110. Daughton CG, Ternes TA (1999) Pharmaceuticals and personal care products in the environment: agents of subtle change? Environ Health Perspect 107(suppl 6):907–938
111. Benotti MJ, Trenholm RA, Vanderford BJ, Holady JC, Stanford BD, Snyder SA (2009)
Pharmaceuticals and endocrine disrupting compounds in US drinking water. Environ Sci
Technol 43(3):597–603
112. Ahmed MBM, Rajapaksha AU, Lim JE, Vu NT, Kim IS, Kang HM, Lee SS, Ok YS (2015)
Distribution and accumulative pattern of tetracyclines and sulfonamides in edible vegetables
of cucumber, tomato, and lettuce. J Agric Food Chem 63(2):398–405
113. Sterling TM (1994) Mechanisms of herbicide absorption across plant membranes and accumulation in plant cells. Weed Sci 42(2):263–276
114. Wu X, Ernst F, Conkle JL, Gan J (2013) Comparative uptake and translocation of pharmaceutical and personal care products (PPCPs) by common vegetables. Environ Int 60:15–22
115. Klampfl CW (2019) Metabolization of pharmaceuticals by plants after uptake from water and
soil: a review. TrAC Trends Anal Chem 111:13–26
116. Kvesitadze G, Khatisashvili G, Sadunishvili T, Ramsden JJ (2006) Biochemical mechanisms
of detoxification in higher plants: basis of phytoremediation. Springer, Berlin
117. Wills RB, Wong AW, Scriven FM, Greenfield H (1984) Nutrient composition of Chinese
vegetables. J Agric Food Chem 32(2):413–416
118. Banihani SA (2017) Radish (Raphanus sativus) and diabetes. Nutrients 9(9):1014
119. Chuang Y-H, Zhang Y, Zhang W, Boyd SA, Li H (2015) Comparison of accelerated solvent
extraction and quick, easy, cheap, effective, rugged and safe method for extraction and
determination of pharmaceuticals in vegetables. J Chromatogr A 1404:1–9
120. Wu X, Conkle JL, Gan J (2012) Multi-residue determination of pharmaceutical and personal
care products in vegetables. J Chromatogr A 1254:78–86
121. Martínez-Piernas AB, Polo-López M, Fernández-Ibáñez P, Agüera A (2018) Validation and
application of a multiresidue method based on liquid chromatography-tandem mass spectrometry for evaluating the plant uptake of 74 microcontaminants in crops irrigated with treated
municipal wastewater. J Chromatogr A 1534:10–21
122. Ferro G, Polo-Lo’pez MI, Martínez-Piernas AB, Fernandez-Ibanez P, Agüera A, Rizzo L
(2015) Cross-contamination of residual emerging contaminants and antibiotic resistant bacteria in lettuce crops and soil irrigated with wastewater treated by sunlight/H2O2. Environ Sci
Technol 49(18):11096–11104
123. Amelin V, Avdeeva N (2018) Determination of penicillins G and V in vegetables and fruits by
exact masses of ions of protonated adducts with methanol by ultra-high-performance liquid
chromatography–time-of-flight high resolution mass spectrometry. J Anal Chem 73
(9):922–928
124. Runnqvist H, Bak SA, Hansen M, Styrishave B, Halling-Sørensen B, Björklund E (2010)
Determination of pharmaceuticals in environmental and biological matrices using pressurised
liquid extraction—are we developing sound extraction methods? J Chromatogr A 1217
(16):2447–2470
125. Malchi T, Maor Y, Tadmor G, Shenker M, Chefetz B (2014) Irrigation of root vegetables with
treated wastewater: evaluating uptake of pharmaceuticals and the associated human health
risks. Environ Sci Technol 48(16):9325–9333
126. Goldstein M, Shenker M, Chefetz B (2014) Insights into the uptake processes of wastewaterborne pharmaceuticals by vegetables. Environ Sci Technol 48(10):5593–5600
127. Raut P, Bhosle D, Janghel A, Deo S, Verma C, Kumar SS, Agrawal M, Amit N, Sharma M,
Giri T (2015) Emerging pressurized liquid extraction (PLE) techniques as an innovative green
technologies for the effective extraction of the active phytopharmaceuticals. Res J Pharm
Technol 8(6):800–810
128. Santiago S, Roll DM, Ray C, Williams C, Moravcik P, Knopf A (2016) Effects of soil
moisture depletion on vegetable crop uptake of pharmaceuticals and personal care products
