota, A. Cutrignelli, M. Striccoli, A. Agostiano, N. Denora,
and M. L. Curri
Sorafenib is an anticancer drug with multikinase inhibitor activity and it is only that
has proved to significantly prolong the survival time in patients with advanced hepatocellular carcinoma (HCC). However, sorafenib is characterized by severe toxic
F. Vischio (*) · E. Fanizza · A. Agostiano · M. L. Curri
Istituto per i Processi Chimico-Fisici-CNR SS Bari, Bari, Italy
Università degli Studi di Bari Aldo Moro, Dipartimento di Chimica, Bari, Italy
e-mail: f.vischio@ba.ipcf.cnr.it
N. Depalo · M. Striccoli
Istituto per i Processi Chimico-Fisici-CNR SS Bari, Bari, Italy
R. M. Iacobazzi
Istituto Tumori IRCCS Giovanni Paolo II, Bari, Italy
M. P. Scavo
National Institute of Gastroenterology “S. De Bellis”, Personalized Medicine Laboratory,
Bari, Italy
S. Villa · F. Canepa
Dipartimento di Chimica e Chimica Industriale, Università di Genova, Genoa, Italy
S. H. Lee · B. C. Lee
Seoul National University College of Medicine, Seoul National University Bundang Hospital,
Seongnam, Republic of Korea
I. Arduino · V. Laquintana · A. Lopalco · A. Lopedota · A. Cutrignelli
Università degli Studi di Bari Aldo Moro, Dipartimento di Farmacia, Scienze del Farmaco,
Bari, Italy
N. Denora
Istituto per i Processi Chimico-Fisici-CNR SS Bari, Bari, Italy
Università degli Studi di Bari Aldo Moro, Dipartimento di Farmacia, Scienze del Farmaco,
Bari, Italy