x
environmental assessment and preparedness, and analysis of sublethal effects at the
molecular level were examined.
The participants were introduced to the state-of-the-art biological agent detection systems using soft-ionization mass spectrometry, tandem mass spectrometry,
and biological sensors and their efficacy in measuring very low concentrations
(pico- to femtomoles). Primary considerations in quantitative analysis with a focus
on MS and MS/MS and the role of MS and ion mobility on metabolomics were also
presented.
A discussion on several types of food bacteria, such as Salmonella, Campylobacter,
and Enterohemorrhagic Escherichia coli, which are among the most common foodborne pathogens that could be used as a terror agent, took place. Their detection and
disease treatment were also defined.
In addition, the participants were also introduced to the different modes of tandem mass spectrometry such as DDA and DIA scans.
Furthermore, a general description of the category A bacterial bioagents Bacillus
anthracis (anthrax) Yersinia pestis (plague) Francisella tularensis (tularemia),
which are responsible for the transmission, dissemination and causing high mortality rates and create panic in the public will be presented. Medical treatment was
conferred for symptoms. Considering that these biological agents may be engineered to have multi-antibiotic resistance, prevention using synthetic neoglyconjugate vaccines was also examined.
Finally, the participants were initiated to the novel field of imaging mass spectrometry, which allows for the mapping of disease biomarkers and metabolic
changes in tissue and single cells.
All the participants who attended this NATO-ASI were graduate students, postdoctoral fellows and faculty, and military scientists. The participants presented short
oral presentations and posters. In addition, all participants were given the opportunity to have their contribution ready for publishing in NATO Science for Peace and
Security Series A: Chemistry and Biology (Springer) as short note.
St Johns, NL, Canada
Joseph H. Banoub
Cosenza, Calabria, Italy
Maria Luisa Di Gioa
Preface
environmental assessment and preparedness, and analysis of sublethal effects at the
molecular level were examined.
The participants were introduced to the state-of-the-art biological agent detection systems using soft-ionization mass spectrometry, tandem mass spectrometry,
and biological sensors and their efficacy in measuring very low concentrations
(pico- to femtomoles). Primary considerations in quantitative analysis with a focus
on MS and MS/MS and the role of MS and ion mobility on metabolomics were also
presented.
A discussion on several types of food bacteria, such as Salmonella, Campylobacter,
and Enterohemorrhagic Escherichia coli, which are among the most common foodborne pathogens that could be used as a terror agent, took place. Their detection and
disease treatment were also defined.
In addition, the participants were also introduced to the different modes of tandem mass spectrometry such as DDA and DIA scans.
Furthermore, a general description of the category A bacterial bioagents Bacillus
anthracis (anthrax) Yersinia pestis (plague) Francisella tularensis (tularemia),
which are responsible for the transmission, dissemination and causing high mortality rates and create panic in the public will be presented. Medical treatment was
conferred for symptoms. Considering that these biological agents may be engineered to have multi-antibiotic resistance, prevention using synthetic neoglyconjugate vaccines was also examined.
Finally, the participants were initiated to the novel field of imaging mass spectrometry, which allows for the mapping of disease biomarkers and metabolic
changes in tissue and single cells.
All the participants who attended this NATO-ASI were graduate students, postdoctoral fellows and faculty, and military scientists. The participants presented short
oral presentations and posters. In addition, all participants were given the opportunity to have their contribution ready for publishing in NATO Science for Peace and
Security Series A: Chemistry and Biology (Springer) as short note.
St Johns, NL, Canada
Joseph H. Banoub
Cosenza, Calabria, Italy
Maria Luisa Di Gioa
Preface