(PPCPs). Environ Sci Pollut Res 23(20):20257–20268
486
R. Manasfi et al.
111. Benotti MJ, Trenholm RA, Vanderford BJ, Holady JC, Stanford BD, Snyder SA (2009)
Pharmaceuticals and endocrine disrupting compounds in US drinking water. Environ Sci
Technol 43(3):597–603
112. Ahmed MBM, Rajapaksha AU, Lim JE, Vu NT, Kim IS, Kang HM, Lee SS, Ok YS (2015)
Distribution and accumulative pattern of tetracyclines and sulfonamides in edible vegetables
of cucumber, tomato, and lettuce. J Agric Food Chem 63(2):398–405
113. Sterling TM (1994) Mechanisms of herbicide absorption across plant membranes and accumulation in plant cells. Weed Sci 42(2):263–276
114. Wu X, Ernst F, Conkle JL, Gan J (2013) Comparative uptake and translocation of pharmaceutical and personal care products (PPCPs) by common vegetables. Environ Int 60:15–22
115. Klampfl CW (2019) Metabolization of pharmaceuticals by plants after uptake from water and
soil: a review. TrAC Trends Anal Chem 111:13–26
116. Kvesitadze G, Khatisashvili G, Sadunishvili T, Ramsden JJ (2006) Biochemical mechanisms
of detoxification in higher plants: basis of phytoremediation. Springer, Berlin
117. Wills RB, Wong AW, Scriven FM, Greenfield H (1984) Nutrient composition of Chinese
vegetables. J Agric Food Chem 32(2):413–416
118. Banihani SA (2017) Radish (Raphanus sativus) and diabetes. Nutrients 9(9):1014
119. Chuang Y-H, Zhang Y, Zhang W, Boyd SA, Li H (2015) Comparison of accelerated solvent
extraction and quick, easy, cheap, effective, rugged and safe method for extraction and
determination of pharmaceuticals in vegetables. J Chromatogr A 1404:1–9
120. Wu X, Conkle JL, Gan J (2012) Multi-residue determination of pharmaceutical and personal
care products in vegetables. J Chromatogr A 1254:78–86
121. Martínez-Piernas AB, Polo-López M, Fernández-Ibáñez P, Agüera A (2018) Validation and
application of a multiresidue method based on liquid chromatography-tandem mass spectrometry for evaluating the plant uptake of 74 microcontaminants in crops irrigated with treated
municipal wastewater. J Chromatogr A 1534:10–21
122. Ferro G, Polo-Lo’pez MI, Martínez-Piernas AB, Fernandez-Ibanez P, Agüera A, Rizzo L
(2015) Cross-contamination of residual emerging contaminants and antibiotic resistant bacteria in lettuce crops and soil irrigated with wastewater treated by sunlight/H2O2. Environ Sci
Technol 49(18):11096–11104
123. Amelin V, Avdeeva N (2018) Determination of penicillins G and V in vegetables and fruits by
exact masses of ions of protonated adducts with methanol by ultra-high-performance liquid
chromatography–time-of-flight high resolution mass spectrometry. J Anal Chem 73
(9):922–928
124. Runnqvist H, Bak SA, Hansen M, Styrishave B, Halling-Sørensen B, Björklund E (2010)
Determination of pharmaceuticals in environmental and biological matrices using pressurised
liquid extraction—are we developing sound extraction methods? J Chromatogr A 1217
(16):2447–2470
125. Malchi T, Maor Y, Tadmor G, Shenker M, Chefetz B (2014) Irrigation of root vegetables with
treated wastewater: evaluating uptake of pharmaceuticals and the associated human health
risks. Environ Sci Technol 48(16):9325–9333
126. Goldstein M, Shenker M, Chefetz B (2014) Insights into the uptake processes of wastewaterborne pharmaceuticals by vegetables. Environ Sci Technol 48(10):5593–5600
127. Raut P, Bhosle D, Janghel A, Deo S, Verma C, Kumar SS, Agrawal M, Amit N, Sharma M,
Giri T (2015) Emerging pressurized liquid extraction (PLE) techniques as an innovative green
technologies for the effective extraction of the active phytopharmaceuticals. Res J Pharm
Technol 8(6):800–810
128. Santiago S, Roll DM, Ray C, Williams C, Moravcik P, Knopf A (2016) Effects of soil
moisture depletion on vegetable crop uptake of pharmaceuticals and personal care products
(PPCPs). Environ Sci Pollut Res 23(20):20257–20268
486
R. Manasfi et al.
