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117. Nason SL, Miller EL, Karthikeyan KG, Pedersen JA (2019) Effects of binary mixtures and
transpiration on accumulation of pharmaceuticals by spinach. Environ Sci Technol
53:4850–4859. https://doi.org/10.1021/acs.est.8b05515
118. Sun C, Dudley S, McGinnis M, Trumble J, Gan J (2019) Acetaminophen detoxification in
cucumber plants via induction of glutathione S-transferases. Sci Total Environ 649:431–439.
https://doi.org/10.1016/j.scitotenv.2018.08.346
119. Zhang DQ, Gersberg RM, Hua T, Zhu J, Goyal MK, Ng WJ, Tan SK (2013) Fate of
pharmaceutical compounds in hydroponic mesocosms planted with Scirpus validus. Environ
Pollut 181:98–106. https://doi.org/10.1016/j.envpol.2013.06.016
120. Chuang YH, Liu CH, Hammerschmidt R, Zhang W, Boyd SA, Li H (2018) Metabolic
demethylation and oxidation of caffeine during uptake by lettuce. J Agric Food Chem
66:7907–7915. https://doi.org/10.1021/acs.jafc.8b02235
121. Fu Q, Wu X, Ye Q, Ernst F, Gan J (2016) Biosolids inhibit bioavailability and plant uptake of
triclosan and triclocarban. Water Res 102:117–124. https://doi.org/10.1016/j.watres.2016.06.
026
122. Al-Rimawi F, Hijaz F, Nehela Y, Batuman O, Killiny N (2019) Uptake, translocation, and
stability of oxytetracycline and streptomycin in citrus plants. Antibiotics 8:196. https://doi.org/
10.3390/antibiotics8040196
123. Klement A, Kodešová R, Golovko O, Fér M, Nikodem A, Kočárek M, Grabic R (2020)
Uptake, translocation and transformation of three pharmaceuticals in green pea plants. J
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124. Beltrán EM, Pablos MV, Fernández Torija C, Porcel MÁ, González-Doncel M (2020) Uptake
of atenolol, carbamazepine and triclosan by crops irrigated with reclaimed water in a Mediterranean scenario. Ecotoxicol Environ Saf 191:110171. https://doi.org/10.1016/j.ecoenv.
2020.110171
125. Carter LJ, Harris E, Williams M, Ryan JJ, Kookana RS, Boxall ABA (2014) Fate and uptake
of pharmaceuticals in soil-plant systems. J Agric Food Chem 62:816–825. https://doi.org/10.
1021/jf404282y
126. He Y, Sutton NB, Lei Y, Rijnaarts HHM, Langenhoff AAM (2018) Fate and distribution of
pharmaceutically active compounds in mesocosm constructed wetlands. J Hazard Mater
357:198–206. https://doi.org/10.1016/j.jhazmat.2018.05.035
127. Hurtado C, Cañameras N, Domínguez C, Price GW, Comas J, Bayona JM (2017) Effect of soil
biochar concentration on the mitigation of emerging organic contaminant uptake in lettuce. J
Hazard Mater 323:386–393. https://doi.org/10.1016/j.jhazmat.2016.04.046
128. Knight ER, Carter LJ, McLaughlin MJ (2018) Bioaccumulation, uptake, and toxicity of
carbamazepine in soil-plant systems. Environ Toxicol Chem 37:1122–1130. https://doi.org/
10.1002/etc.4053
129. Cantarero R, Richter P, Brown S, Ascar L, Ahumada I (2017) Effects of applying biosolids to
soils on the adsorption and bioavailability of 17α-ethinylestradiol and triclosan in wheat
plants. Environ Sci Pollut Res 24:12847–12859. https://doi.org/10.1007/s11356-017-8836-5
130. Carter LJ, Williams M, Martin S, Kamaludeen SPB, Kookana RS (2018) Sorption, plant
uptake and metabolism of benzodiazepines. Sci Total Environ 628–629:18–25. https://doi.org/
10.1016/j.scitotenv.2018.01.337
131. Santiago S, Roll DM, Ray C, Williams C, Moravcik P, Knopf A (2016) Effects of soil
moisture depletion on vegetable crop uptake of pharmaceuticals and personal care products
(PPCPs). Environ Sci Pollut Res 23:20257–20268. https://doi.org/10.1007/s11356-016-7194-z
132. Azanu D, Mortey C, Darko G, Weisser JJ, Styrishave B, Abaidoo RC (2016) Uptake of
antibiotics from irrigation water by plants. Chemosphere 157:107–114. https://doi.org/10.
1016/j.chemosphere.2016.05.035
133. Di Baccio D, Pietrini F, Bertolotto P, Pérez S, Barcelò D, Zacchini M, Donati E (2017)
Response of Lemna gibba L. to high and environmentally relevant concentrations of
Uptake and Translocation of Pharmaceuticals in Plants:. . .
