207
59. Blanksby SJ, Mitchell TW (2010) Advances in mass spectrometry for lipidomics. Annu Rev
Anal Chem 3:433–465
60. Banoub JH, Newton RP, Esmans E, Ewing DF, Mackenzie G (2005) Recent developments in
mass spectrometry for the characterization of nucleosides, nucleotides, oligonucleotides, and
nucleic acids. Chem Rev 105:1869–1915
61. Zhang Y, Go EP, Desaire H (2008) Maximizing coverage of glycosylation heterogeneity in MALDI-MS analysis of glycoproteins with up to 27 glycosylation sites. Anal Chem
80:3144–3158
62. Laštovičková M, Chmelik J, Bobalova J (2009) The combination of simple MALDI matrices for the improvement of intact glycoproteins and glycans analysis. Int J Mass Spectrom
281:82–88
63. Kamath VP, Diedrich P, Hindsgaul O (1996) Use of diethyl squarate for the coupling of oligosaccharide amines to carrier proteins and characterization of the resulting neoglycoproteins by
MALDI-TOF mass spectrometry. Glycoconj J 13:315–319
64. Issaq HJ, Conrads TP, Prieto DA, Tirumalai R, Veenstra TD (2003) SELDI-TOF MS for diagnostic proteomics. Anal Chem 75:148A–155A
65. Liu C (2011) The application of SELDI-TOF-MS in clinical diagnosis of cancers. J Biomed
Biotechnol 6:245821
66. Chernyak A, Karavanov A, Ogawa Y, Kováč P (2001) Conjugating oligosaccharides to proteins
by squaric acid diester chemistry: rapid monitoring of the progress of conjugation, and recovery of the unused ligand. Carbohydr Res 330:479–486
67. Jahouh F, Saksena R, Aiello D, Napoli A, Sindona G, Kováč P, Banoub JH (2010) Glycation
sites in neoglycoconjugates from the terminal monosaccharide antigen of the O-PS of Vibrio
cholerae O1, serotype Ogawa, and BSA revealed by matrix-assisted laser desorption- ionization tandem mass spectrometry. J Mass Spectrom (10):1148–1159
68. Jahouh F, Saksena R, Kováč P, Banoub JH (2012) Revealing the glycation sites in synthetic
neoglycoconjugates formed by conjugation of the antigenic monosaccharide hapten of Vibrio
cholerae O1 serotype Ogawa with the BSA protein carrier using LC-ESI-QqTOF-MS/MS. J
Mass Spectrom 47:890–900
69. Jahouh F, Hou SJ, Kováč P, Banoub JH (2011) Determination of the glycation sites of Bacillus
anthracis neoglycoconjugate vaccine by MALDI-TOF/TOF-CID-MS/MS and LC-ESIQqTOF-tandem mass spectrometry. J Mass Spectrom 46:993–1003
70. Jahouh F, Hou SJ, Kováč P, Banoub JH (2012) Determination of glycation sites by tandem
mass spectrometry in a synthetic lactose-bovine serum albumin conjugate, a vaccine model
prepared by dialkyl squarate chemistry. Rapid Commun Mass Spectrom 26:749–758
71. Jahouh F, Xu P, Vann WF, Kováč P, Banoub JH (2013) Mapping the glycation sites in the
neoglycoconjugate from hexasaccharide antigen of Vibrio cholerae , serotype Ogawa and the
recombinant tetanus toxin C-fragment carrier. J Mass Spectrom 48:1083–1090
72. McCarthy PC, Saksena R, Peterson DC, Lee CH, An Y, Cipollo JF, Vann WF (2013)
Chemoenzymatic synthesis of immunogenic meningococcal group C polysialic acid-tetanus
Hc fragment glycoconjugates. Glycoconj J 30:857–870
73. Roepstorff P, Fohlman J (1984) Proposal for a common nomenclature for sequence ions in
mass spectra of peptides. Biol Mass Spectrom 11:601
74. Johnson RS, Martin SA, Biemann K, Stults JT, Watson JT (1987) Novel fragmentation process
of peptides by collision-induced decomposition in a tandem mass spectrometer: differentiation
of leucine and isoleucine. Anal Chem 59:2621–2625
75. Domon B, Costello C (1988) A systematic nomenclature for carbohydrate fragmentations in
FAB-MS/MS spectra of glycoconjugates. Glycoconj J 5:397–409
76. Mock M, Fouet A (2001) Anthrax. Annu Rev Microbiol 55:647–671
77. Pries FG (1993) In: Sonenshein AL, Hoch JA, Losick R (eds) Bacillus subtilis and other grampositive bacteria: biochemistry, physiology, and molecular biology. American Society for
Microbiology, Washington, DC, p 3
11 Defense Against Biological Terrorism: Vaccines and Their Characterizations
