22. Nannou CI, Boti VI, Albanis TA (2019) A modified QuEChERS approach for the analysis of
pharmaceuticals in sediments by LC-Orbitrap HRMS. Anal Bioanal Chem 411(7):1383–1396
23. Pinto CG, Laespada MEF, Martín SH, Ferreira AMC, Pavón JLP, Cordero BM (2010)
Simplified QuEChERS approach for the extraction of chlorinated compounds from soil
samples. Talanta 81(1–2):385–391
24. Plössl F, Giera M, Bracher F (2006) Multiresidue analytical method using dispersive solidphase extraction and gas chromatography/ion trap mass spectrometry to determine pharmaceuticals in whole blood. J Chromatogr A 1135(1):19–26
25. Lehotay SJ, Tully J, Garca AV, Contreras M, Mol H, Heinke V, Anspach T, Lach G, Fussell R,
Mastovska K (2007) Determination of pesticide residues in foods by acetonitrile extraction
and partitioning with magnesium sulfate: collaborative study. J AOAC Int 90(2):485–520
26. CEN (2008) Foods of plant origin-Determination of pesticide residues using GC-MS and/or
LC-MS/MS following acetonitrile extraction/partitioning and clean-up by dispersive SPE.
QuEChERS-method EN 15662:2008
27. De Castro ML, Priego-Capote F (2010) Soxhlet extraction: past and present panacea. J
Chromatogr A 1217(16):2383–2389
28. Bartha B, Huber C, Harpaintner R, Schröder P (2010) Effects of acetaminophen in Brassica
juncea L. Czern.: investigation of uptake, translocation, detoxification, and the induced
defense pathways. Environ Sci Pollut Res 17(9):1553–1562
29. Pavlović DM, Babić S, Horvat AJ, Kaštelan-Macan M (2007) Sample preparation in analysis
of pharmaceuticals. TrAC Trends Anal Chem 26(11):1062–1075
30. Klein C, O’Connor S, Locke J, Aga D (2008) Sample preparation and analysis of solid-bound
pharmaceuticals. CRC Press, Boca Raton
31. Carter LJ, Williams M, Martin S, Kamaludeen SP, Kookana RS (2018) Sorption, plant uptake
and metabolism of benzodiazepines. Sci Total Environ 628:18–25
32. Bhalsod GD, Chuang Y-H, Jeon S, Gui W, Li H, Ryser ET, Guber AK, Zhang W (2018)
Uptake and accumulation of pharmaceuticals in overhead-and surface-irrigated greenhouse
lettuce. J Agric Food Chem 66(4):822–830
33. Albero B, Tadeo JL, Miguel E, Pérez RA (2019) Rapid determination of antibiotic residues in
cereals by liquid chromatography triple mass spectrometry. Anal Bioanal Chem 411
(23):6129–6139
34. Liu X, Liang C, Liu X, Zhao F, Han C (2020) Occurrence and human health risk assessment of
pharmaceuticals and personal care products in real agricultural systems with long-term
reclaimed wastewater irrigation in Beijing, China. Ecotoxicol Environ Saf 190:110022
35. Chen H, Marín-Sáez J, Romero-González R, Frenich AG (2017) Simultaneous determination
of atropine and scopolamine in buckwheat and related products using modified QuEChERS
and liquid chromatography tandem mass spectrometry. Food Chem 218:173–180
36. Malhat F, Almaz M, Arief M, El-Din K, Fathy M (2012) Residue and dissipation dynamics of
lufenuron in tomato fruit using QuEChERS methodology. Bull Environ Contam Toxicol 89
(5):1037–1039
37. Sun C, Dudley S, Trumble J, Gan J (2018) Pharmaceutical and personal care products-induced
stress symptoms and detoxification mechanisms in cucumber plants. Environ Pollut
234:39–47
38. Kommawar SS, Bakal RL, Dewani A, Chandewar AV (2020) Expension in the field of freezedrying: an advanced review. Res J Pharm Technol 13(5):2468–2474
39. Azanu D, Mortey C, Darko G, Weisser JJ, Styrishave B, Abaidoo RC (2016) Uptake of
antibiotics from irrigation water by plants. Chemosphere 157:107–114
40. Herklotz PA, Gurung P, Heuvel BV, Kinney CA (2010) Uptake of human pharmaceuticals by
plants grown under hydroponic conditions. Chemosphere 78(11):1416–1421
41. Kodešová R, Klement A, Golovko O, Fér M, Nikodem A, Kočárek M, Grabic R (2019) Root
uptake of atenolol, sulfamethoxazole and carbamazepine, and their transformation in three
soils and four plants. Environ Sci Pollut Res 26(10):9876–9891
Development of Methods for the Determination of PhACs in Soil/Earthworm/Crop. . .