139
https://doi.org/10.1016/j.jhazmat.2015.11.039
117. Nason SL, Miller EL, Karthikeyan KG, Pedersen JA (2019) Effects of binary mixtures and
transpiration on accumulation of pharmaceuticals by spinach. Environ Sci Technol
53:4850–4859. https://doi.org/10.1021/acs.est.8b05515
118. Sun C, Dudley S, McGinnis M, Trumble J, Gan J (2019) Acetaminophen detoxification in
cucumber plants via induction of glutathione S-transferases. Sci Total Environ 649:431–439.
https://doi.org/10.1016/j.scitotenv.2018.08.346
119. Zhang DQ, Gersberg RM, Hua T, Zhu J, Goyal MK, Ng WJ, Tan SK (2013) Fate of
pharmaceutical compounds in hydroponic mesocosms planted with Scirpus validus. Environ
Pollut 181:98–106. https://doi.org/10.1016/j.envpol.2013.06.016
120. Chuang YH, Liu CH, Hammerschmidt R, Zhang W, Boyd SA, Li H (2018) Metabolic
demethylation and oxidation of caffeine during uptake by lettuce. J Agric Food Chem
66:7907–7915. https://doi.org/10.1021/acs.jafc.8b02235
121. Fu Q, Wu X, Ye Q, Ernst F, Gan J (2016) Biosolids inhibit bioavailability and plant uptake of
triclosan and triclocarban. Water Res 102:117–124. https://doi.org/10.1016/j.watres.2016.06.
026
122. Al-Rimawi F, Hijaz F, Nehela Y, Batuman O, Killiny N (2019) Uptake, translocation, and
stability of oxytetracycline and streptomycin in citrus plants. Antibiotics 8:196. https://doi.org/
10.3390/antibiotics8040196
123. Klement A, Kodešová R, Golovko O, Fér M, Nikodem A, Kočárek M, Grabic R (2020)
Uptake, translocation and transformation of three pharmaceuticals in green pea plants. J
Hydrol Hydromech 68(1):1–11. https://doi.org/10.2478/johh-2020-0001
124. Beltrán EM, Pablos MV, Fernández Torija C, Porcel MÁ, González-Doncel M (2020) Uptake
of atenolol, carbamazepine and triclosan by crops irrigated with reclaimed water in a Mediterranean scenario. Ecotoxicol Environ Saf 191:110171. https://doi.org/10.1016/j.ecoenv.
2020.110171
125. Carter LJ, Harris E, Williams M, Ryan JJ, Kookana RS, Boxall ABA (2014) Fate and uptake
of pharmaceuticals in soil-plant systems. J Agric Food Chem 62:816–825. https://doi.org/10.
1021/jf404282y
126. He Y, Sutton NB, Lei Y, Rijnaarts HHM, Langenhoff AAM (2018) Fate and distribution of
pharmaceutically active compounds in mesocosm constructed wetlands. J Hazard Mater
357:198–206. https://doi.org/10.1016/j.jhazmat.2018.05.035
127. Hurtado C, Cañameras N, Domínguez C, Price GW, Comas J, Bayona JM (2017) Effect of soil
biochar concentration on the mitigation of emerging organic contaminant uptake in lettuce. J
Hazard Mater 323:386–393. https://doi.org/10.1016/j.jhazmat.2016.04.046
128. Knight ER, Carter LJ, McLaughlin MJ (2018) Bioaccumulation, uptake, and toxicity of
carbamazepine in soil-plant systems. Environ Toxicol Chem 37:1122–1130. https://doi.org/
10.1002/etc.4053
129. Cantarero R, Richter P, Brown S, Ascar L, Ahumada I (2017) Effects of applying biosolids to
soils on the adsorption and bioavailability of 17α-ethinylestradiol and triclosan in wheat
plants. Environ Sci Pollut Res 24:12847–12859. https://doi.org/10.1007/s11356-017-8836-5
130. Carter LJ, Williams M, Martin S, Kamaludeen SPB, Kookana RS (2018) Sorption, plant
uptake and metabolism of benzodiazepines. Sci Total Environ 628–629:18–25. https://doi.org/
10.1016/j.scitotenv.2018.01.337
131. Santiago S, Roll DM, Ray C, Williams C, Moravcik P, Knopf A (2016) Effects of soil
moisture depletion on vegetable crop uptake of pharmaceuticals and personal care products
(PPCPs). Environ Sci Pollut Res 23:20257–20268. https://doi.org/10.1007/s11356-016-7194-z
132. Azanu D, Mortey C, Darko G, Weisser JJ, Styrishave B, Abaidoo RC (2016) Uptake of
antibiotics from irrigation water by plants. Chemosphere 157:107–114. https://doi.org/10.
1016/j.chemosphere.2016.05.035
133. Di Baccio D, Pietrini F, Bertolotto P, Pérez S, Barcelò D, Zacchini M, Donati E (2017)
Response of Lemna gibba L. to high and environmentally relevant concentrations of
Uptake and Translocation of Pharmaceuticals in Plants:. . .
139