59. Blanksby SJ, Mitchell TW (2010) Advances in mass spectrometry for lipidomics. Annu Rev
Anal Chem 3:433–465
60. Banoub JH, Newton RP, Esmans E, Ewing DF, Mackenzie G (2005) Recent developments in
mass spectrometry for the characterization of nucleosides, nucleotides, oligonucleotides, and
nucleic acids. Chem Rev 105:1869–1915
61. Zhang Y, Go EP, Desaire H (2008) Maximizing coverage of glycosylation heterogeneity in MALDI-MS analysis of glycoproteins with up to 27 glycosylation sites. Anal Chem
80:3144–3158
62. Laštovičková M, Chmelik J, Bobalova J (2009) The combination of simple MALDI matrices for the improvement of intact glycoproteins and glycans analysis. Int J Mass Spectrom
281:82–88
63. Kamath VP, Diedrich P, Hindsgaul O (1996) Use of diethyl squarate for the coupling of oligosaccharide amines to carrier proteins and characterization of the resulting neoglycoproteins by
MALDI-TOF mass spectrometry. Glycoconj J 13:315–319
64. Issaq HJ, Conrads TP, Prieto DA, Tirumalai R, Veenstra TD (2003) SELDI-TOF MS for diagnostic proteomics. Anal Chem 75:148A–155A
65. Liu C (2011) The application of SELDI-TOF-MS in clinical diagnosis of cancers. J Biomed
Biotechnol 6:245821
66. Chernyak A, Karavanov A, Ogawa Y, Kováč P (2001) Conjugating oligosaccharides to proteins
by squaric acid diester chemistry: rapid monitoring of the progress of conjugation, and recovery of the unused ligand. Carbohydr Res 330:479–486
67. Jahouh F, Saksena R, Aiello D, Napoli A, Sindona G, Kováč P, Banoub JH (2010) Glycation
sites in neoglycoconjugates from the terminal monosaccharide antigen of the O-PS of Vibrio
cholerae O1, serotype Ogawa, and BSA revealed by matrix-assisted laser desorption- ionization tandem mass spectrometry. J Mass Spectrom (10):1148–1159
68. Jahouh F, Saksena R, Kováč P, Banoub JH (2012) Revealing the glycation sites in synthetic
neoglycoconjugates formed by conjugation of the antigenic monosaccharide hapten of Vibrio
cholerae O1 serotype Ogawa with the BSA protein carrier using LC-ESI-QqTOF-MS/MS. J
Mass Spectrom 47:890–900
69. Jahouh F, Hou SJ, Kováč P, Banoub JH (2011) Determination of the glycation sites of Bacillus
anthracis neoglycoconjugate vaccine by MALDI-TOF/TOF-CID-MS/MS and LC-ESIQqTOF-tandem mass spectrometry. J Mass Spectrom 46:993–1003
70. Jahouh F, Hou SJ, Kováč P, Banoub JH (2012) Determination of glycation sites by tandem
mass spectrometry in a synthetic lactose-bovine serum albumin conjugate, a vaccine model
prepared by dialkyl squarate chemistry. Rapid Commun Mass Spectrom 26:749–758
71. Jahouh F, Xu P, Vann WF, Kováč P, Banoub JH (2013) Mapping the glycation sites in the
neoglycoconjugate from hexasaccharide antigen of Vibrio cholerae , serotype Ogawa and the
recombinant tetanus toxin C-fragment carrier. J Mass Spectrom 48:1083–1090
72. McCarthy PC, Saksena R, Peterson DC, Lee CH, An Y, Cipollo JF, Vann WF (2013)
Chemoenzymatic synthesis of immunogenic meningococcal group C polysialic acid-tetanus
Hc fragment glycoconjugates. Glycoconj J 30:857–870
73. Roepstorff P, Fohlman J (1984) Proposal for a common nomenclature for sequence ions in
mass spectra of peptides. Biol Mass Spectrom 11:601
74. Johnson RS, Martin SA, Biemann K, Stults JT, Watson JT (1987) Novel fragmentation process
of peptides by collision-induced decomposition in a tandem mass spectrometer: differentiation
of leucine and isoleucine. Anal Chem 59:2621–2625
75. Domon B, Costello C (1988) A systematic nomenclature for carbohydrate fragmentations in
FAB-MS/MS spectra of glycoconjugates. Glycoconj J 5:397–409
76. Mock M, Fouet A (2001) Anthrax. Annu Rev Microbiol 55:647–671
77. Pries FG (1993) In: Sonenshein AL, Hoch JA, Losick R (eds) Bacillus subtilis and other grampositive bacteria: biochemistry, physiology, and molecular biology. American Society for
Microbiology, Washington, DC, p 3
11 Defense Against Biological Terrorism: Vaccines and Their Characterizations