481
pharmaceuticals in sediments by LC-Orbitrap HRMS. Anal Bioanal Chem 411(7):1383–1396
23. Pinto CG, Laespada MEF, Martín SH, Ferreira AMC, Pavón JLP, Cordero BM (2010)
Simplified QuEChERS approach for the extraction of chlorinated compounds from soil
samples. Talanta 81(1–2):385–391
24. Plössl F, Giera M, Bracher F (2006) Multiresidue analytical method using dispersive solidphase extraction and gas chromatography/ion trap mass spectrometry to determine pharmaceuticals in whole blood. J Chromatogr A 1135(1):19–26
25. Lehotay SJ, Tully J, Garca AV, Contreras M, Mol H, Heinke V, Anspach T, Lach G, Fussell R,
Mastovska K (2007) Determination of pesticide residues in foods by acetonitrile extraction
and partitioning with magnesium sulfate: collaborative study. J AOAC Int 90(2):485–520
26. CEN (2008) Foods of plant origin-Determination of pesticide residues using GC-MS and/or
LC-MS/MS following acetonitrile extraction/partitioning and clean-up by dispersive SPE.
QuEChERS-method EN 15662:2008
27. De Castro ML, Priego-Capote F (2010) Soxhlet extraction: past and present panacea. J
Chromatogr A 1217(16):2383–2389
28. Bartha B, Huber C, Harpaintner R, Schröder P (2010) Effects of acetaminophen in Brassica
juncea L. Czern.: investigation of uptake, translocation, detoxification, and the induced
defense pathways. Environ Sci Pollut Res 17(9):1553–1562
29. Pavlović DM, Babić S, Horvat AJ, Kaštelan-Macan M (2007) Sample preparation in analysis
of pharmaceuticals. TrAC Trends Anal Chem 26(11):1062–1075
30. Klein C, O’Connor S, Locke J, Aga D (2008) Sample preparation and analysis of solid-bound
pharmaceuticals. CRC Press, Boca Raton
31. Carter LJ, Williams M, Martin S, Kamaludeen SP, Kookana RS (2018) Sorption, plant uptake
and metabolism of benzodiazepines. Sci Total Environ 628:18–25
32. Bhalsod GD, Chuang Y-H, Jeon S, Gui W, Li H, Ryser ET, Guber AK, Zhang W (2018)
Uptake and accumulation of pharmaceuticals in overhead-and surface-irrigated greenhouse
lettuce. J Agric Food Chem 66(4):822–830
33. Albero B, Tadeo JL, Miguel E, Pérez RA (2019) Rapid determination of antibiotic residues in
cereals by liquid chromatography triple mass spectrometry. Anal Bioanal Chem 411
(23):6129–6139
34. Liu X, Liang C, Liu X, Zhao F, Han C (2020) Occurrence and human health risk assessment of
pharmaceuticals and personal care products in real agricultural systems with long-term
reclaimed wastewater irrigation in Beijing, China. Ecotoxicol Environ Saf 190:110022
35. Chen H, Marín-Sáez J, Romero-González R, Frenich AG (2017) Simultaneous determination
of atropine and scopolamine in buckwheat and related products using modified QuEChERS
and liquid chromatography tandem mass spectrometry. Food Chem 218:173–180
36. Malhat F, Almaz M, Arief M, El-Din K, Fathy M (2012) Residue and dissipation dynamics of
lufenuron in tomato fruit using QuEChERS methodology. Bull Environ Contam Toxicol 89
(5):1037–1039
37. Sun C, Dudley S, Trumble J, Gan J (2018) Pharmaceutical and personal care products-induced
stress symptoms and detoxification mechanisms in cucumber plants. Environ Pollut
234:39–47
38. Kommawar SS, Bakal RL, Dewani A, Chandewar AV (2020) Expension in the field of freezedrying: an advanced review. Res J Pharm Technol 13(5):2468–2474
39. Azanu D, Mortey C, Darko G, Weisser JJ, Styrishave B, Abaidoo RC (2016) Uptake of
antibiotics from irrigation water by plants. Chemosphere 157:107–114
40. Herklotz PA, Gurung P, Heuvel BV, Kinney CA (2010) Uptake of human pharmaceuticals by
plants grown under hydroponic conditions. Chemosphere 78(11):1416–1421
41. Kodešová R, Klement A, Golovko O, Fér M, Nikodem A, Kočárek M, Grabic R (2019) Root
uptake of atenolol, sulfamethoxazole and carbamazepine, and their transformation in three
soils and four plants. Environ Sci Pollut Res 26(10):9876–9891
Development of Methods for the Determination of PhACs in Soil/Earthworm/Crop. . .
481